Systems and methods for determining a configuration for a microarchitecture are described herein. An example system includes a proposal generator to generate a first candidate configuration of parameters for the microarchitecture, a machine learning model to process the first candidate configuration of parameters to output estimated performance indicators for the microarchitecture, an uncertainty checker to determine whether the estimated performance indicators are reliable, and a performance checker. In response to a determination that the estimated performance indicators are reliable, the performance checker is to determine whether the estimated performance indicators have improved toward a target. Further, if the estimated performance indicators have improved, the performance checker is to store the first candidate configuration of parameters in a memory as a potential solution for a microarchitecture without performing a full simulation on the first candidate configuration of parameters.