Systems and methods are provided for correlating functional magnetic resonance imaging (fMRI) with gene expression. Brains of first and second sets of patients are imaged at first and second times to provide first and second sets of fMRI images. Blood is drawn from each of the first and second sets of patients at the first and second times to provide first and second sets of gene expression transcripts. A therapeutic is administered to the first set of patients between the first and second times. A change in the connectivity of the brain for each patient is determined from the first and second sets of fMRI images. A set of changes in the peripheral lymphocyte gene expression that are correlated with changes in the connectivity of the brain are determined from the change in the connectivity of the brain for each patient and the collected imaging and gene expression data.