公开(公告)号：US20200046768A1

公开(公告)日：2020-02-13

申请号：US16536948

申请日：2019-08-09

Applicant: University Health Network

Inventor： Li Zhang ,  Dalam Ly ,  Linan Fang

IPC: A61K35/17 ,  C07K16/28 ,  A61P35/00

Abstract: Methods for the treatment of cancer using double negative T cells (DNTs) and a PD-1 or PD-L1 inhibitor are described. Tumors treated with DNTs and a PD-1 inhibitor exhibited increased DNT cell infiltration and increased cytotoxicity towards non-small cell lung cancer (NSCLC) cells. Also described are compositions and kits comprising DNTs and a PD-1 or PD-L1 inhibitor and their use for the treatment of cancer.