公开(公告)号：WO01083441A1

公开(公告)日：2001-11-08

申请号：PCT/EP2001/004833

申请日：2001-04-30

IPC: C07D223/10 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: The invention relates to a method for producing cyclic lactams of formula (II) by reacting a compound (I) of formula (I) with water in the presence of an organic, liquid dilution agent in the liquid phase. In formula (II), n and m respectively can have the values 0, 1, 2, 3, 4, 5, 6, 7, 8 and 9 and the sum of n + m is at least 3, preferably at least 4 and R and R represent C1-C6 alkyl, C5-C7 cycloalkyl or C6-C12 aryl groups. In formula (I), R , R , m and n are defined as above and R represents nitrile, carboxylic acid amide and carboxylic acid groups. The inventive method is characterized in that a) compound (I) is reacted with water in the liquid phase in the presence of an organic, liquid dilution agent (III) to form a mixture (IV) containing a lactam (II) and said mixture (IV) is subjected to an aqueous treatment to obtain a two-phase system.

Abstract translation: 一种用于制备式（II），其中n和m的环状内酰胺过程各自为0，1，2，3，4，5，6，7，8和9可以具有和n + m的和至少为3， 优选至少4，R <1>和R <2> C 1 -C 6 - 烷基，C 5 -C 7 - 环烷基或由式（I）的化合物（I）反应的C6-C12-芳基，其中R <1>，R <2>，m和n是和R腈，羧酰胺和羧酸基团的意思是在有机液体稀释剂的液相中存在的水，其特征在于：a）化合物（I如上文所定义 ）（与在液相中（在有机液体稀释剂III的存在水）的混合物IV），其包括内酰胺（II），反应，所述混合物（得到的两两相体系IV）水溶液后处理。

公开(公告)号：WO01056984A1

公开(公告)日：2001-08-09

申请号：PCT/NL2001/000081

申请日：2001-02-02

IPC: C07D201/08 ,  C07D201/12

CPC classification number: C07D201/08 ,  C07D201/12

Abstract: A process for the preparation of epsilon -caprolactam starting from 6-aminocaproic acid, 6-aminocaproamide, 6-aminocaproic ester, 6-aminocapronitrile, oligomers or polymers of these compounds or mixtures comprising at least two of these compounds, which process is performed in the presence of N-(5-carboxypentyl)- epsilon -caprolactam and/or derivative thereof in an amount of less than 50 wt.% and more than 0.1 wt.% (based on the total reaction mixture).

Abstract translation: 从6-氨基己酸，6-氨基己酰胺，6-氨基己酸酯，6-氨基己腈，这些化合物的低聚物或聚合物或包含这些化合物中的至少两种的混合物制备ε-己内酰胺的方法，该方法在 N-（5-羧戊基） - ε-己内酰胺和/或其衍生物的存在量小于50重量％且大于0.1重量％（基于总反应混合物）。

公开(公告)号：WO01025195A1

公开(公告)日：2001-04-12

申请号：PCT/US2000/027447

申请日：2000-10-05

IPC: C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/582

Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprise: a) converting one or more substituted or unsubstituted hydroxyaldehydes, e.g., 6-hydroxyhexanal, optionally in the presence of a catalyst or a catalyst and promoter, to one or more substituted or unsubstituted hydroxyamides, e.g. 6-hydroxycaproamide, and/or one or more substituted or unsubstituted epsilon caprolactam precursors, e.g., 6-aminocaproamide, epsilon caprolactone, epsilon caprolactone oligomers and esters of 6-hydroxycaproic acid and mixtures thereof; and b) converting said one or more substituted or unsubstituted hydroxamides and/or said one or more substituted or unsubstituted epsilon caprolactam precursors, optionally in the presence of a catalyst or a catalyst and promoter, to said one or more substituted or unsubstituted epsilon caprolactams; wherein the amount of byproducts resulting from reduction and/or reductive amination of said one or more substituted or unsubstituted hydroxyaldehydes, e.g., 1,6-hexanediol, aminohexanol, and the like, is no greater than about 10 weight percent, preferably no greater than about 5 weight percent, and more preferably no greater than about 1 weight percent, of the total of said one or more substituted or unsubstituted hydroxyamides and/or one or more substituted or unsubstituted epsilon caprolactam precursors. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as principal product(s) of reaction.

Abstract translation: 本发明部分涉及生产一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：a）任选地在催化剂存在下，将一种或多种取代或未取代的羟基醛例如6-羟基己醛转化 或催化剂和促进剂，与一种或多种取代或未取代的羟基酰胺，例如， 6-羟基己酰胺，和/或一种或多种取代或未取代的ε-己内酰胺前体，例如6-氨基己酰胺，ε己内酯，ε-己内酯低聚物和6-羟基己酸的酯及其混合物; 和b）任选地在催化剂或催化剂和促进剂的存在下，将所述一种或多种取代或未取代的羟基酰胺和/或所述一种或多种取代或未取代的己内酰胺前体转化为所述一种或多种取代或未取代的ε己内酰胺; 其中所述一种或多种取代或未取代的羟基醛（例如1,6-己二醇，氨基己醇等）的还原和/或还原胺化产生的副产物的量不大于约10重量％，优选不大于 所述一个或多个取代或未取代的羟基酰胺和/或一个或多个取代或未取代的ε-己内酰胺前体的总量的约5重量％，更优选不大于约1重量％。 本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为主要反应产物的反应混合物。

公开(公告)号：WO00047557A1

公开(公告)日：2000-08-17

申请号：PCT/NL2000/000068

申请日：2000-02-03

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Process for the preparation of epsilon -caprolactam comprising treating 6-aminocaproic acid, 6-aminocaproate ester, 6-aminocaproamide, oligomers or polymers of these compounds or mixtures comprising at least two of these compounds in a cyclisation reactor in the presence of superheated steam in which a gaseous product stream comprising epsilon -caprolactam, lights and heavies is obtained, wherein the product stream, after condensation and at least partial removal of water and lights, is split into a epsilon -caprolactam stream and a heavies stream containing heavies and epsilon -caprolactam and the heavies stream is recycled to a cyclisation reactor.

Abstract translation: 包括在过热蒸汽存在下在环化反应器中处理6-氨基己酸，6-氨基己酸酯，6-氨基己酰胺，这些化合物的低聚物或包含这些化合物的至少两种的混合物的ε-己内酰胺的制备方法 其中获得包含ε-己内酰胺，光和重质物的气态产物流，其中在冷凝和至少部分除去水和光之后，产物流被分裂成ε-己内酰胺流和含有重质和ε- 己内酰胺和重质物流再循环至环化反应器。

公开(公告)号：WO00014062A1

公开(公告)日：2000-03-16

申请号：PCT/NL1999/000544

申请日：1999-09-01

IPC: C07D223/10 ,  B01J23/46 ,  C07B61/00 ,  C07C227/08 ,  C07C229/08 ,  C07C231/14 ,  C07C237/06 ,  C07D201/08

CPC classification number: C07C227/08 ,  C07C231/14 ,  C07D201/08 ,  Y02P20/52

Abstract: Process for preparing an aqueous mixture of epsilon -caprolactam and 6-aminocaproic acid and or 6-aminocaproamide which involves, as the reductive amination step, contacting 5-formylvaleric acid and/or an alkyl 5-formylvalerate in water as solvent with hydrogen and an excess of ammonia in the presence of a ruthenium on carrier, as a catalyst, wherein the carrier is titanium oxide, zirconium oxide, graphite or carbon and the catalyst also contains at least one of the metals of group 8-11, or a compound of these metals. The aqueous mixture can be used to prepare epsilon -caprolactam.

Abstract translation: 制备ε-己内酰胺和6-氨基己酸和/或6-氨基己酰胺的水性混合物的方法，其涉及作为还原胺化步骤的5-甲酰基戊酸和/或作为溶剂的5-甲酰基戊酸烷基酯与氢气和 在载体上的钌存在下，过量的氨作为催化剂，其中载体是氧化钛，氧化锆，石墨或碳，催化剂还含有至少一种第8-11族的金属或 这些金属。 含水混合物可用于制备ε-己内酰胺。

公开(公告)号：WO00004994A1

公开(公告)日：2000-02-03

申请号：PCT/FR1999/001729

申请日：1999-07-15

IPC: C07D223/10 ,  B01J21/04 ,  B01J21/20 ,  B01J35/10 ,  B01J38/12 ,  B01J38/14 ,  B01J38/16 ,  B01J38/20 ,  C07B61/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  B01J38/12 ,  Y02P20/584

Abstract: The invention concerns a method for reactivating a catalyst for cyclizing hydrolysis of an aminonitrile for making lactams. More particularly, it concerns the reactivation of solid catalysts used in processes for producing lactams by cyclizing hydrolysis of aminonitriles. Said reactivating method consists in treating the spent catalyst at a temperature ranging between 300 DEG C and 600 DEG C with an oxidizing atmosphere.

Abstract translation: 本发明涉及一种用于再活化催化剂以环化氨基腈水解制备内酰胺的方法。 更具体地说，它涉及通过环化氨基腈水解生产内酰胺的方法中所用的固体催化剂的再活化。 所述再活化方法在于在300℃至600℃的温度下用氧化气氛处理废催化剂。

公开(公告)号：WO99051568A2

公开(公告)日：1999-10-14

申请号：PCT/US1999/006822

申请日：1999-03-29

IPC: C07D261/08 ,  C07B61/00 ,  C07C253/00 ,  C07C255/17 ,  C07C255/40 ,  C07D201/08

CPC classification number: C07C253/00 ,  C07D201/08 ,  C07C255/17 ,  C07C255/40

Abstract: The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

Abstract translation: 本发明涉及一种生产用作在一系列重要的生物分子，的制备合成中间体的α-芳基-β-酮腈的方法，如促肾上腺皮质激素释放因子（CRF）拮抗剂。

公开(公告)号：WO98050355A1

公开(公告)日：1998-11-12

申请号：PCT/EP1998/002571

申请日：1998-04-30

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: The invention relates to a method for producing cyclic lactams of formula (I), in which R stands for a hydrogen atom, an alkyl, a cycloalkyl or an aryl; A stands for a C3-C12-alkylene radical, which can be substituted by 1, 2, 3, 4, 5 or 6 substituents, selected independently from each other from the alkyl, cycloalkyl or aryl groups. In this method, a omega -amino carbonic acid nitrile of formula (II) HR N - A - CN, in which R and A have the meaning given above, is reacted in the presence of at least one catalyst. The method is characterized in that nitrile II is converted into an oligomer mixture and then treated with overheated water vapour.

Abstract translation: 本发明涉及一种用于制备式（I）的环状内酰胺，其中R <1>代表氢原子，烷基，环烷基或芳基; A为C 3 -C 12 - 亚烷基基团可以由1 5取代，2，3，4，或独立地6个取代基选自烷基，环烷基或芳基; 由式的欧米加-Aminocarbonsäurenitrils（II）的反应：HR <1> N - A - CN，其中R <1>和A具有上述含义，在至少一种催化剂，其特征在于，所述腈的存在下 II得到的低聚物，随后用过热蒸汽处理。

公开(公告)号：WO1997030973A1

公开(公告)日：1997-08-28

申请号：PCT/NL1997000056

申请日：1997-02-12

Applicant: DSM N.V. ,  E.I. DU PONT DE NEMOURS AND COMPANY ,  GUIT, Rudolf, Philippus, Maria ,  LANE, Samuel Livingston ,  BUIJS, Wim

Inventor： DSM N.V. ,  E.I. DU PONT DE NEMOURS AND COMPANY

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Process to prepare epsilon -caprolactam starting from a liquid aqueous mixture containing an alcohol and 6-aminocaproic acid by cyclization of 6-aminocaproic acid in the aqueous mixture at an elevated temperature. The alcohol is separated from the starting aqueous mixture before performing the cyclization to such extent that the concentration of alcohol in the aqueous mixture during the cyclization is less than 1 wt.%. The advantages include reduced amounts of undesirable by-product.

Abstract translation: 通过在高温下在含水混合物中环化6-氨基己酸，从含有醇和6-氨基己酸的液体含水混合物中制备ε-己内酰胺的方法。 在进行环化之前，将醇与起始含水混合物分离，使得在环化过程中含水混合物中醇的浓度小于1重量％。 优点包括减少不希望的副产物的量。

公开(公告)号：WO1996036600A1

公开(公告)日：1996-11-21

申请号：PCT/EP1996001891

申请日：1996-05-07

Applicant: BASF AKTIENGESELLSCHAFT ,  FUCHS, Eberhard ,  WITZEL, Tom ,  FLICK, Klemens

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Production of cyclic lactams by the reaction of amino carboxylic acid nitriles with water, performed in the liquid phase in the presence of heterogeneous catalysts based on titanium dioxide with a rutile content in the range from 0.1 to 95 wt.% and an anatase content in the range from 99.9 to 5 wt.% in relation to the total titanium dioxide content.

Abstract translation: 通过基于与在0.1的范围内的金红石含量至95重量％，在99的范围内的锐钛型含量的二氧化钛在非均相催化剂的存在下与水的氨基腈，在液相中反应而制备的环状内酰胺， 9到5重量％，各自基于二氧化钛的总含量的工作。