Methods, systems, and devices for pre-distortion of multi-level signaling are described. A device may identify two multi-level signals that are to be transmitted over two transmission lines at the same time. The device may estimate the crosstalk expected to be caused by one of the multi-level signals on the other during propagation. Based on the expected crosstalk, the device may generate a signal that compensates for the expected crosstalk. In some examples, the signal may be a combination of the first signal and a cancelation signal. In some examples, once the compensated signal has been generated, it is transmitted over its respective transmission line at the same time that the other multi-level is transmitted over its respective transmission line.