A medical system comprising a hand-held imaging device comprising optical components including a light source to illuminate an area of medical interest, a liquid crystal variable retarder to receive light from the area of medical interest, and a retardance controller to provide a driving waveform to the variable retarder that controls retardance. The device also includes an image sensor configured to receive light from the variable retarder and to convert the received light into an output voltage signal for either the camera operation or the hyperspectral imaging operation, and communication circuitry configured to communicate imaging information based on the output voltage signal to a medical diagnostic system. The hand-held imaging device is configured to switchably perform a hyperspectral imaging and a camera operation such that the operations share at least one optical component. The diagnostic device is configured to receive the imaging information and to provide diagnostic information based thereon.