Invention Grant
- Patent Title: Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
- Patent Title (中): 与用于肿瘤靶向成像化合物缀合的氨基酸连接基团的合成和组成
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Application No.: US14207130Application Date: 2014-03-12
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Publication No.: US09061057B2Publication Date: 2015-06-23
- Inventor: Sumith A. Kularatne , Sakkarapalayam M. Mahalingam , Philip S. Low
- Applicant: Purdue Research Foundation
- Applicant Address: US IN West Lafayette
- Assignee: Purdue Research Foundation
- Current Assignee: Purdue Research Foundation
- Current Assignee Address: US IN West Lafayette
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; A61K49/00 ; G01N33/569 ; G01N33/566 ; G01N33/50
Abstract:
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
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