Systems, apparatuses, and methods for implementing per-page control of physical address space distribution among memory modules are disclosed. A computing system includes a plurality of processing units coupled to a plurality of memory modules. A determination is made as to which physical address space distribution granularity to implement for physical memory pages allocated for a first data structure. The determination can be made on a per-data-structure basis (e.g., file, page, block, etc.) or on a per-application-basis. A physical address space distribution granularity is encoded as a property of each physical memory page allocated for the first data structure, and physical memory pages of the first data structure distributed across the plurality of memory modules based on a selected physical address space distribution granularity. Page table entries (PTEs) may be annotated with the selected physical address space distribution granularity, using an addressing mapping granularity (AMG) field of a page table entry, where the granularity may be, for example, a fine-grain distribution granularity or a coarse-grain distribution granularity.