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    2.
    发明专利
    未知

    公开(公告)号：DE69323070T2

    公开(公告)日：1999-05-20

    申请号：DE69323070

    申请日：1993-10-29

    Applicant: TORAY INDUSTRIES

    Inventor： TAKANISHI KEIJIRO ,  KAWABE NORIO ,  NAKADATE TERUO

    IPC: A61K31/67 ,  A61P3/00 ,  A61P29/00 ,  C07D335/06 ,  C07F9/6553

    Abstract: A methanediphosphonate derivative represented by general formula (1), wherein R1, R2, R3 and R4 represent each independently a pharmacologically acceptable cation, hydrogen, or C1-C4 linear or branched alkyl; R5 represents hydrogen or trialkylsilyl; m represents an integer of 0 to 3; n represents an integer of 1 to 3; R6 and R7 represent each independently hydrogen or alkyl; X represents hydrogen, halogen, alkyl, alkoxy or alkylthio. This compound is excellent in anti-inflammatory effect, antipyretic and analgesic effects or the effect of ameliorating bone anomaly caused by rheumatism, arthritis, osteoporosis and so forth, thus being useful as anti-inflammatory, antirheumatic and a remedy for bone metabolism disorder.

    METHANEDIPHOSPHONATE DERIVATIVE, ITS MANUFACTURING PROCESS AND ITS PHARMACEUTICAL APPLICATIONS
    3.
    发明专利
    METHANEDIPHOSPHONATE DERIVATIVE, ITS MANUFACTURING PROCESS AND ITS PHARMACEUTICAL APPLICATIONS 未知

    公开(公告)号：CA2095128C

    公开(公告)日：1998-01-06

    申请号：CA2095128

    申请日：1992-09-07

    Applicant: TORAY INDUSTRIES

    Inventor： ITO MASATOSHI ,  TANAHASHI MASAHIKO ,  KAWABE NORIO ,  UCHIRO HIROMI ,  NAKADATE TERUO

    IPC: A61K31/66 ,  A63C11/22 ,  A63C11/24 ,  C07F9/38 ,  C07F9/40 ,  C07F9/547 ,  A61K31/695

    Abstract: The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: or (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH2 or SC2, X represents an alkyl group, alkyl group having a hetero atom-as a substitution group, an aryl-group or an acyl group, m represents an integer of 1 to 5, and R1, R2, R3 and R4 independently represent hydrogen alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-l inhibitory action, antioxidation action and-bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.

    5.
    发明专利
    未知

    公开(公告)号：FI944998A

    公开(公告)日：1994-10-24

    申请号：FI944998

    申请日：1994-10-24

    Applicant: TORAY INDUSTRIES

    Inventor： TAKANISHI KEIJIRO ,  UCHIRO HIROMI ,  KAWABE NORIO

    IPC: B01J21/10 ,  B01J23/06 ,  B01J23/72 ,  C07B61/00 ,  C07F9/38 ,  C07F9/40 ,  C07F

    Abstract: A process for producing a 1-alkylthio- or 1-arylthiomethanediphosphonate compound by conducting the coupling reaction represented by formula (I) in the presence of a metallic oxide, wherein four R'1 groups represent each independently C1-C6 linear or branched alkyl; four R1 groups represent each independently a pharmacologically acceptable cation, hydrogen or C1-C6 linear or branched alkyl; and R2 represents alkyl or aryl. This process is extremely useful from the economic and industrial points of view, because the yield is remarkably improved and accordingly the purification procedure is simplified as compared with the conventional ones.

    DRY PLANOGRAPHIC PRINTING PLATE AND PREPARATION THEREOF
    8.
    发明专利
    DRY PLANOGRAPHIC PRINTING PLATE AND PREPARATION THEREOF 未知

    公开(公告)号：CA1164267A

    公开(公告)日：1984-03-27

    申请号：CA365953

    申请日：1980-12-02

    Applicant: TORAY INDUSTRIES

    Inventor： KINASHI TAKAO ,  FUJITA TAKASHI ,  KAWABE NORIO

    IPC: G03F7/09 ,  G03F7/00 ,  G03F7/075 ,  B41N1/00 ,  G03C1/68

    Abstract: A presensitized planographic printing master plate is provided herein requiring no dampening water for use in negative work. The plate comprises a base substrate, a light releasing photosensitive layer overlying the base substrate and a silicone rubber layer overlying the photosensitive layer. When the printing master plate is exposed through a negative film and then is treated with a developer, only the silicone rubber layer overlying the exposed photosensitive layer is removed, while the photosensitive layer remains as it is to form an image area. Dampening water is not required when printing is carried out.

    FARMACOS PARA ENFERMEDADES PERIODONTALES.
    9.
    发明专利
    FARMACOS PARA ENFERMEDADES PERIODONTALES. 未知

    公开(公告)号：ES2337545T3

    公开(公告)日：2010-04-27

    申请号：ES00946395

    申请日：2000-07-19

    Applicant: TORAY INDUSTRIES

    Inventor： ITO MASATOSHI ,  OKAZAKI SEIJI ,  KAWAI YURIKO ,  KAWABE NORIO

    IPC: A61K31/663 ,  A61P1/02

    Abstract: Utilización de un derivado del ácido metanobisfosfónico, o un hidrato del mismo, para la fabricación de un medicamento para el tratamiento o la profilaxis de la enfermedad periodontal, en el que el derivado del ácido metanobisfosfónico, o un hidrato del mismo, se representan mediante la siguiente fórmula general (I): **(Ver fórmula)** en el que X es un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, un grupo fenilo o un grupo naftilo, en el que dicho grupo alquilo está no sustituido o sustituido con un sustituyente que tiene un átomo de nitrógeno, oxígeno o silicio, y en el que dichos grupos fenilo y naftilo pueden estar sustituidos con un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, un grupo alcoxi de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, halógeno, o un grupo hidroxilo; Y es un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, un grupo trifluorometilo, un grupo alquenilo de cadena lineal o ramificada que tiene de 2 a 8 átomos de carbono, un grupo cicloalquilo que tiene de 3 a 8 átomos de carbono, un grupo alcoxi que tiene de 1 a 8 átomos de carbono o halógeno, excluyendo cloro, sustituido en la posición para; cada uno de m y n es independientemente 0, 1, 2, ó 3; * indica un doble enlace o un enlace simple; A es (D)b-(CH2)c- o -(CH=CH)d-CH=, en el que D es azufre, oxígeno, NR5 o CH2, en el que R5 es hidrógeno o un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, c es un número entero de 0 a 3, y b es 0 ó 1, en el que d es 0 ó 1, y en el que B no existe cuando A es -(CH=CH)d-CH=; B es hidrógeno, un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, un grupo hidroxilo o un grupo trialquilsiloxi, en que el residuo de dicho grupo alquilo es un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono; cada uno de R1, R2, R3 y R4 es, idéntico o diferente entre sí, hidrógeno, un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, o un catión farmacéuticamente aceptable.

    10.
    发明专利
    未知

    公开(公告)号：DE69529975T2

    公开(公告)日：2004-01-08

    申请号：DE69529975

    申请日：1995-12-22

    Applicant: TORAY INDUSTRIES

    Inventor： UCHIRO HIROMI ,  KAWABE NORIO ,  KAWANO TEIJI ,  TSURUTA KOUICHI

    IPC: C07C319/02 ,  C07C319/24 ,  C07C321/26 ,  C07C321/28

    Abstract: The present invention relates to a method of producing bis(4-alkylthiophenyl) disulfides characterized by (a) reducing directly a 4-alkylthiobenzenesulfonyl chloride, or (b) oxidizing a 4-alkylthiobenzenethiol obtained by reducing a 4-alkylthiobenzenesulfonyl chloride. The present invention is capable of producing the compound below useful as an intermediate of pharmaceuticals.

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