Invention Grant
- Patent Title: Chromatography apparatus having diffusion-bonded and surface-modified components
- Patent Title (中): 色谱装置具有扩散键合和表面改性的组分
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Application No.: US13637273Application Date: 2011-03-25
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Publication No.: US09409252B2Publication Date: 2016-08-09
- Inventor: Bernard Bunner , Theodore A. Dourdeville
- Applicant: Bernard Bunner , Theodore A. Dourdeville
- Applicant Address: US MA Milford
- Assignee: WATERS TECHNOLOGIES CORPORATION
- Current Assignee: WATERS TECHNOLOGIES CORPORATION
- Current Assignee Address: US MA Milford
- Agency: McCarter & English, LLP
- Agent Deborah M. Vernon
- International Application: PCT/US2011/029934 WO 20110325
- International Announcement: WO2011/119922 WO 20110929
- Main IPC: B23K20/02
- IPC: B23K20/02 ; B01L3/00 ; B23K20/233 ; G01N30/60 ; H01J49/00 ; H01J49/16 ; B23K101/18 ; B23K103/14 ; G01N30/72
Abstract:
A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
Public/Granted literature
- US20130014567A1 CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS Public/Granted day:2013-01-17
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