Invention Grant
- Patent Title: Methods for mass spectrometry of mixtures of protein or polypeptides using proton transfer reaction
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Application No.: US15327128Application Date: 2015-07-17
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Publication No.: US09837255B2Publication Date: 2017-12-05
- Inventor: James L. Stephenson, Jr. , John E. P. Syka , August A. Specht
- Applicant: Thermo Finnigan LLC
- Applicant Address: US CA San Jose
- Assignee: Thermo Finnigan LLC
- Current Assignee: Thermo Finnigan LLC
- Current Assignee Address: US CA San Jose
- Agent Thomas F. Cooney
- International Application: PCT/US2015/040914 WO 20150717
- International Announcement: WO2016/011355 WO 20160121
- Main IPC: H01J49/26
- IPC: H01J49/26 ; H01J49/00 ; H01J49/04 ; G01N33/68 ; C12Q1/04
Abstract:
Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.
Public/Granted literature
- US20170162372A1 Methods for Mass Spectrometry of Mixtures of Protein or Polypeptides Using Proton Transfer Reaction Public/Granted day:2017-06-08
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