A sterile work can be applied by a worker 29 to cells or the like through a glove 28 provided in an isolator 15. A work headset 31 outputting a work procedure of the sterile work vocally is prepared for the worker, and a check input device 39 is prepared for a checker 36. A management device 12 outputs the work procedure of the sterile work this time vocally to the work headset. When the fact that the worker has normally performed the sterile work this time is checked by the checker, and when the fact is input from the check input device to the management device, the management device performs the subsequent work procedure. Since the sterile work by the worker 29 can be monitored by the checker 36, a wrong work can be prevented from being performed.