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公开(公告)号：DK0594857T3
公开(公告)日：1998-10-07
申请号：DK92918702
申请日：1992-09-07
Applicant: TORAY INDUSTRIES
Inventor： KAWABE NORIO , UCHIRO HIROMI , NAKADATE TERUO , TANAHASHI MASAHIKO , ITO MASATOSHI
Abstract: A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R , R , R and R represent each independently hydrogen, C1 to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.
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公开(公告)号：ES2114946T3
公开(公告)日：1998-06-16
申请号：ES92918702
申请日：1992-09-07
Applicant: TORAY INDUSTRIES
Inventor： KAWABE NORIO , UCHIRO HIROMI , NAKADATE TERUO , TANAHASHI MASAHIKO , ITO MASATOSHI
Abstract: A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R , R , R and R represent each independently hydrogen, C1 to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.
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公开(公告)号：DE69225325D1
公开(公告)日：1998-06-04
申请号：DE69225325
申请日：1992-09-07
Applicant: TORAY INDUSTRIES
Inventor： KAWABE NORIO , UCHIRO HIROMI , NAKADATE TERUO , TANAHASHI MASAHIKO , ITO MASATOSHI
Abstract: A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R , R , R and R represent each independently hydrogen, C1 to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.
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公开(公告)号：CA2344313C
公开(公告)日：2007-11-27
申请号：CA2344313
申请日：2000-07-19
Applicant: TORAY INDUSTRIES
Inventor： ITO MASATOSHI , OKAZAKI SEIJI , KAWAI YURIKO , KAWABE NORIO
IPC: A61K31/663 , A61P1/02
Abstract: An agent for periodontal disease includes, as an active component, a methanebisphosphonic acid derivative or a hydrate thereof represented by the general formula (I): (see Formula I) [wherein X, Y, m, n, ~, A, B, R1, R2, R3 and R4 have the same meanings as defined in the description] The methanebisphosphonic acid derivative represented by the general formula (I) or a hydrate thereof according to the present invention has activities such as inhibitory effect on cell infiltration to the affected part associated with periodontal disease, and is useful for the prophylaxis or treatment of periodontal disease.
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公开(公告)号：CA2346014A1
公开(公告)日：2001-02-08
申请号：CA2346014
申请日：2000-07-26
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI MASAHIKO , OKAZAKI SEIJI , ITO MASATOSHI , KIM KANG JUNG , KAWAI YURIKO , IWASE MIHO
Abstract: Insertion stabilizers for implants which contain as the active ingredient methanebisphosphonic acid derivatives represented by general formula (I) or hydrates thereof wherein X, Y, m, n, ---, A, B, R1, R2, R3 and R4 are each as defined in the description. The above-described methanebisphosphonic acid derivatives represented by general formula (I) or hydrates thereof have an effect of inhibiting the proliferation of interstitial tissues or an effe ct of inhibiting the production of osteolytic factors and therefore particularl y inhibit the proliferation of interstitial tissues associating the insertion of an implant and inhibit the production of osteolytic factors around the impla nt to thereby inhibit osteolysis. Owing to these characteristics, these compoun ds are effective in preventing implants from loosening or fall-off and thus mak e it possible to prolong the insertion period of implants such as artificial joints and dental implants.
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Patent Agency Ranking
公开(公告)号：CA2321864A1
公开(公告)日：2000-07-06
申请号：CA2321864
申请日：1999-06-23
Applicant: TORAY INDUSTRIES
Inventor： ITO MASATOSHI , TANAHASHI MASAHIKO , OKAZAKI SEIJI , FUNABA YURIKO , KOIKE JUNZO
IPC: A61K31/675 , A61K31/66
Abstract: Drugs effective in the prevention and treatment of diseases due to abnormal production of interleukin-6, which are interleukin-6 production inhibitors containing as the active ingredient methanebis-phosphonic acid derivatives and exhibit an inhibitory effect against the production of interleukin-6. These drugs can be expected to be effective in the prevention and treatment of diseases in which interleukin-6 participates, for example, thrombocytosis, inflammatory diseases, immune response disorders, osteoporosis, rheumatoid arthritis, hypercalcemia, multiple myeloma, cachexia and nephritis.
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公开(公告)号：CA2281937A1
公开(公告)日：1999-07-08
申请号：CA2281937
申请日：1998-12-24
Applicant: TORAY INDUSTRIES
Inventor： FUNABA YURIKO , ITO MASATOSHI , OKAZAKI SEIJI , KOIKE JUNZO , TANAHASHI MASAHIKO
IPC: A61K31/66 , A61K31/675
Abstract: Remedies for intramedullary diseases which are efficacious in correcting intramedullary biological balance, in particular, preventing inflammatory cellular infiltration and preventing increase in cell proliferation factors. These remedies contain as the active ingredient methanebisphosphonic acid derivatives, esters thereof, pharmaceutically acceptable salts thereof or hydrates of the same. Because of showing excellent therapeutic effects on intramedullary diseases, the above derivatives are expected as useful in preventing and treating intramedullary diseases such as rheumatoid arthritis, multiple myeloma and osteomyelitis. These compounds are also expected as useful in preventing and treating diseases of the hematopoietic system such as aplastic anemia and myelocytic leukemia.
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8.发明专利
公开(公告)号：CA2095128A1
公开(公告)日：1993-03-06
申请号：CA2095128
申请日：1992-09-07
Applicant: TORAY INDUSTRIES
Inventor： KAWABE NORIO , NAKADATE TERUO , ITO MASATOSHI , UCHIRO HIROMI , TANAHASHI MASAHIKO
Abstract: A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R , R , R and R represent each independently hydrogen, C1 to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth.
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公开(公告)号：DE60043648D1
公开(公告)日：2010-02-25
申请号：DE60043648
申请日：2000-07-19
Applicant: TORAY INDUSTRIES
Inventor： ITO MASATOSHI , OKAZAKI SEIJI , KAWAI YURIKO , KAWABE NORIO
IPC: A61K31/663 , A61P1/02
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10.发明专利
公开(公告)号：CA2095128C
公开(公告)日：1998-01-06
申请号：CA2095128
申请日：1992-09-07
Applicant: TORAY INDUSTRIES
Inventor： ITO MASATOSHI , TANAHASHI MASAHIKO , KAWABE NORIO , UCHIRO HIROMI , NAKADATE TERUO
Abstract: The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: or (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH2 or SC2, X represents an alkyl group, alkyl group having a hetero atom-as a substitution group, an aryl-group or an acyl group, m represents an integer of 1 to 5, and R1, R2, R3 and R4 independently represent hydrogen alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-l inhibitory action, antioxidation action and-bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.
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