Some demonstrative embodiments may include apparatus, system and method of scheduling Time Sensitive Networking (TSN) wireless communications. For example, an apparatus may include logic and circuitry configured to cause a wireless communication Access Point (AP) to allocate at least one Time Sensitive Networking (TSN) enabled (TSN-enabled) Target Wakeup Time (TWT) Service Period (SP) based on one or more timing requirements of a TSN schedule of at least one TSN stream for at least one wireless communication station (STA); to transmit a TWT scheduling message to schedule the TSN-enabled TWT SP, the TWT scheduling message including an indication that the TSN-enabled TWT SP is restricted to only TSN communications; and, during the TSN-enabled TWT SP, to communicate one or more frames of the at least one TSN stream with the at least one STA.