The present invention discloses a plasma non-stick pan and manufacturing method thereof. The plasma non-stick pan comprises a pan body and a non-stick layer applied to the pan body; a plasma layer is provided between the non-stick layer and the pan body, and the plasma layer comprises a MCrALY layer sprayed to the surface of the pan body and a mixture layer sprayed outside of the MCrALY layer, and the mixture layer is composed of MCrALY particles and metal oxide particles. The MCrALY layer has good toughness and strong adhesion, and it is easy to bind with the substrate with high fastness after binding, playing a buffering role and laying a foundation for the subsequent spraying of mixture layer.