Methods and apparatus for synchronizing data transfers across clock domains for using heads-up indications. An integrated circuit includes a first-in first-out buffer (FIFO); a memory controller configured to operate in a first clock domain and coupled to the FIFO, the first clock domain associated with a first clock signal; a data fabric configured to operate in a second clock domain and coupled to the FIFO, the second clock domain associated with a second clock signal, a second frequency of the second clock signal being different from a first frequency of the first clock signal; and a controller coupled to the FIFO. In some instances, the controller determines a phase relationship between the first clock signal and the second clock signal; monitors one or more first clock edges of the first clock signal and one or more second clock edges of the second clock signal; and sends a first heads-up signal to the memory controller.