- Patent Title: Methods to identify immunogens by targeting improbable mutations
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Application No.: US17500750Application Date: 2021-10-13
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Publication No.: US11746143B2Publication Date: 2023-09-05
- Inventor: Barton F. Haynes , Kevin J. Wiehe , Mattia Bonsignori
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: DUKE UNIVERSITY
- Current Assignee: DUKE UNIVERSITY
- Current Assignee Address: US NC Durham
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/00 ; A61K39/12 ; A61K51/10 ; C07K14/005 ; C07K16/10 ; A61K39/21 ; G01N33/569
Abstract:
The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.
Public/Granted literature
- US20220185871A1 METHODS TO IDENTIFY IMMUNOGENS BY TARGETING IMPROBABLE MUTATIONS Public/Granted day:2022-06-16
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