The invention relates to an internal combustion engine with two-stage supercharging capability and with exhaust-gas aftertreatment arrangement, and a method for operating an internal combustion engine of said type. The supercharged internal combustion engine includes at least two exhaust-gas turbochargers arranged in series, wherein a first exhaust-gas turbocharger serves as a low-pressure stage and a second exhaust-gas turbocharger serves as a high-pressure stage. A second turbine of the second exhaust-gas turbocharger may be present upstream of a first turbine of the first exhaust-gas turbocharger, and a second compressor of the second exhaust-gas turbocharger may be arranged in an intake system downstream of a first compressor of the first exhaust-gas turbocharger and a first bypass line may branch off upstream of the second turbine and join back at a junction point between the first turbine and the second turbine.