Invention Application
- Patent Title: DOUBLE NEGATIVE T CELLS AND PD-1 BLOCKADE FOR THE TREATMENT OF CANCER
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Application No.: US16536948Application Date: 2019-08-09
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Publication No.: US20200046768A1Publication Date: 2020-02-13
- Inventor: Li Zhang , Dalam Ly , Linan Fang
- Applicant: University Health Network
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K16/28 ; A61P35/00
Abstract:
Methods for the treatment of cancer using double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor are described. Tumors treated with DNTs and a PD-1 inhibitor exhibited increased DNT cell infiltration and increased cytotoxicity towards non-small cell lung cancer (NSCLC) cells. Also described are compositions and kits comprising DNTs and a PD-1 or PD-L1 inhibitor and their use for the treatment of cancer.
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