公开(公告)号：WO2016044492A1

公开(公告)日：2016-03-24

申请号：PCT/US2015/050531

申请日：2015-09-16

Applicant: CARBO CERAMICS INC. ,  SANDIA CORPORATION ,  STC.UNM

Inventor： CANNAN, Chad ,  PALISCH, Terrence ,  KEMP, Richard, A. ,  BOYLE, Timothy, J. ,  HERNANDEZ-SANCHEZ, Bernadette, A. ,  MILLER, James, E.

IPC: C09K8/80 ,  E21B43/267 ,  E21B47/11

CPC classification number: C09K8/80 ,  C09K8/805 ,  E21B43/267 ,  E21B47/1015

Abstract: Proppant compositions for use in hydraulic fracturing and methods of using same are disclosed herein. The proppant compositions include a plurality of proppant particulates and at least one particulate of the plurality of proppant particulates containing at least one tracer, wherein the at least one tracer separates from the at least one particulate located inside a fracture of a subterranean formation after a period of time.

Abstract translation: 用于水力压裂的支撑剂组合物及其使用方法在本文中公开。 支撑剂组合物包括多个支撑剂颗粒和至少一个含有至少一个示踪剂的支撑剂颗粒的至少一个颗粒，其中至少一个示踪剂在一段时间后与位于地下岩层内部的至少一个颗粒分离 的时间。

公开(公告)号：WO2015142867A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/020991

申请日：2015-03-17

Applicant: STC.UNM ,  IDE, Hiroshi

Inventor： IDE, Hiroshi ,  MATSUMOTO, Yoshihiro ,  TOMKINSON, Alan, Edward

IPC: A61K31/506 ,  A61K31/513 ,  A61K31/7072 ,  A61P35/00

CPC classification number: A61K31/7072 ,  A61K31/337 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/513 ,  A61K31/519 ,  A61K31/55 ,  A61K31/555 ,  A61K31/675 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/14 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2'-deoxyuridine (fdU or foUdR) or a 5-formyl-2'-deoxyuridine derivative, optionally in combination with 5-hydroxy-2'-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5- fluoro-2'-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2'- deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

Abstract translation: 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的（a）5-甲酰基-2'-头孢菌素，治疗患有肿瘤（包括癌症，例如放射治疗耐药性癌症）的受试者的方法， 脱氧尿苷（fdU或foUdR）或5-甲酰基-2'-脱氧尿苷衍生物，任选与5-羟基-2'-脱氧尿苷（hUdR）组合; 和（b）至少一种选自5-氟尿嘧啶（5-FU），5-FU前药（例如5-氟-2'-脱氧尿苷（FdU））或5-FU代谢物的组合物。 在优选的实施方案中，患有结肠直肠癌（CRC）或转移性结肠直肠癌（mCRC）的受试者用治疗有效量的fdU和5-FU或5-FU前药5-氟-2'- 脱氧尿苷（FdU）。 还提供了相关的药物组合物。

公开(公告)号：WO2015123291A1

公开(公告)日：2015-08-20

申请号：PCT/US2015/015408

申请日：2015-02-11

Applicant: THE USA, as represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES ,  STC.UNM

Inventor： REMALEY, Alan ,  SCHILLERR, John, T. ,  AMAR, Marcelo ,  CHACKERIAN, Bryce

IPC: A61K39/00 ,  C12N9/64 ,  A61P3/06 ,  A61P9/00

CPC classification number: A61K39/0005 ,  A61K38/10 ,  A61K45/06 ,  A61K47/6901 ,  A61K2039/60 ,  A61K2039/627 ,  A61P9/10 ,  C07K11/00 ,  C07K14/47 ,  C12N9/6454 ,  C12N2795/18123 ,  C12N2795/18134 ,  C12N2795/18141 ,  C12Y304/21061

Abstract: A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.

Abstract translation: 包含抗原性PCSK9肽和免疫原性载体的疫苗构建体及其使用方法，其有效降低哺乳动物的血液胆固醇水平并且治疗哺乳动物的血脂异常和相关疾病状态，而不需要被动免疫策略所需的施用频率 。

公开(公告)号：WO2015085143A2

公开(公告)日：2015-06-11

申请号：PCT/US2014/068739

申请日：2014-12-05

Applicant: STC.UNM

Inventor： VANDER JAGT, David L. ,  DECK, Lorraine M. ,  ROYER, Robert E. ,  HEIDRICH, John E.

IPC: A61K31/136

CPC classification number: A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans - stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans -stilbene or stilbene hybrid and at least one antibiotic.

Abstract translation: 本发明涉及治疗罹患皮肤疾病或病症的受试者的方法，所述方法包括向需要的受试者或患者施用包含治疗有效量的取代的 顺式或反式二苯乙烯或二苯乙烯杂化物。 治疗或减少患者皮肤疾病或病症可能性的方法是本发明的另一个实施方案。 本发明优选的药物组合物包括纳米乳剂，其包含治疗有效量的取代的顺式或反式 - 二苯乙烯或二苯乙烯杂化物和至少一种抗生素。

公开(公告)号：WO2015054044A2

公开(公告)日：2015-04-16

申请号：PCT/US2014/058949

申请日：2014-10-03

Applicant: STC.UNM

Inventor： LESEMAN, Zayd ,  ABBAS, Khawar ,  ELAHI, Mirza ,  KHEYRADDINI MOUSAVI, Arash ,  LIMA, Edidson ,  MOYA, Stephen

CPC classification number: B23K10/006 ,  B23K10/003 ,  G01F17/00 ,  G01F22/02 ,  G04F13/06

Abstract: Provided is a method for determining a volume, at room temperature, of a first chamber having an unknown volume that is in fluid communication through a controllable valve with a second chamber having an unknown volume. The method can include measuring, by a pressure sensor coupled to one of the first chamber and the second chamber, a first equilibrium pressure of a gas that was introduced into the second chamber in both the first chamber and the second chamber after equilibrium is reached; measuring, by the pressure sensor, a second equilibrium pressure of the gas that was introduced into the second chamber in both the first chamber and the second chamber after equilibrium is reached, wherein the first chamber comprises an object with a known volume therein; and determining the volume of the first chamber based on the first equilibrium pressure and the second equilibrium pressure.

Abstract translation: 提供了一种用于确定在室温下具有未知体积的第一室的体积的方法，第一室通过具有未知体积的第二室的可控阀流体连通。 该方法可以包括通过耦合到第一室和第二室中的一个的压力传感器测量在达到平衡之后被引入第二室和第二室中的第二室中的气体的第一平衡压力; 通过所述压力传感器测量在达到平衡之后被引入所述第一室和所述第二室中的第二室中的气体的第二平衡压力，其中所述第一室包括其中具有已知体积的物体; 以及基于所述第一平衡压力和所述第二平衡压力来确定所述第一室的体积。

公开(公告)号：WO2015023830A1

公开(公告)日：2015-02-19

申请号：PCT/US2014/051025

申请日：2014-08-14

Applicant: STC.UNM

Inventor： HILL, Jeff, Wade

IPC: A61K31/135 ,  A61K31/045 ,  A61K31/085

CPC classification number: A61K31/138 ,  A61K9/0019 ,  A61K31/27 ,  A61K31/325 ,  A61K45/06 ,  G01N33/5058 ,  A61K2300/00

Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

Abstract translation: 使用高通量筛选，在氧 - 葡萄糖剥夺（OGD）模型中，将isoxsuprine盐酸盐鉴定为有效的神经保护性化合物。 在短暂性局灶性缺血的动物中动脉闭塞（MCAO）模型中，与载体相比，isoxsuprine显着降低了梗死体积。 因此，本发明提供了治疗和药物组合物的方法，其可用于治疗和预防各种与缺血相关的损伤，包括中风。

公开(公告)号：WO2015002925A1

公开(公告)日：2015-01-08

申请号：PCT/US2014/045007

申请日：2014-07-01

Applicant: STC.UNM ,  SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  ANDERSEN, Nalin

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  ANDERSEN, Nalin

IPC: C01B31/04 ,  B01J35/10

CPC classification number: C01B31/0446 ,  B01J21/18 ,  B01J23/40 ,  B01J23/56 ,  B01J23/8926 ,  B01J35/0013 ,  B01J37/084 ,  C01B32/184 ,  C01B2204/02 ,  C01B2204/04 ,  H01M4/362 ,  H01M10/0525

Abstract: Novel non-planar non-contigous graphene structures and novel methods for forming the same. According to some embodiments the novel methods result in three-dimensional graphene structures. According to a further embodiment these three-dimensional graphene structures have a specific, controlled morphology. According to a still further method the novel method results in decoratable graphene sheets or three-dimensional graphene structures.

Abstract translation: 新型非平面非ous石墨烯结构及其形成方法。 根据一些实施方案，新方法产生三维石墨烯结构。 根据另一个实施方案，这些三维石墨烯结构具有特定的受控形态。 根据另一种方法，新方法产生可装饰的石墨烯片或三维石墨烯结构。

公开(公告)号：WO2014110498A1

公开(公告)日：2014-07-17

申请号：PCT/US2014/011277

申请日：2014-01-13

Applicant: STC.UNM ,  BABANOVA, Sofiya, Malinova ,  ATANASSOV, Plamen, B.

Inventor： BABANOVA, Sofiya, Malinova ,  ATANASSOV, Plamen, B.

IPC: H01M8/16

CPC classification number: H01M8/16 ,  H01M4/90 ,  H01M4/9008 ,  Y02E60/527

Abstract: A biofuel cell comprising an anode and cathode wherein biocatalytic enzymes are purposefully oriented at each side of the fuel cell so as to increase and/or optimize the enzymes' performance in catalysis and/or electron transfer.

Abstract translation: 一种包含阳极和阴极的生物燃料电池，其中生物催化酶有目的地定向在燃料电池的每一侧，以便增加和/或优化酶在催化和/或电子转移中的性能。

公开(公告)号：WO2014062639A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/064980

申请日：2013-10-15

Applicant: STC.UNM ,  SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  HALEVI, Barr ,  SHORT, Paul

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  HALEVI, Barr ,  SHORT, Paul

IPC: B01J37/08 ,  B01J23/745

CPC classification number: H01M4/9091 ,  B01J31/1805 ,  H01M4/8652 ,  H01M4/8814 ,  H01M4/8846 ,  H01M4/8885 ,  H01M4/9008 ,  H01M8/1011 ,  H01M2008/1095 ,  Y02E60/50 ,  Y02E60/523

Abstract: Novel catalytic materials and novel methods of preparing M-N-C catalytic materials utilizing a sacrificial support approach and using inexpensive active polymers as the carbon and nitrogen source and readily available metal precursors are described.

Abstract translation: 描述了新的催化材料和利用牺牲支撑方法制备M-N-C催化材料并使用廉价的活性聚合物作为碳源和氮源以及容易获得的金属前体的新方法。

公开(公告)号：WO2014058835A1

公开(公告)日：2014-04-17

申请号：PCT/US2013/063810

申请日：2013-10-08

Applicant: STC.UNM

Inventor： PANAIOTIS, .

IPC: G06F3/16 ,  G06F3/048

CPC classification number: G06F3/167 ,  G06F3/011 ,  G06F3/017 ,  G06F8/38

Abstract: The invention is directed to a system and methods allowing a user to interact with one or more data applications - including for example, games, music, music composition and tactile stimulation - to simulate real-time multisensory output. The invention includes a music program, a music texture program and a simulation program.

Abstract translation: 本发明涉及允许用户与一个或多个数据应用（包括例如游戏，音乐，音乐作品和触觉刺激）交互以便模拟实时多感觉输出的系统和方法。 本发明包括音乐节目，音乐纹理节目和模拟节目。