The invention relates to the technical field of wireless communication, and provides a method for joint optimization of schedule and resource allocation based on a genetic algorithm, which is applied in a CoMP communication system. The method includes steps of: S1, encoding chromosome; S2, initializing setting; S3, computing fitness value; S4, determining whether the optimal solution is better than an elite: if yes, updating the elite and executing S5, and if no, turning to S5; S5, determining whether a predetermined generation of population has been generated or not, if no, executing S6, otherwise, turning to S8; S6, participating reproduction process to generate two offspring chromosome individuals; S7, determining whether a predetermined number of offspring chromosome individuals have been generated, if yes, turning to S3 to compute again; otherwise keeping on reproduction; S8, performing schedule and resource allocation according to a solution corresponding to the elite. Under the condition of satisfying schedule limitation and power limitation, the method can, by uniting schedule and resource allocation, efficiently optimize system performance with less computing complexity.