The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: or (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH2 or SC2, X represents an alkyl group, alkyl group having a hetero atom-as a substitution group, an aryl-group or an acyl group, m represents an integer of 1 to 5, and R1, R2, R3 and R4 independently represent hydrogen alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-l inhibitory action, antioxidation action and-bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.