Invention Grant
US08372390B2 Recombiant lentivirus comprising an E2 alphavirus glycoprotein that binds to DC-SIGN
有权
重组慢病毒包含与DC-SIGN结合的E2甲病毒糖蛋白
- Patent Title: Recombiant lentivirus comprising an E2 alphavirus glycoprotein that binds to DC-SIGN
- Patent Title (中): 重组慢病毒包含与DC-SIGN结合的E2甲病毒糖蛋白
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Application No.: US12688779Application Date: 2010-01-15
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Publication No.: US08372390B2Publication Date: 2013-02-12
- Inventor: Pin Wang , Lili Yang , David Baltimore
- Applicant: Pin Wang , Lili Yang , David Baltimore
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K48/00
Abstract:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
Public/Granted literature
- US20100120140A1 TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION Public/Granted day:2010-05-13
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