Abstract:
A fiber optic probe includes a first diffuse reflectance spectroscopy fiber, a second diffuse reflectance spectroscopy fiber, and a temperature sensor at a distal end of a temperature sensor fiber. Other embodiments further include a treatment fiber for delivering a high optical power density of light to a tumor and a dosimetry fiber for monitoring the light flux of the treatment fiber. Other embodiments utilize an image-guidance step in a method of using the fiber optic probe.
Abstract:
The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
Abstract:
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
Abstract:
The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
Abstract:
In one embodiment, a microprocessor is provided. The microprocessor includes a cache that is controlled by a cache controller. The cache controller is configured to replace cachelines in the cache based on a replacement scheme that prioritizes the replacement of cachelines that are less likely to cause roll back of a transaction of the microprocessor.
Abstract:
Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.
Abstract:
The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According to one aspect, the subject matter described herein includes a multi-probe imaging array for contacting biological samples and simultaneously illuminating a plurality of locations on the biological sample and collecting the reflected radiation from the locations. The multi-probe imaging array can be used for the rapid imaging of biological samples, for example, during surgery.
Abstract:
A method in a video playback system for playing a video with a specific playback speed in accordance with a video feature and a playback record is described. The system allows the playback record records a preceding playback speed corresponding to the video previously played to learn user preferences for a user. This makes the specific playback speed more suitable for the user without any adjustment. In addition, the system also allows the user input a resetting playback speed to actively adjust the specific playback speed if the original specific playback speed is not suitable for the user.
Abstract:
A method for managing a product manufacturing process is disclosed. The method includes the steps of downloading a bill of materials of the product from a first database according to a serial number and an edition of the product; downloading a production order from a second database according to the production order number; downloading received materials delivery receipts from the second database according to corresponding numbers of the received materials delivery receipts; obtaining product information and manufacturing information of downloaded production order; obtaining serial numbers and editions of corresponding materials; obtaining received materials information from the downloaded received materials delivery receipts; creating a manufacturing check list according to obtained information; and saving the manufacturing check list in the application server, and creating a serial number of the manufacturing check list; assigning one or more preconfigured product tracking numbers to the manufacturing check list.
Abstract:
A controlled-release fertilizer having a fertilizer core and a coating applied thereon, the coating comprising a wax film layer and a polymer film layer. A method of preparation of the controlled-release fertilizer.