公开(公告)号：WO2005000808A1

公开(公告)日：2005-01-06

申请号：PCT/US2004/019442

申请日：2004-06-17

Applicant: INVISTA TECHNOLOGIES S.A R.L. ,  KIRBY, Gregory, S. ,  OSTERMAIER, John, J.

Inventor： KIRBY, Gregory, S. ,  OSTERMAIER, John, J.

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Method for making caprolactam from 6-aminocapronitrile that contains greater than 500 ppm tetrahydroazepine and its derivatives (THA) in which the THA is not removed from the method until after the caprolactam is produced.

Abstract translation: 从6-氨基己腈制备己内酰胺的方法，其含有大于500ppm的四氮氮平及其衍生物（THA），其中THA不从该方法中除去，直到己内酰胺生产。

公开(公告)号：WO02050025A1

公开(公告)日：2002-06-27

申请号：PCT/JP2001/001759

申请日：2001-03-07

IPC: C07D205/08 ,  C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/582

Abstract: A process for synthesizing a beta -lactam in water at a high temperature under a high pressure; and a process for producing a beta -lactam. Namely, a process for synthesizing a ss-lactam characterized by reacting a beta -amino acid in water at a high temperature under a high pressure, wherein the beta -lactam is synthesized at a high rate by cyclizing the beta -amino acid in water at a high temperature of 200 DEG C or more under a high pressure of 10 Mpa or more; and a process for producing a beta -lactam characterized by synthesizing the beta -lactam by reacting a beta -amino acid in water at a high temperature under a high pressure and then separating and purifying the beta -lactam with the use of a column separating agent.

Abstract translation: 一种在高温高压下在水中合成β-内酰胺的方法; 和β-内酰胺的制备方法。 即，合成β-内酰胺的方法，其特征在于在高温下在高压下使β-氨基酸在水中反应，其中通过使水中的β-氨基酸环化，以高速率合成β-内酰胺 在10MPa以上的高压下高温200℃以上; 和β-内酰胺的制备方法，其特征在于通过在高温高压下使β-氨基酸在水中反应而合成β-内酰胺，然后使用柱分离剂分离和纯化β-内酰胺 。

公开(公告)号：WO01090065A1

公开(公告)日：2001-11-29

申请号：PCT/FR2001/001644

申请日：2001-05-28

IPC: C07D223/12 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/16 ,  C07D201/08 ,  Y10S203/90

Abstract: The invention concerns a method for purifying lactams, more particularly lactams obtained by cyclizing hydrolysis of aminonitrile. More particularly, the invention concerns the purification of epsilon -caprolactam obtained by cyclizing hydrolysis of aminocapronitrile which consists in eliminating the ammonia from the reaction medium of the hydrolysis then in recuperating the lactam from said medium in purified form. Said recuperation is carried out by performing at least a distillation of the lactam in the presence of a base producing optionally a fronts fraction comprising compounds more volatile than the lactam, a fraction comprising the lactam to be recuperated to the degree of desired purity and a distillation tails comprising the lactam and compounds less volatile than the lactam. The distillation tails are treated by various processes such as evaporation in thin layers to recuperate the major part of the comprised caprolactam and recycling the latter in the purification process. The invention enables a high rate of recuperation of the caprolactam contained in the hydrolysis medium, while observing the required criteria of purity.

Abstract translation: 本发明涉及一种纯化内酰胺的方法，更特别的是通过环化氨基腈的水解得到的内酰胺。 更具体地说，本发明涉及通过环化氨基己腈的水解而获得的ε-己内酰胺的纯化，其包括从水解反应介质中除去氨，然后在纯化形式从所述介质中回收内酰胺。 所述再生是通过在碱的存在下至少进行内酰胺的蒸馏来进行的，所述碱可任选地产生包含比内酰胺更易挥发的化合物的前列馏分，所述馏分包含待回收到所需纯度的内酰胺和蒸馏 尾部包含内酰胺和化合物比内酰胺更不易挥发。 蒸馏尾部通过各种方法处理，例如在薄层中蒸发以回收主要部分的己内酰胺并在净化过程中再循环。 本发明能够在观察所需的纯度标准的同时高效地回收水解介质中所含的己内酰胺。

公开(公告)号：WO01083442A1

公开(公告)日：2001-11-08

申请号：PCT/EP2001/004834

申请日：2001-04-30

IPC: C07D223/10 ,  C07B61/00 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: The invention relates to a method for producing caprolactam, characterized in that a) a mixture (I) containing 6-aminocapronitrile and water in the liquid phase is converted into a mixture (II) containing caprolactam, ammonia, water, high boilers and low boilers in the presence of a catalyst; b) ammonia is then removed from mixture (II), leaving a mixture (III) containing caprolactam, water, high boilers and low boilers; c) water is then removed from mixture (III) leaving a mixture (IV) containing caprolactam, high boilers and low boilers, and d) a solid (V) containing caprolactam is obtained from mixture (IV) by crystallization, the proportion by weight of caprolactam in the solid (V) being greater than that in the mixture (IV).

Abstract translation: 一种用于含有己内酰胺，氨，水，高沸点和低沸点在催化剂的存在下，然后将包含在液相中6-氨基己腈与水（以共混物II）制备己内酰胺，其特征在于，a）的混合物（I）的过程 b）从所述混合物（II）的氨除去，得到含有己内酰胺，高沸点和低沸点的混合物（III），其包括从（III）的水被除去，混合物己内酰胺，水，高沸点和低沸点，然后c）（以得到的混合物IV），和 然后d）为从混合物（IV）由结晶化的含有己内酰胺的固体（V），其特征在于，按重量计在固体（V己内酰胺的比例）比在混合物（IV）大。

公开(公告)号：WO01030755A1

公开(公告)日：2001-05-03

申请号：PCT/EP2000/010509

申请日：2000-10-25

IPC: C07D207/26 ,  C07D207/267 ,  C07D201/08

CPC classification number: C07D207/267

Abstract: A process for the production of N-methyl pyrrolidone using gamma butyrolactone and mixed methylamines as starting materials, in a continuous process, in such operating conditions as to allow the production of high purity N-methyl pyrrolidone in high yields.

Abstract translation: 在这样的操作条件下，以高产率生产高纯度N-甲基吡咯烷酮的方法，在连续方法中使用γ-丁内酯和混合甲胺作为起始原料生产N-甲基吡咯烷酮的方法。

公开(公告)号：WO0014062A8

公开(公告)日：2000-06-08

申请号：PCT/NL9900544

申请日：1999-09-01

Applicant: DSM NV ,  DU PONT ,  PESTMAN ROBERT ,  LIESHOUT LAMBERTUS HUBERTUS WI

Inventor： PESTMAN ROBERT ,  VAN LIESHOUT LAMBERTUS HUBERTU

IPC: C07D223/10 ,  B01J23/46 ,  C07B61/00 ,  C07C227/08 ,  C07C229/08 ,  C07C231/14 ,  C07C237/06 ,  C07D201/08

CPC classification number: C07C227/08 ,  C07C231/14 ,  C07D201/08 ,  Y02P20/52

Abstract: Process for preparing an aqueous mixture of epsilon -caprolactam and 6-aminocaproic acid and or 6-aminocaproamide which involves, as the reductive amination step, contacting 5-formylvaleric acid and/or an alkyl 5-formylvalerate in water as solvent with hydrogen and an excess of ammonia in the presence of a ruthenium on carrier, as a catalyst, wherein the carrier is titanium oxide, zirconium oxide, graphite or carbon and the catalyst also contains at least one of the metals of group 8-11, or a compound of these metals. The aqueous mixture can be used to prepare epsilon -caprolactam.

Abstract translation: 制备ε-己内酰胺和6-氨基己酸和/或6-氨基己酰胺的含水混合物的方法，其涉及作为还原胺化步骤的5-甲酰基戊酸和/或5-甲酰戊酸烷基酯作为溶剂与氢气和 在作为催化剂的载体上存在钌时过量的氨，其中载体是氧化钛，氧化锆，石墨或碳，并且催化剂还含有至少一种第8-11族金属，或者 这些金属。 含水混合物可用于制备ε-己内酰胺。

公开(公告)号：WO00031031A1

公开(公告)日：2000-06-02

申请号：PCT/FR1999/002823

申请日：1999-11-18

IPC: C07D223/10 ,  B01J38/00 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: The invention concerns a method for treating lactams. Said method enables in particular to modify the chemical nature of impurities contained in a medium containing lactams either for transforming them into non-troublesome compounds or extractable compounds in subsequent purifying operations. It consists in hydrogenating in the presence of ammonia the medium containing the lactam.

Abstract translation: 本发明涉及一种处理内酰胺的方法。 所述方法特别能够改变包含在含有内酰胺的培养基中的杂质的化学性质，以便在随后的纯化操作中将其转化成非麻烦的化合物或可萃取的化合物。 它包括在氨存在下氢化含有内酰胺的培养基。

公开(公告)号：WO00006540A1

公开(公告)日：2000-02-10

申请号：PCT/FR1999/001732

申请日：1999-07-15

IPC: C07D223/10 ,  B01D3/10 ,  B01D3/14 ,  B01D3/16 ,  B01D3/42 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/16 ,  Y10S203/16

Abstract: The invention concerns a method for separating water from an aqueous lactam solution, more particularly applicable to a mixture derived from the reaction between an aminonitrile and water (reaction which is also called cyclizing hydrolysis). It concerns a method for separating water from an aqueous lactam solution, method which is economical both in terms of the necessary investment for its implementation and in terms of operational costs.

Abstract translation: 本发明涉及从内酰胺水溶液中分离水的方法，更特别适用于衍生自氨基腈和水之间的反应的混合物（反应也称为环化水解）。 它涉及从含水内酰胺溶液中分离水的方法，在实施必要投资和运营成本方面都是经济的。

公开(公告)号：WO9809947A3

公开(公告)日：2000-01-20

申请号：PCT/US9714223

申请日：1997-08-13

Applicant: DU PONT

Inventor： HERKES FRANK EDWARD

IPC: C07D211/02 ,  C07D211/76 ,  C07D201/08

CPC classification number: C07D211/76

Abstract: This invention relates to an improved process for the preparation of 1-alkyl-3-methylpiperidone-2 and 1-alkyl-5-methylpiperidone-2 from 2-methylglutaronitrile wherein the selectivity of the process to bis-1,5-(methylamido)-3-methylpentane is less than 8%.

Abstract translation: 本发明涉及从2-甲基戊二腈制备1-烷基-3-甲基哌啶酮-2和1-烷基-5-甲基哌啶酮-22的改进方法，其中该方法对双-1,5-（甲基酰氨基） -3-甲基戊烷小于8％。

公开(公告)号：WO99011613A1

公开(公告)日：1999-03-11

申请号：PCT/EP1998/005333

申请日：1998-08-21

IPC: B01J21/06 ,  B01J37/06 ,  C07D201/08

CPC classification number: B01J37/06 ,  C07D201/08 ,  Y02P20/52

Abstract: The invention relates to the use of essentially shaped bodies containing a catalytically active oxide as a catalyst comprising no soluble constituent, under the reaction conditions, for the production of cyclic lactams by reacting aminocarboxylic acid nitriles with water in aqueous phase, in a fixed bed reactor. This catalyst is composed of shaped bodies which can be obtained by shaping the oxide into shaped bodies and by treating the oxide with an acid which is hardly soluble, having 0.1 to 30 % by weight of the oxide, before or after the shaping process.

Abstract translation: 使用基本上包含催化活性氧化物成型体催化剂，其特征在于，在反应条件下，没有水溶性成分，在固定床反应器中，其特征在于，该催化剂由通过与水的氨基腈以成型体，其通过可获得的液相反应来制备环状内酰胺 前或在基于其中的氧化物是微溶的酸的氧化物为0.1〜30重量％成型后成型氧化物成成型制品和治疗氧化物。