A method of detecting constituents in a sample includes generating a plurality of ions in an ionization region. The method also includes preventing the plurality of ions in the ionization region from flowing into a drift region through inducing a first voltage in a device positioned between the two regions. The method further includes injecting at least a portion of the ions from the ionization region into the drift region. The method also includes regulating the voltage in the device to a second voltage for a first predetermined temporal period, the second voltage less than the first voltage. The method further includes regulating the voltage in the device to the first voltage. The method also includes regulating the voltage in the device to the second voltage for a second predetermined temporal period, the second predetermined temporal period different from the first predetermined temporal period.