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1.发明申请TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开将电刺激神经组织用于放置医用导线的技术
公开(公告)号：WO2009135089A8
公开(公告)日：2009-12-23
申请号：PCT/US2009042447
申请日：2009-04-30
Applicant: MEDTRONIC INC , BURNES JOHN E , GARDESKI KENNETH C , KLEPFER RUTH N , MACAULAY PATRICK E , MORRIS MARY M , SCHEINER AVRAM
Inventor： BURNES JOHN E , GARDESKI KENNETH C , KLEPFER RUTH N , MACAULAY PATRICK E , MORRIS MARY M , SCHEINER AVRAM
CPC classification number: A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. It discloses a system for implantation of a medical lead configured to deliver electrical stimulation to nerve tissue located adjacent a blood vessel, the system comprising: a catheter adapted to be positioned within a lumen of the blood vessel adjacent the nerve tissue; a deployment member extendable and retractable from the catheter through a wall of the blood vessel lumen; and an electrode connected to the deployment member such that the deployment member positions the electrode outside of the blood vessel proximate the nerve tissue when the deployment member is extended through the lumen wall.
Abstract translation: 本公开涉及用于布置医疗引线和电刺激和/或感测电极接近患者体内的神经组织的额外的，内部的和血管内的医学引线放置技术。 其公开了一种用于植入医疗引线的系统，该系统被配置为将电刺激递送至位于血管附近的神经组织，所述系统包括：适于定位在邻近神经组织的血管腔内的导管; 展开构件，所述展开构件可从所述导管延伸并且可缩回穿过所述血管腔的壁; 以及连接到展开部件的电极，使得当展开部件延伸穿过腔壁时，展开部件将电极定位在靠近神经组织的血管外部。
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公开(公告)号：WO2008070769A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/086629
申请日：2007-12-06
Applicant: MEDTRONIC, INC. , KEIMEL, Jack , KAEMMERER, William, F. , MORRIS, Mary, M.
Inventor： KEIMEL, Jack , KAEMMERER, William, F. , MORRIS, Mary, M.
CPC classification number: A61M27/006 , A61M25/0102 , A61M25/0108 , A61M2025/0059 , A61M2025/0063 , A61M2025/0293
Abstract: An intrathecal catheter for delivering fluid to, or withdrawing fluid from, the cerebrospinal fluid compartment of a patient, includes a proximal end and a distal portion. The distal portion has an outer diameter of about 1 mm or less, a bending stiffness of about 0.002 pounds per square inch or less, and a distal end. A delivery region is located between the proximal end and the distal end, and a lumen extends from the proximal end to the delivery region. The catheter may further include a coiled structure region to prevent dislodgement of the catheter from a tissue in which the coiled structure is implanted, for example the cisterna magna. The catheter may also include tines to anchor portions of the catheter, for example to a portion of the spinal canal.
Abstract translation: 用于将流体输送到患者的脑脊液腔室或从患者的脑脊液腔室排出流体的鞘内导管包括近端和远端部分。 远侧部分具有约1mm或更小的外径，约0.002磅/平方英寸或更小的弯曲刚度和远端。 输送区域位于近端和远端之间，并且内腔从近端延伸到输送区域。 导管还可以包括螺旋结构区域，以防止导管从其中植入线圈结构的组织例如大水槽移出。 导管还可以包括用于锚定导管的部分的齿，例如到椎管的一部分。
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3.发明申请TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开用于放置用于电刺激神经组织的医用引线的技术
公开(公告)号：WO2009135082A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042438
申请日：2009-04-30
Applicant: MEDTRONIC, INC. , MORRIS, Mary, M. , SCHEINER, Avram , KLEPFER, Ruth, N. , BURNES, John, E.
Inventor： MORRIS, Mary, M. , SCHEINER, Avram , KLEPFER, Ruth, N. , BURNES, John, E.
CPC classification number: A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. It discloses an implantable medical lead system configured to deliver electrical stimulation from within a lumen of a blood vessel within a patient to nerve tissue located adjacent to and outside of the blood vessel, the system comprising: a medical lead arranged within a lumen of the blood vessel; an electrode connected toward a distal end of the lead adjacent the nerve tissue; and an active fixation member connected toward a distal end of the lead adjacent the nerve tissue and configured to anchor the lead to a wall of the blood vessel lumen.
Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 它公开了一种可植入医疗引线系统，其被配置为将电刺激从患者内的血管的腔内递送到位于血管旁边和外侧的神经组织，该系统包括：设置在血液管腔内的医疗引线 船只; 连接到邻近神经组织的引线的远端的电极; 以及主动固定构件，其朝向邻近神经组织的引线的远端连接并且被配置为将引线固定到血管腔的壁。
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公开(公告)号：WO2006060586A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043489
申请日：2005-12-01
Applicant: MEDTRONIC, INC. , MORRIS, Mary, M. , GARDESKI, Kenneth, J. , UJHELYI, Michael, R. , LECKRONE, Michael, E.
CPC classification number: A61B17/3478 , A61B17/00234 , A61B17/3417 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392 , A61M25/0084 , A61M2025/0037
Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver treatment in the pericardial space are disclosed. A steerable instrument is advanced transvenously into the right atrium of the heart, and a distal segment is deflected into the right atrial appendage. A fixation catheter is advanced employing the steerable instrument to affix a distal fixation mechanism to the atrial wall. A distal segment of an elongated medical device, e.g., a therapeutic catheter or an electrical medical lead, is advanced through the fixation catheter lumen, through the atrial wall, and into the pericardial space. The steerable guide catheter is removed, and the elongated medical device is coupled to an implantable medical device subcutaneously implanted in the thoracic region. The fixation catheter may be left in place.
Abstract translation: 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以在心包空间中递送治疗。 一个可操纵的器械被递送到心脏的右心房，远端部分被偏转到右心耳。 使用可操纵的器械来前进固定导管，以将远端固定机构固定在心房壁上。 细长医疗装置（例如治疗性导管或电气医用引线）的远端部分通过固定导管内腔前进通过心房壁并进入心包空间。 可移动的导向导管被移除，并且细长的医疗装置被联接到皮下植入胸部区域的可植入医疗装置。 固定导管可以留在原位。
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公开(公告)号：WO2005106297A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/013764
申请日：2005-04-22
Applicant: MEDTRONIC, INC. , OLSEN, James, M. , MORRIS, Mary, M. , HEGLAND, Michael , BLANCO, Justin, A.
Inventor： OLSEN, James, M. , MORRIS, Mary, M. , HEGLAND, Michael , BLANCO, Justin, A.
IPC: F16K1/40
CPC classification number: A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
Abstract: Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.
Abstract translation: 公开了包括一个或多个限流器的导管系统。 导管系统可以包括两个或更多个输送分支。 输送分支可以使用可包括一个或多个限流器的分支导管连接器连接到供应导管部分。 限流器可以包括位于管腔内的节流体，通道位于限流器主体和内腔内表面之间，通道限制流经管腔的流经限流器。 通道可以由形成在限流器主体中的凹槽和/或内腔的内表面限定。 还公开了通过使流体流过限流器来提供压力释放的方法。
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Patent Agency Ranking
公开(公告)号：WO2005042068A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/034809
申请日：2004-10-21
Applicant: MEDTRONIC, INC. , MORRIS, Mary, M.
Inventor： MORRIS, Mary, M.
IPC: A61M5/00
CPC classification number: A61M5/14276 , A61M5/16859
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7.发明申请
公开(公告)号：WO2007019055A3
公开(公告)日：2007-12-06
申请号：PCT/US2006028900
申请日：2006-07-26
Applicant: MEDTRONIC INC , MORRIS MARY M , BERGAN MATTHEW A , FERNADES BRIAN C A , GARDESKI KENNETH C , SPEAR STANTEN C
Inventor： MORRIS MARY M , BERGAN MATTHEW A , FERNADES BRIAN C A , GARDESKI KENNETH C , SPEAR STANTEN C
CPC classification number: A61L27/50 , A61K49/0452 , A61K51/1203 , A61L27/38 , A61L27/3895
Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid
Abstract translation: 一种方法包括选择用于植入哺乳动物的细胞类型，并确定细胞类型的比重或密度。 然后，选择比重或密度在与选择的电池类型的比重或密度近似匹配的比重或密度的范围内的载体液体。 还提供了用于将生长细胞递送至哺乳动物组织的液体，其中载体流体组分的密度与由载体流体一致递送的细胞的密度相匹配
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8.发明申请
公开(公告)号：WO2006060514A9
公开(公告)日：2006-07-20
申请号：PCT/US2005043374
申请日：2005-11-30
Applicant: MEDTRONIC INC , SIGG DANIEL C , UJHELYI MICHAEL R , MORRIS MARY M
Inventor： SIGG DANIEL C , UJHELYI MICHAEL R , MORRIS MARY M
CPC classification number: A61M5/14276 , A61B17/00234 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392 , A61M5/1723 , A61M2005/1405 , A61M2205/3523
Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
Abstract translation: 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以向心脏递送药理学特别是NO供体药物。 输注导管的近端连接器联接到输注泵，并且具有远端输注导管腔端部开口的远侧导管段设置在心包空间中。 可植入输注泵可与可植入缺血监测器结合操作以监测缺血状态并触发递送或调节药理学剂的周期性递送以最佳地治疗缺血。 患者可以操作患者活化剂，当感觉到缺血症状时患者传递由可植入输液泵接收的信号并触发推注和/或连续输注的传递。
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9.发明申请TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开用于放置用于电刺激神经组织的医用引线的技术
公开(公告)号：WO2009135089A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042447
申请日：2009-04-30
Applicant: MEDTRONIC, INC. , BURNES, John, E. , GARDESKI, Kenneth, C. , KLEPFER, Ruth, N. , MACAULAY, Patrick, E. , MORRIS, Mary, M. , SCHEINER, Avram
Inventor： BURNES, John, E. , GARDESKI, Kenneth, C. , KLEPFER, Ruth, N. , MACAULAY, Patrick, E. , MORRIS, Mary, M. , SCHEINER, Avram
CPC classification number: A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. It discloses a system for implantation of a medical lead configured to deliver electrical stimulation to nerve tissue located adjacent a blood vessel, the system comprising: a catheter adapted to be positioned within a lumen of the blood vessel adjacent the nerve tissue; a deployment member extendable and retractable from the catheter through a wall of the blood vessel lumen; and an electrode connected to the deployment member such that the deployment member positions the electrode outside of the blood vessel proximate the nerve tissue when the deployment member is extended through the lumen wall.
Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 它公开了用于植入医疗引线的系统，其被配置为将电刺激递送到位于血管附近的神经组织，所述系统包括：适于定位在与神经组织相邻的血管的腔内的导管; 展开构件，其从所述导管延伸并且可从所述血管内腔的壁延伸; 以及连接到所述展开构件的电极，使得当所述展开构件延伸穿过所述管腔壁时，所述展开构件将所述电极定位在靠近所述神经组织的血管外部。
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10.发明申请TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开用于放置用于电刺激神经组织的医用引线的技术
公开(公告)号：WO2009135075A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042427
申请日：2009-04-30
Applicant: MEDTRONIC, INC. , BURNES, John, E. , MORRIS, Mary, M. , BONNER, Matthew, David , HILL, Michael, R.s. , SCHEINER, Avram , KLEPFER, Ruth, N.
Inventor： BURNES, John, E. , MORRIS, Mary, M. , BONNER, Matthew, David , HILL, Michael, R.s. , SCHEINER, Avram , KLEPFER, Ruth, N.
CPC classification number: A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. It discloses an implantable medical lead system configured to deliver electrical stimulation to nerve tissue within a patient, the system comprising: an implantable medical lead comprising a distal portion configured for introduction into a sheath of tissue that contains the nerve tissue; an electrode electrically connected to the distal portion of the implantable medical lead; and an anchor connected to the medical lead and proximally offset from the electrode at least partially outside of the sheath to stabilize placement of the distal portion of the lead within the sheath.
Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 其公开了一种被配置为向患者内的神经组织递送电刺激的可植入医疗引线系统，所述系统包括：可植入医疗引线，其包括构造成引入到包含所述神经组织的组织鞘中的远端部分; 电连接到所述可植入医疗引线的远端部分的电极; 以及锚固件，其连接到医疗引线并且至少部分地至少部分地位于护套的外侧并从电极向近侧偏移，以稳定引线的远侧部分在护套内的放置。
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