The invention relates to a vacuum assisted resin infusion device for base bodies of high-speed and ultra high-speed grinding wheels. The vacuum assisted resin infusion device comprises a base plate, a lower flow guide structure, an internal film and an external film, wherein the lower flow guide structure is used for resin flow guiding in the transverse and longitudinal directions and arranged on the base plate, and the internal film and the external film are arranged on the base plate internally and externally; the internal film is connected with a resin-injection pipeline, an upper flow guide structure is arranged between the tops of the internal film and the external film, wherein the upper flow guide structure is used for vacuum flow guiding in the transverse and longitudinal directions; and a top-surface vacuumizing port communicating with the upper flow guide structure is formed in the top of the external film, and at least one side-surface vacuumizing port is formed in the side surface of the side, opposite to the resin-injection pipeline, of the external film. According to the vacuum assisted resin infusion device, a side-portion flow guide net does not need to be arranged, instead, the side-surface vacuumizing ports and the top-surface vacuumizing port are formed correspondingly, and gas is extracted out in the transverse direction and the longitudinal direction; and the structural arrangement is simple, the situation that the internal gas is extracted out from the side-portion flow guide net in the obliquely upward direction is avoided, and the wear and tear of vacuumizing equipment is reduced.