Cache lines in a computing environment with transactional memory are configurable with a coherency mode. Cache lines in full-line coherency mode are operated or managed with full-line granularity. Cache lines in sub-line coherency mode are operated or managed as sub-cache line portions of a full cache line. When a transaction accessing a cache line in full-line coherency mode results in a transactional abort, the cache line may be placed in sub-line coherency mode if the cache line is a high-conflict cache line. The cache line may be associated with a counter in a conflict address detection table that is incremented whenever a transaction conflict is detected for the cache line. The cache line may be a high-conflict cache line when the counter satisfies a high-conflict criterion, such as reaching a threshold value. The cache line may be returned to full-line coherency mode when a reset criterion is satisfied.