公开(公告)号：US12053532B2

公开(公告)日：2024-08-06

申请号：US17114195

申请日：2020-12-07

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low ,  Mohammad Noshi

IPC: A61K51/00 ,  A61B5/00 ,  A61K49/00 ,  A61M36/14 ,  G01N33/574 ,  G01N33/58

CPC classification number: A61K49/0052 ,  A61B5/0071 ,  A61K49/0032 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/57449 ,  G01N33/582

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20220016630A1

公开(公告)日：2022-01-20

申请号：US17390404

申请日：2021-07-30

Applicant: Purdue Research Foundation

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

IPC: B01L3/00 ,  G01N33/574 ,  G01N33/543 ,  G01N27/74

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

公开(公告)号：US20200155696A1

公开(公告)日：2020-05-21

申请号：US16749827

申请日：2020-01-22

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/08 ,  A61K49/00 ,  A61K31/475 ,  A61K31/4745 ,  A61K31/426 ,  C07K5/08 ,  A61K51/04 ,  C07D207/416 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180303950A1

公开(公告)日：2018-10-25

申请号：US15997451

申请日：2018-06-04

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  C07C323/52 ,  A61K51/04 ,  A61K47/54 ,  A61K49/00 ,  A61K31/475 ,  A61K51/08 ,  C07K5/08 ,  A61K31/426 ,  A61K31/4745 ,  C07D207/416

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10046054B2

公开(公告)日：2018-08-14

申请号：US14794482

申请日：2015-11-23

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/54 ,  A61K31/426 ,  C07C323/52 ,  A61K47/48 ,  C07D207/416 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

CPC classification number: A61K47/64 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180147286A1

公开(公告)日：2018-05-31

申请号：US15578226

申请日：2016-05-29

Applicant: Jindrich Kopecek ,  Jiyan Yang ,  Purdue Research Foundation Office of Technology Commercialization ,  University of Utah Research Foundation

Inventor： Stewart Andrew Low ,  Philip S. Low ,  Christopher Galliford ,  Jindrich Kopecek ,  Jiyan Yang

IPC: A61K47/42 ,  A61M5/00 ,  A61P19/00 ,  A61K9/107 ,  A61K31/404

CPC classification number: A61K47/42 ,  A61K9/1075 ,  A61K31/404 ,  A61L27/22 ,  A61L27/227 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/02 ,  A61M5/002 ,  A61P19/00 ,  C07K7/06 ,  C07K7/08

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

公开(公告)号：US20170136462A1

公开(公告)日：2017-05-18

申请号：US15343908

申请日：2016-11-04

Applicant: Purdue Research Foundation

Inventor： Cagri Abdullah Savran ,  Philip S. Low ,  Chun-Li Chang

IPC: B01L3/00 ,  G01N33/574 ,  G01N27/74 ,  G01N33/543

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

公开(公告)号：US20140271482A1

公开(公告)日：2014-09-18

申请号：US14010098

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam

IPC: A61K49/00 ,  G01N33/50

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US08808998B2

公开(公告)日：2014-08-19

申请号：US13714659

申请日：2012-12-14

Applicant: Purdue Research Foundation

Inventor： Philip S. Low

IPC: G01N33/53

CPC classification number: A61K49/0043 ,  A61K49/0041 ,  A61K49/0052 ,  A61K49/006 ,  A61K51/0474 ,  A61K51/0497 ,  G01N33/5061 ,  G01N33/92 ,  G01N2800/323

Abstract: The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.

Abstract translation: 本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。 该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞 使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置或通过使用外部成像技术检测由发色团发出的光来识别活性斑块。 本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

公开(公告)号：US11504357B2

公开(公告)日：2022-11-22

申请号：US16869268

申请日：2020-05-07

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64 ,  A61K31/426 ,  C07C323/52 ,  A61K51/04

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.