The invention relates to an N-benzyl nitro heterocyclic ketene aminal derivative, a synthesis method and antitumor application. The structure of the compound is shown as the formula (I) (shown in the description), wherein in the formula (I), X is a fluorine and chlorine atom, Ar is phenyl, monofluorodiphenyl, monochlorinated phenyl, trifluoromethyl substituted phenyl, nitro substituted phenyl, cyanyl substituted phenyl, 2,4-difluorobenyl, 3,5-difluorobenyl, 2,6-difluorophenyl, methyl substituted phenyl, methoxyl substituted phenyl, pyridyl, substituted pyridyl or thiophenyl or substituted thiophenyl. The N-benzyl nitro heterocyclic ketene aminal derivative has the excellent anti-tumor activity to human lung cancer (A549), human colon cancer (HT29), human gastric cancer (SGC7901) and human liver cancer (HepG2). The inhibitory activity of the compound to the human lung cancer (A549) is better than that of a control drug cisplatin. The N-benzyl nitro heterocyclic ketene aminal derivative has a wide application prospect in the preparation of anti-tumor drugs.