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    DUAL MODE SAMPLE MANAGER
    1.
    发明申请
    DUAL MODE SAMPLE MANAGER 审中-公开

    公开(公告)号：US20200309743A1

    公开(公告)日：2020-10-01

    申请号：US16826667

    申请日：2020-03-23

    Applicant: Waters Technologies Corporation

    Inventor： Sylvain Gilles Cormier ,  Joseph D. Michienzi

    IPC: G01N30/20 ,  G01N30/38 ,  G01N30/32

    Abstract: Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

    METHODOLOGY FOR SCALING METHODS BETWEEN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS
    3.
    发明申请
    METHODOLOGY FOR SCALING METHODS BETWEEN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS 审中-公开
    超临界流体色谱系统之间缩放方法的方法

    公开(公告)号：US20160136544A1

    公开(公告)日：2016-05-19

    申请号：US14898014

    申请日：2014-06-12

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Christopher Hudalla

    IPC: B01D15/40 ,  G01N30/32 ,  B01D15/16

    CPC classification number: B01D15/40 ,  B01D15/16 ,  B01D15/163 ,  B01J3/02 ,  G01N30/32 ,  G01N30/8658 ,  G01N2030/326

    Abstract: A methodology scales supercritical fluid chromatography (SFC) and/or carbon dioxide based chromatography methods between different system and/or column configurations. The methodology includes measuring an average mobile phase density during a first separation utilizing CO2 as a mo bile phase component and substantially duplicating the average density profile for a second separation. Substantial duplication of the average mobile phase density (e.g., within about 10%, 5%, 2.5%, 1%, 0.5%, 0.1 %, 0.05%) results in chromatography for both system and/or column configurations having similar selectivity and retention factors. Average mobile phase density may be, either measured directly, calculated, or approximated using average pressure or density measurements. The average pressure profile may be used as a close approximation to duplicate average density profiles between separations.

    Abstract translation: A方法在不同系统和/或柱构型之间进行超临界流体色谱（SFC）和/或基于二氧化碳的色谱法的比较。 该方法包括在利用CO 2作为微量相分量的第一分离期间测量平均流动相密度，并基本上复制用于第二分离的平均密度分布。 平均流动相密度的显着重复（例如，在约10％，5％，2.5％，1％，0.5％，0.1％，0.05％之内）导致具有相似选择性和保留性的系统和/或柱构型的色谱法 因素 可以使用平均压力或密度测量直接测量，计算或近似平均流动相密度。 平均压力分布可以用于近似分离之间的重复平均密度分布。

    Techniques for mass spectrometry peak list computation using parallel processing
    7.
    发明授权
    Techniques for mass spectrometry peak list computation using parallel processing 有权

    公开(公告)号：US12243731B2

    公开(公告)日：2025-03-04

    申请号：US17682391

    申请日：2022-02-28

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Jose De Corral

    IPC: H01J49/00 ,  G01N30/86 ,  G06F17/00 ,  G01N30/72 ,  G01N30/88

    Abstract: Described are techniques for processing data. Sample analysis is performed generating scans of data. Each scan comprises a set of data elements each associating an ion intensity count with a plurality of dimensions including a retention time dimension and a mass to charge ratio dimension. The scans are analyzed to identify one or more ion peaks. Analyzing includes filtering a first plurality of the scans producing a first plurality of filtered output scans. The filtering including first filtering producing a first filtering output, wherein the first filtering includes executing a plurality of threads in parallel which apply a first filter to the first plurality of scans to produce the first filtering output. Each of the plurality of threads computes at least one filtered output point for at least one corresponding input point included in the plurality of scans. Analyzing includes detecting one or more peaks using the filtered output scans.

    Establishing fluidic connections between chromatography components
    8.
    发明授权
    Establishing fluidic connections between chromatography components 有权

    公开(公告)号：US12222339B2

    公开(公告)日：2025-02-11

    申请号：US18491132

    申请日：2023-10-20

    Applicant: Waters Technologies Corporation

    Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

    IPC: G01N30/60

    Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

    Chromatography column positioning assemblies
    9.
    发明授权
    Chromatography column positioning assemblies 有权

    公开(公告)号：US12181453B2

    公开(公告)日：2024-12-31

    申请号：US17512864

    申请日：2021-10-28

    Applicant: Waters Technologies Corporation

    Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

    IPC: G01N30/60 ,  B01D15/22 ,  G01N30/46

    Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

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