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公开(公告)号：WO2019213028A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/029817
申请日：2019-04-30
Inventor： FOSTER, Alexander, Brett , KENNEDY, Jonathan
IPC: C07K14/195 , C12N15/52 , C12P1/04 , C12P7/04 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/64 , C12P13/00 , C12P13/04 , C12N9/06 , C12N9/00 , C12N9/12 , C12N9/14
Abstract: Methods for increasing carbon-based chemical product yield in an organism by genetically modifying one or more genes involved in a stringent response and/or in a regulatory network, nonnaturally occurring organisms having increased carbon-based chemical product yield, and methods for use in production of carbon-based chemical products are provided.
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2.发明申请MATERIALS AND METHODS UTILIZING BIOTIN PRODUCING MUTANT HOSTS FOR THE PRODUCTION OF 7-CARBON CHEMICALS 审中-公开利用生物素生产突变体生产7-碳化合物的材料和方法
公开(公告)号：WO2018022595A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043682
申请日：2017-07-25
Abstract: Disclosed are methods for regulating biosynthesis of at least one of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, 7-arninoheiptanol and 1,7-heptanediol (C7 building blocks) using a pathway having a pimeloyl-ACP intermediate, the method including the step of downregulating the activity of BioF. Also disclosed are recombinant hosts by fermentation in which the above methods are performed. Further disclosed are recombinant hosts for producing pimeloyl-ACP, the recombinant host including a deletion of a bioF gene.
Abstract translation: 公开了用于调节庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺，7-氨基海帕醇和1,7-庚二醇（C7结构单元）中的至少一种的生物合成的方法， 该途径具有庚二酰-ACP中间体，该方法包括下调BioF活性的步骤。 还公开了通过发酵进行上述方法的重组宿主。 还公开了用于产生庚二酰基-ACP的重组宿主，该重组宿主包括bioF基因的缺失。
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公开(公告)号：WO2019213019A8
公开(公告)日：2019-11-07
申请号：PCT/US2019/029798
申请日：2019-04-30
Inventor： FOSTER, Alexander, Brett , ROBERT, Ana Teresa Dos Santos Brito, Mendes , BARMAN, Arghya , KENNEDY, Jonathan
IPC: C07K14/195 , C12N15/52 , C12P5/02 , C12P7/04 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/64 , C12P13/00 , C12P13/04 , C12P1/04
Abstract: Methods for increasing carbon-based chemical product yield in an organism by increasing carbon uptake and/or altering a pathway to or from an overflow metabolite in the organism, nonnaturally occurring organisms having increased carbon-based chemical product yield with increased carbon uptake and/or an altered pathway to or from an overflow metabolite, and methods for producing a carbon-based chemical product with these organisms are provided.
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公开(公告)号：WO2019152757A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016219
申请日：2019-02-01
Inventor： FRITSCH, Emilie, Sophie , FOSTER, Alexander, Brett
Abstract: Methods and materials for the production of compounds involved in the TCA cycle, and/or derivatives thereof and/or compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials.
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公开(公告)号：WO2019213019A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/029798
申请日：2019-04-30
Inventor： FOSTER, Alexander, Brett , ROBERT, Ana Teresa Dos Santos Brito, Mendes , BARMAN, Arghya , KENNEDY, Jonathan
IPC: C07K14/195 , C12N15/52 , C12P5/02 , C12P7/04 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/64 , C12P13/00 , C12P13/04 , C12P1/04
Abstract: Methods for increasing carbon-based chemical product yield in an organism by increasing carbon uptake and/or altering a pathway to or from an overflow metabolite in the organism, nonnaturally occurring organisms having increased carbon-based chemical product yield with increased carbon uptake and/or an altered pathway to or from an overflow metabolite, and methods for producing a carbon-based chemical product with these organisms are provided.
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Patent Agency Ranking
公开(公告)号：WO2019152753A8
公开(公告)日：2019-08-08
申请号：PCT/US2019/016211
申请日：2019-02-01
Inventor： COMBE, Jonathan, Paul , FOSTER, Alexander, Brett , BARMAN, Arghya
Abstract: Methods and materials for the production of hydroxy fatty acid anions, including 2-hydroxyisobutyric acid (2-HIBA), and/or derivatives thereof and compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials.
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公开(公告)号：WO2019006257A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040218
申请日：2018-06-29
Applicant: INVISTA NORTH AMERICA .S.A.R.L.
Inventor： FOSTER, Alexander, Brett , PATTENDEN, Leonard, Keith , RAND, Jonathan, David , ROBERTS, Ana Teresa Dos Santos Brito, Mendes , SHAW, Andrew , TAYLOR, Mark, Paul
CPC classification number: C12P5/007 , C12N1/20 , C12N9/1022 , C12N9/88 , C12Y202/01007 , C12Y402/03027
Abstract: Disclosed herein are methods, compositions, and hosts for synthesizing hydrocarbons, and derivatives thereof, comprising one or more isoprene units as well as salts or derivatives thereof. An aspect of the present invention thus relates to a method for biosynthesizing hydrocarbons in a recombinant host selected from non-pathogenic members of the genera Ralstonia, Wausteria, Cupriavidus, Alcaligenes, Burkholderia, or Pandoraea. Said recombinant host comprises an exogenous nucleic acid sequence encoding a polypeptide having an enzyme activity selected from 1-deoxy-D-xylulose-5-phosphate synthase (DXS) activity (EC 2.2.1.7) and isoprene synthase enzyme activity (EC 4.2.3.27).
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公开(公告)号：WO2019213033A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/029827
申请日：2019-04-30
Inventor： FOSTER, Alexander, Brett , FRITSCH, Emilie, Sophie
IPC: C12N15/52 , C12N9/88 , C12N9/00 , C12N9/10 , C12P7/56 , C12P7/06 , C12P7/28 , C12P7/54 , C12P7/46 , C12P7/42 , C12P7/18 , C12P7/48 , C12P7/44 , C12P13/14 , C12P13/00 , C12P13/08 , C12P1/04
Abstract: Methods of redirecting carbon flux and increasing C2/C3 or a C4/5/6 carbon chain length carbon-based chemical product yield in an organism, nonnaturally occurring organisms with redirected carbon flux and increased C2/C3 or C4/5/6 carbon chain length carbon-based chemical product yield and methods for using these organisms in production of C2/C3 or C4/5/6 carbon chain length carbon-based chemical products are provided.
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公开(公告)号：WO2019213017A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/029795
申请日：2019-04-30
Inventor： FOSTER, Alexander, Brett , COMBE, Jonathan, Paul , BARMAN, Arghya
IPC: C12N1/20 , C12N9/88 , C12N9/04 , C12N15/52 , C12N9/12 , C12N9/02 , C12N9/06 , C12N9/10 , C12N9/00 , C12P5/02 , C12P7/04 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P13/04 , C12P13/00 , C12P7/64 , C12P1/04
Abstract: Methods for increasing carbon-based chemical product yield in an organism by perturbing redox balance in an organism as well as nonnaturally occurring organisms with perturbed redox balance and methods for their use in producing carbon-based chemical products are provided.
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10.发明申请
公开(公告)号：WO2019152755A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016217
申请日：2019-02-01
Abstract: Methods and materials for the production of beta hydroxy acids, such as 3-hydroxypropanoic acid (3-HP) and/or derivatives thereof and/or compounds related thereto, are provided. Also provided are products produced in accordance with these methods and materials.
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