公开(公告)号：US20250042980A1

公开(公告)日：2025-02-06

申请号：US18532709

申请日：2023-12-07

Applicant: Duke University

Inventor： Edward F. Patz, JR. ,  Michael J. Campa ,  Elizabeth Gottlin ,  Barton F. Haynes ,  Hua-Xin Liao ,  Michael Anthony Moody

IPC: C07K16/18 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

Abstract: Disclosed herein are Complement factor H (CFH) antibodies and methods of using the antibodies.

公开(公告)号：US20240252617A1

公开(公告)日：2024-08-01

申请号：US18276798

申请日：2022-02-10

Applicant: Duke University

Inventor： Kevin Saunders ,  Barton F. Haynes

IPC: A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C07K14/435

CPC classification number: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C07K14/435 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/50 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The invention is directed to coronavirus based immunogens, including immunogens comprising spike protein and or domains thereof, comprised in multimeric complexes. Provided are also methods of using these immunogens to induce immunogenic responses in a subject.

公开(公告)号：US11897946B2

公开(公告)日：2024-02-13

申请号：US17458019

申请日：2021-08-26

Applicant: Duke University

Inventor： Edward F. Patz, Jr. ,  Michael J. Campa ,  Elizabeth Gottlin ,  Barton F. Haynes ,  Hua-Xin Liao ,  M. Anthony Moody

IPC: A61K39/395 ,  C07K16/18 ,  C07K14/72 ,  G01N33/68 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/72 ,  G01N33/6872 ,  G01N33/6878 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/4716

Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.

公开(公告)号：US11773144B2

公开(公告)日：2023-10-03

申请号：US16753303

申请日：2018-10-02

Applicant: DUKE UNIVERSITY ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： Bette Korber ,  Sandrasegaram Gnanakaran ,  Guido Ferrari ,  Barton F. Haynes

IPC: C07K14/16 ,  A61K39/12 ,  A61K39/00

CPC classification number: C07K14/162 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/70

Abstract: The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.

公开(公告)号：US11746143B2

公开(公告)日：2023-09-05

申请号：US17500750

申请日：2021-10-13

Applicant: Duke University

Inventor： Barton F. Haynes ,  Kevin J. Wiehe ,  Mattia Bonsignori

IPC: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K51/10 ,  C07K14/005 ,  C07K16/10 ,  A61K39/21 ,  G01N33/569

CPC classification number: C07K16/1063 ,  A61K39/21 ,  C12N7/00 ,  G01N33/56983 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/92 ,  C12N2740/16034

Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.

公开(公告)号：US20230167178A1

公开(公告)日：2023-06-01

申请号：US17812492

申请日：2022-07-14

Applicant: MacroGenics, Inc. ,  Duke University

Inventor： Scott Koenig ,  Leslie S. Johnson ,  Chia-Ying Kao Lam ,  Liqin Liu ,  Jeffrey Lee Nordstrom ,  Barton F. Haynes ,  Guido Ferrari

IPC: C07K16/28 ,  C12N5/0783 ,  C07K16/10 ,  C07K16/08

CPC classification number: C07K16/283 ,  C12N5/0638 ,  C07K16/1027 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/084 ,  C07K16/085 ,  C12N2510/00 ,  C12N2710/16211 ,  C12N2710/20011 ,  C12N2740/16111 ,  C12N2760/18511 ,  C07K2317/626 ,  C07K2317/31 ,  C07K2317/73 ,  A61K2039/505

Abstract: The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.

公开(公告)号：US11246920B2

公开(公告)日：2022-02-15

申请号：US16081771

申请日：2017-03-03

Applicant: Duke University ,  Triad National Security, LLC

Inventor： Barton F. Haynes ,  Mattia Bonsignori ,  Bette T. Korber ,  Peter T. Hraber ,  Kevin Saunders

IPC: A61K39/12 ,  C12N7/00 ,  A61K39/00

Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.

公开(公告)号：US11161895B2

公开(公告)日：2021-11-02

申请号：US16337264

申请日：2017-10-03

Applicant: Duke University

Inventor： Barton F. Haynes ,  Kevin J. Wiehe ,  Mattia Bonsignori

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/395 ,  C07K16/00 ,  A61K39/21 ,  C12N7/00 ,  G01N33/569

Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.

公开(公告)号：US10849970B2

公开(公告)日：2020-12-01

申请号：US15864822

申请日：2018-01-08

Applicant: Duke University ,  Triad National Security, LLC ,  The Trustees of The University of Pennsylvania ,  Trustees of Boston University ,  The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： Barton F. Haynes ,  Hua-Xin Liao ,  Rebecca M. Lynch ,  Tongqing Zhou ,  Feng Gao ,  Scott Boyd ,  George M. Shaw ,  Beatrice H. Hahn ,  Thomas B. Kepler ,  Bette T. Korber ,  Peter Kwong ,  John R. Mascola

IPC: A61K39/21 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

公开(公告)号：US10322141B2

公开(公告)日：2019-06-18

申请号：US15300051

申请日：2015-03-31

Applicant: Duke University ,  The Trustees of The University of Pennsylvania ,  Triad National Security, LLC

Inventor： Barton F. Haynes ,  Beatrice H. Hahn ,  George M. Shaw ,  Bette T. Korber ,  Peter T. Hraber

IPC: A61K39/12 ,  A61K39/21 ,  C07K14/00 ,  C07K14/08 ,  C07K14/15 ,  A61K31/7088 ,  C07K14/155 ,  A61K39/00

Abstract: In certain aspects the invention provides immunogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.