公开(公告)号：WO2013090837A2

公开(公告)日：2013-06-20

申请号：PCT/US2012/069934

申请日：2012-12-14

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： BOTES, Adriana ,  CONRADIE, Alex van Eck

IPC: C12P7/18 ,  C12P7/44 ,  C12P17/10 ,  C12P13/00

CPC classification number: C12P7/44 ,  C12N15/52 ,  C12P7/18 ,  C12P13/001 ,  C12P13/005 ,  C12P17/10

Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.

Abstract translation: 该文献描述了通过在C6脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延伸酶或类似物与聚羟基链烷酸酯累积细菌的碳储存途径相关的酶。