公开(公告)号：EP0808153A1

公开(公告)日：1997-11-26

申请号：EP96906348.0

申请日：1996-02-08

Applicant: MEDTRONIC, INC. ,  Nelson, Timothy S. ,  Bergan, Matthew A.

Inventor： NELSON, Timothy, S. ,  BERGAN, Matthew, A.

IPC: A61K9

CPC classification number: A61K9/0085

Abstract: A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

公开(公告)号：AU4975996A

公开(公告)日：1996-08-27

申请号：AU4975996

申请日：1996-02-08

Applicant: BERGAN MATTHEW A ,  MEDTRONIC INC ,  NELSON TIMOTHY S

Inventor： NELSON TIMOTHY S ,  BERGAN MATTHEW A

IPC: A61K9/00 ,  A61K9/22

Abstract: A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

公开(公告)号：WO2007027289A1

公开(公告)日：2007-03-08

申请号：PCT/US2006/025525

申请日：2006-06-28

Applicant: MEDTRONIC, INC. ,  LYU, Suping ,  FERNANDES, Brian ,  BERGAN, Matthew, A.

Inventor： LYU, Suping ,  FERNANDES, Brian ,  BERGAN, Matthew, A.

IPC: C12N5/06

CPC classification number: A61K9/0019 ,  A61K47/32 ,  C12N5/0658

Abstract: Cell delivery compositions including shear thinning polymers and their use in cell delivery are described. The cell delivery compositions include shear thinning polymers that confer higher viscosity when at rest and decreased viscosity when subject to shear stress when dissolved or suspended in a carrier liquid. These shear thinning properties can facilitate cell delivery. Shear thinning polymer solutions may be used to deliver cells to particular tissue sites in a subject.

Abstract translation: 描述了包含剪切稀化聚合物的细胞递送组合物及其在细胞递送中的用途。 细胞递送组合物包括剪切稀化聚合物，其在静止时赋予较高的粘度，当溶解或悬浮在载体液体中时受剪切应力时粘度降低。 这些剪切稀化性质可以促进细胞递送。 剪切稀化聚合物溶液可用于将细胞递送至受试者中的特定组织部位。

公开(公告)号：WO2010019530A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053340

申请日：2009-08-11

Applicant: MEDTRONIC, INC. ,  WU, Paul, Hsien-fu ,  TAYLOR, Catherine, E. ,  LI, Jianwei ,  BARTLETT, Terese, A. ,  BERGAN, Matthew, A. ,  CHERUIYOT, Linnus

Inventor： WU, Paul, Hsien-fu ,  TAYLOR, Catherine, E. ,  LI, Jianwei ,  BARTLETT, Terese, A. ,  CHERUIYOT, Linnus

IPC: C07F7/18 ,  C08K5/00 ,  C08K5/5419 ,  C08K5/05 ,  C08K5/06 ,  A61L31/16

CPC classification number: A61L27/54 ,  A61K31/575 ,  A61K31/695 ,  A61K47/6957 ,  A61L27/443 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  C07F7/1852

Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.

Abstract translation: 抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。 可以使用几乎任何可水解的离去基团。 除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

公开(公告)号：WO2007019055A3

公开(公告)日：2007-12-06

申请号：PCT/US2006028900

申请日：2006-07-26

Applicant: MEDTRONIC INC ,  MORRIS MARY M ,  BERGAN MATTHEW A ,  FERNADES BRIAN C A ,  GARDESKI KENNETH C ,  SPEAR STANTEN C

Inventor： MORRIS MARY M ,  BERGAN MATTHEW A ,  FERNADES BRIAN C A ,  GARDESKI KENNETH C ,  SPEAR STANTEN C

IPC: A61L27/38 ,  C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/50 ,  C12N5/08

CPC classification number: A61L27/50 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/38 ,  A61L27/3895

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid

Abstract translation: 一种方法包括选择用于植入哺乳动物的细胞类型，并确定细胞类型的比重或密度。 然后，选择比重或密度在与选择的电池类型的比重或密度近似匹配的比重或密度的范围内的载体液体。 还提供了用于将生长细胞递送至哺乳动物组织的液体，其中载体流体组分的密度与由载体流体一致递送的细胞的密度相匹配

公开(公告)号：WO1996024330A1

公开(公告)日：1996-08-15

申请号：PCT/US1996001753

申请日：1996-02-08

Applicant: MEDTRONIC, INC. ,  NELSON, Timothy, S. ,  BERGAN, Matthew, A.

Inventor： MEDTRONIC, INC.

IPC: A61K09/00

CPC classification number: A61K9/0085

Abstract: A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

Abstract translation: 公开了用于连续施用对生物体的神经轴线的止痛剂的装置和方法。 该装置包括装载有止痛剂的聚合物基体。 身体植入神经轴，其中止痛剂扩散到神经元。

公开(公告)号：WO2007019055A2

公开(公告)日：2007-02-15

申请号：PCT/US2006/028900

申请日：2006-07-26

Applicant: MEDTRONIC, INC. ,  MORRIS, Mary, M. ,  BERGAN, Matthew, A. ,  FERNADES, Brian, C.A. ,  GARDESKI, Kenneth, C. ,  SPEAR, Stanten, C.

Inventor： MORRIS, Mary, M. ,  BERGAN, Matthew, A. ,  FERNADES, Brian, C.A. ,  GARDESKI, Kenneth, C. ,  SPEAR, Stanten, C.

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

CPC classification number: A61L27/50 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/38 ,  A61L27/3895

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid

Abstract translation: 一种方法涉及选择用于植入哺乳动物中的细胞类型并识别细胞类型的比重或密度。 然后，选择比重或密度在比重或密度范围内的载体液体，所述比重或密度的范围与所选择的细胞类型的比重或密度近似匹配。 还提供了用于将生长细胞递送到哺乳动物组织中的液体，其中载体流体组分的密度与通过载体流体一贯递送的细胞的密度相匹配<！ - SIPO