公开(公告)号：WO2013169393A1

公开(公告)日：2013-11-14

申请号：PCT/US2013/032519

申请日：2013-03-15

Applicant: STC.UNM

Inventor： HAN, Sang, M. ,  IVORY, Cornellius, F. ,  HOSSEIN-ZADEH, Mani

IPC: G01N33/53 ,  G01N35/08 ,  G01N21/75

CPC classification number: G01N33/5302 ,  B01L3/502753 ,  G01N21/75 ,  G01N21/7746 ,  G01N33/54373 ,  G01N33/5438 ,  G01N2021/755

Abstract: Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels. At least one analysis optical resonator is disposed in the analysis chamber and is optically coupled to at least a portion of the waveguide. The at least one analysis optical resonator is in fluid communication with at Ieast one of the plurality of nanochannels. At least one reference optical resonator is disposed in the reference chamber and is optically coupled to at least a portion of the waveguide. The at least one reference optical resonator is in fluid communication with at least one other of the plurality of nanochannels.

Abstract translation: 提供了一种传感器平台，其包括基板，设置在基板上的多个纳米通道，以及多个电极，设置在基板上的波导管和设置在基板上的分析室和基准室。 每个电极基本上跨越多个纳米通道的宽度延伸。 至少一个分析光学谐振器设置在分析室中并且光耦合到波导的至少一部分。 所述至少一个分析光学谐振器与所述多个纳米通道中的一个流体连通。 至少一个参考光学谐振器设置在参考室中并且光耦合到波导的至少一部分。 所述至少一个参考光学谐振器与所述多个纳米通道中的至少另一个流体连通。

公开(公告)号：WO2013165620A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/032613

申请日：2013-03-15

Applicant: STC.UNM

Inventor： BRUECK, Steven, R., J. ,  LEE, Seung-Chang ,  WETZEL, Christian ,  DETCHPROHM, Theeradetch ,  STARK, Christoph

IPC: H01L21/20 ,  H01L33/12

CPC classification number: H01L29/2003 ,  H01L21/02381 ,  H01L21/02395 ,  H01L21/0243 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/02494 ,  H01L21/02502 ,  H01L21/0251 ,  H01L21/0254 ,  H01L21/02546 ,  H01L21/02549 ,  H01L21/02587 ,  H01L21/02598 ,  H01L21/02658 ,  H01L29/15 ,  H01L33/16 ,  H01L33/24

Abstract: A semiconductor device is disclosed. The semiconductor device includes a substrate comprising a groove. A buffer layer is formed on a surface of the groove. The buffer layer comprising at least one material chosen from AIN, GaN or Al x Ga 1-x N, where x is between zero and one. An epitaxially grown semiconductor material is disposed over the buffer layer, at least a portion of the epitaxially grown semiconductor material having a cubic crystalline phase structure. Methods of forming the semiconductor devices are also taught.

Abstract translation: 公开了一种半导体器件。 半导体器件包括包括沟槽的衬底。 在槽的表面上形成缓冲层。 所述缓冲层包含至少一种选自AIN，GaN或Al x Ga 1-x N的材料，其中x在0和1之间。 外延生长的半导体材料设置在缓冲层之上，至少部分外延生长的半导体材料具有立方晶相结构。 还教导了形成半导体器件的方法。

公开(公告)号：WO2013138775A1

公开(公告)日：2013-09-19

申请号：PCT/US2013/032482

申请日：2013-03-15

Applicant: STC.UNM

Inventor： TAWK, Youssef, A. ,  CHRISTODOULOU, Christos, G. ,  COSTANTINE, Joseph

IPC: H01Q1/24 ,  H01Q15/24 ,  H01Q13/10

CPC classification number: H01Q1/50 ,  H01Q1/24 ,  H01Q13/085 ,  H01Q15/24

Abstract: Embodiments relate to systems and methods for a frequency reconfigurable filtenna system. Implementations incorporate a reconfigurable band-pass filter within the feeding line of an antenna structure. The combination of the filter and the antenna may be referred to as a "filtenna". Implementations integrate both the band-pass filter and the antenna within the same substrate, permitting easier, more efficient and more compact integration in the transceiver hardware. Moreover, by using this configuration, the biasing of the switching elements are not present in the radiating plane of the antenna. This reduces the negative effect of the biasing lines on the antenna radiation performance, as we!! as provides a tunable filtered antenna radiation characteristic.

Abstract translation: 实施例涉及用于频率可重构的文件系统的系统和方法。 实现在天线结构的馈电线内并入可重构带通滤波器。 滤波器和天线的组合可以被称为“滤波器”。 实现将带通滤波器和天线集成在相同的基板内，允许在收发器硬件中更容易，更有效和更紧凑的集成。 此外，通过使用这种结构，开关元件的偏置不存在于天线的辐射平面中。 这减少了偏置线对天线辐射性能的负面影响，因为我们！ 提供可调滤波天线辐射特性。

公开(公告)号：WO2013063366A2

公开(公告)日：2013-05-02

申请号：PCT/US2012/062073

申请日：2012-10-26

Applicant: STC.UNM

Inventor： HJELLE, Brian L. ,  PEABODY, David S. ,  CHACKERIAN, Bryce

IPC: G01N33/68 ,  G01N33/569 ,  C12Q1/68

CPC classification number: G01N33/6878 ,  G01N33/56983 ,  G01N33/6845 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/58 ,  Y02A50/60

Abstract: The invention is directed to methods of screening immunogenic viral like particles and related immunogenic compositions and diagnostic techniques. In one embodiment, the invention provides methods of screening immunogenic viral like particles containing peptides corresponding to epitope regions of a wide variety of pathogens, including viruses, bacteria, parasites, and microbes. Non-infectious antigens and allergens of interest can also be screened as described herein. Immunization, therapeutic and diagnostic applications are also described for the compositions and methods according to the invention. In another embodiment, the invention provides novel methods of identifying a cryptic neutralizing epitope and related vaccines, constructs, and libraries. In some embodiments, these methods use high-throughput formats that are facilitated by in silica or in vitro steps.

Abstract translation: 本发明涉及筛选免疫原性病毒样颗粒和相关免疫原性组合物和诊断技术的方法。 在一个实施方案中，本发明提供筛选含有对应于各种病原体（包括病毒，细菌，寄生虫和微生物）的表位区域的肽的免疫原性病毒样颗粒的方法。 如本文所述也可以筛选感兴趣的非感染性抗原和过敏原。 还描述了根据本发明的组合物和方法的免疫，治疗和诊断应用。 在另一个实施方案中，本发明提供了鉴定隐蔽中和表位和相关疫苗，构建体和文库的新方法。 在一些实施方案中，这些方法使用通过二氧化硅或体外步骤促进的高通量形式。

公开(公告)号：WO2013040567A3

公开(公告)日：2013-03-21

申请号：PCT/US2012/055774

申请日：2012-09-17

Applicant: STC.UNM ,  PATTERSON, Wendy ,  ROBSON, Michael ,  WALKER, Candace ,  SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B.

Inventor： PATTERSON, Wendy ,  ROBSON, Michael ,  WALKER, Candace ,  SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B.

IPC: B01J31/12 ,  B01J21/08

Abstract: Methods for forming novel fuel cell catalysts are described. The catalyst has a physical structure that is the inverse image of a plurality of hierarchically structured sacrificial support particles. The particles may be formed independently and then infused with one or more transitional metallic salts and nitrogen carbon precursors, or the sacrificial support precursors, transitional metallic salts, and nitrogen carbon precursors may all be combined in such a way that a hierarchically structured sacrificial support with the infused transitional metallic salts and nitrogen carbon precursors is formed in a single step. The infused sacrificial support is then pyrolized, at least once, and the sacrificial support is removed, resulting in the catalyst.

公开(公告)号：WO2012148953A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/034882

申请日：2012-04-25

Applicant: STC.UNM ,  SMYTH, Hugh ,  EL-SHERBINY, Ibrahim M.

Inventor： SMYTH, Hugh ,  EL-SHERBINY, Ibrahim M.

IPC: A61K9/14 ,  A61M31/00

CPC classification number: A61K47/48923 ,  A61K9/0075 ,  A61K9/5161 ,  A61K31/496

Abstract: The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.

Abstract translation: 本发明涉及可适用于向受试者施用治疗剂的固体组合物。 本发明还涉及制备这种固体组合物的方法。 本发明还涉及通过向受试者施用这种固体组合物来治疗疾病，病症或病症的方法。

公开(公告)号：WO2012079085A2

公开(公告)日：2012-06-14

申请号：PCT/US2011/064460

申请日：2011-12-12

Applicant: STC.UNM ,  WHITTEN, David ,  SCHANZE, Kirk ,  JI, Eunkyung ,  CORBITT, Thomas ,  DASCIER, Dimitri

Inventor： WHITTEN, David ,  SCHANZE, Kirk ,  JI, Eunkyung ,  CORBITT, Thomas ,  DASCIER, Dimitri

IPC: C08F238/00 ,  C08F220/00 ,  C08F220/56 ,  C12N15/87 ,  A01N31/08

CPC classification number: A01N41/04 ,  A01N33/12 ,  C08F230/08 ,  A01N25/10 ,  A01N37/38

Abstract: The present disclosure provides novel polyampholyte compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various polyampholytes show antibacterial activity and may also demonstrate antiviral antifungal and/or antibiofilm activity.

Abstract translation: 本公开提供了新的聚两性电解质化合物，合成这些化合物的方法以及掺入这些化合物的材料和物质。 各种聚两性电解质显示出抗菌活性，并且还可以显示出抗病毒抗真菌和/或抗菌膜活性。

公开(公告)号：WO2012037397A3

公开(公告)日：2012-03-22

申请号：PCT/US2011/051827

申请日：2011-09-15

Applicant: STC.UNM ,  PAUL, Surojit

Inventor： PAUL, Surojit

IPC: C07K14/47 ,  C07K19/00 ,  A61K38/17 ,  A61P25/00

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

公开(公告)号：WO2012009484A3

公开(公告)日：2012-01-19

申请号：PCT/US2011/043922

申请日：2011-07-13

Applicant: STC.UNM ,  WHITTEN, David ,  SCHANZE, Kirk ,  PARTHSARAY, Anand ,  JI, Eunkyung ,  OGAWA, Motokatsu ,  CORBITT, Thomas ,  DASCIER, Dimitri ,  WANG, Ying ,  ISTA, Linnea

Inventor： WHITTEN, David ,  SCHANZE, Kirk ,  PARTHSARAY, Anand ,  JI, Eunkyung ,  OGAWA, Motokatsu ,  CORBITT, Thomas ,  DASCIER, Dimitri ,  WANG, Ying ,  ISTA, Linnea

IPC: C08G61/02 ,  C08L65/00 ,  C08J5/00

Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

公开(公告)号：WO2012009472A2

公开(公告)日：2012-01-19

申请号：PCT/US2011/043908

申请日：2011-07-13

Applicant: STC.UNM ,  WHITTEN, David ,  SCHANZE, Kirk ,  JI, Eunkyung ,  CORBITT, Thomas ,  ZHOU, Zhijun ,  DASCIER, Dimitri ,  WANG, Ying ,  ISTA, Linnea ,  PARTHSARAY, Anand

Inventor： WHITTEN, David ,  SCHANZE, Kirk ,  JI, Eunkyung ,  CORBITT, Thomas ,  ZHOU, Zhijun ,  DASCIER, Dimitri ,  WANG, Ying ,  ISTA, Linnea ,  PARTHSARAY, Anand

IPC: C07D471/08 ,  C07C217/14 ,  C07D333/10 ,  A61K31/551 ,  A61P31/04

CPC classification number: C07D487/08 ,  C07C217/14 ,  C07C217/20 ,  C07C309/11 ,  C07C309/24 ,  C07D333/16 ,  C08G61/02 ,  C08G61/126 ,  C08G75/00 ,  C08G2261/312 ,  C08G2261/3223 ,  C08G2261/3328 ,  C08G2261/3422 ,  C08G2261/93

Abstract: The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

Abstract translation: 本公开提供了新的低聚亚苯基亚乙炔（OPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种OPE显示抗菌，抗病毒和抗真菌活性。