A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.