公开(公告)号：WO2009135089A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042447

申请日：2009-04-30

Applicant: MEDTRONIC, INC. ,  BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

Inventor： BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

IPC: A61N1/05 ,  A61M25/06

CPC classification number: A61N1/36053 ,  A61M25/09 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/36085 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36128

Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. It discloses a system for implantation of a medical lead configured to deliver electrical stimulation to nerve tissue located adjacent a blood vessel, the system comprising: a catheter adapted to be positioned within a lumen of the blood vessel adjacent the nerve tissue; a deployment member extendable and retractable from the catheter through a wall of the blood vessel lumen; and an electrode connected to the deployment member such that the deployment member positions the electrode outside of the blood vessel proximate the nerve tissue when the deployment member is extended through the lumen wall.

Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 它公开了用于植入医疗引线的系统，其被配置为将电刺激递送到位于血管附近的神经组织，所述系统包括：适于定位在与神经组织相邻的血管的腔内的导管; 展开构件，其从所述导管延伸并且可从所述血管内腔的壁延伸; 以及连接到所述展开构件的电极，使得当所述展开构件延伸穿过所述管腔壁时，所述展开构件将所述电极定位在靠近所述神经组织的血管外部。

公开(公告)号：WO2010080304A1

公开(公告)日：2010-07-15

申请号：PCT/US2009/067244

申请日：2009-12-09

Applicant: MEDTRONIC, INC. ,  GARDESKI, Kenneth C. ,  SHAH, Sonar

Inventor： GARDESKI, Kenneth C. ,  SHAH, Sonar

IPC: A61B19/00

CPC classification number: A61B34/20 ,  A61B2034/2051

Abstract: A navigation element for delivery of a therapy delivery system and method of enabling navigation of a therapy delivery system. The navigation element for a therapy delivery system comprises a flexible elongate tubular sheath having a lumen extending longitudinally therethrough, the lumen of the tubular body being sized to fit over a catheter; and an electromagnetic receiver assembly within the tubular body, the receiver assembly comprising a receiver coil and a conductor coupled to the receiver coil, the conductor coupled to the receiver coil and extending towards a proximal end of the tubular sheath.

Abstract translation: 用于递送治疗递送系统的导航元件和能够导航治疗递送系统的方法。 用于治疗递送系统的导航元件包括具有纵向延伸通过其延伸的内腔的柔性细长管状护套，所述管状体的内腔的尺寸适于配合在导管上; 以及在所述管状主体内的电磁接收器组件，所述接收器组件包括接收器线圈和耦合到所述接收器线圈的导体，所述导体耦合到所述接收器线圈并且朝向所述管状护套的近端延伸。

公开(公告)号：WO2009152486A1

公开(公告)日：2009-12-17

申请号：PCT/US2009/047299

申请日：2009-06-15

Applicant: MEDTRONIC, INC. ,  NEIDERT, Michael R. ,  GARDESKI, Kenneth C. ,  VIDAL, Claude A. ,  REDMOND, Russell J. ,  VERARD, Laurent

Inventor： NEIDERT, Michael R. ,  GARDESKI, Kenneth C. ,  VIDAL, Claude A. ,  REDMOND, Russell J. ,  VERARD, Laurent

IPC: A61B5/06 ,  A61B19/00 ,  G01V15/00

CPC classification number: A61B5/06 ,  A61B5/063 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/0811

Abstract: A medical instrument assembly is disclosed. The medical instrument has proximal and distal ends. A receiver coil being mounted proximate to a distal end of the medical instrument, the receiver coil being electrically connectable at a proximal end of the medical instrument. A deployable object being disposed and movable within the medical instrument. The deployable object bearing a high magnetic permeability material located proximate to the receiver coil. The high magnetic permeability material and the receiver coil combining to form an inductive element having an inductance that varies in a predetermined manner with the position of the deployable device relative to the receiver coil. A determination of the inductance being performed at the proximal end of the delivery catheter indicates the extension of the deployable device through the medical instrument.

Abstract translation: 公开了一种医疗器械组件。 医疗器械具有近端和远端。 接收器线圈安装在医疗器械的远端附近，接收器线圈可在医疗器械的近端电连接。 可部署的物体被布置并在医疗器械内可移动。 承载位于靠近接收器线圈的高磁导率材料的可部署物体。 高磁导率材料和接收器线圈组合以形成具有以预定方式变化的电感的电感元件与可展开装置相对于接收器线圈的位置。 在输送导管的近端执行的电感的确定指示可展开装置通过医疗器械的延伸。

公开(公告)号：WO2007019055A3

公开(公告)日：2007-12-06

申请号：PCT/US2006028900

申请日：2006-07-26

Applicant: MEDTRONIC INC ,  MORRIS MARY M ,  BERGAN MATTHEW A ,  FERNADES BRIAN C A ,  GARDESKI KENNETH C ,  SPEAR STANTEN C

Inventor： MORRIS MARY M ,  BERGAN MATTHEW A ,  FERNADES BRIAN C A ,  GARDESKI KENNETH C ,  SPEAR STANTEN C

IPC: A61L27/38 ,  C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/50 ,  C12N5/08

CPC classification number: A61L27/50 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/38 ,  A61L27/3895

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid

Abstract translation: 一种方法包括选择用于植入哺乳动物的细胞类型，并确定细胞类型的比重或密度。 然后，选择比重或密度在与选择的电池类型的比重或密度近似匹配的比重或密度的范围内的载体液体。 还提供了用于将生长细胞递送至哺乳动物组织的液体，其中载体流体组分的密度与由载体流体一致递送的细胞的密度相匹配

公开(公告)号：WO2010014420A1

公开(公告)日：2010-02-04

申请号：PCT/US2009/050795

申请日：2009-07-16

Applicant: MEDTRONIC, INC. ,  NEIDERT, Michael, R. ,  GARDESKI, Kenneth, C. ,  CANFIELD, Monte, R.

Inventor： NEIDERT, Michael, R. ,  GARDESKI, Kenneth, C. ,  CANFIELD, Monte, R.

IPC: A61B19/00

CPC classification number: A61B34/20 ,  A61B5/0066 ,  A61B5/036 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/4839 ,  A61B5/7285 ,  A61B6/032 ,  A61B6/037 ,  A61B6/5247 ,  A61B6/541 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/543 ,  A61B18/1492 ,  A61B2017/00703 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B2090/3735 ,  A61B2090/374 ,  A61B2090/3764 ,  A61B2090/3784 ,  A61M25/0108 ,  A61M25/09 ,  A61M2230/04 ,  A61N1/372

Abstract: An image guided navigation system for navigating a region of a patient which is gated using ECG signals to confirm diastole. The navigation system includes an imaging device, a tracking device, a controller, and a display. The imaging device generates images of the region of a patient. The tracking device tracks the location of the instrument in a region of the patient. The controller superimposes an icon representative of the instrument onto the images generated from the imaging device based upon the location of the instrument. The display displays the image with the superimposed instrument. The images and a registration process may be synchronized to a physiological event.

Abstract translation: 用于导航使用ECG信号门控以确认舒张的患者区域的图像引导导航系统。 导航系统包括成像装置，跟踪装置，控制器和显示器。 成像装置产生患者区域的图像。 跟踪装置跟踪在患者的区域中的仪器的位置。 基于仪器的位置，控制器将表示仪器的图标叠加到从成像装置产生的图像上。 显示屏用叠加的乐器显示图像。 图像和注册过程可以与生理事件同步。

公开(公告)号：WO2009129360A1

公开(公告)日：2009-10-22

申请号：PCT/US2009/040746

申请日：2009-04-16

Applicant: MEDTRONIC, INC. ,  NEIDERT, Michael, R. ,  GARDESKI, Kenneth, C.

Inventor： NEIDERT, Michael, R. ,  GARDESKI, Kenneth, C.

IPC: A61M25/00

CPC classification number: A61M25/0021 ,  A61M25/0023

Abstract: A delivery device includes an outer sidewall and an inner sidewall extending therein. An outer surface of the inner sidewall defines a plurality of longitudinally extending grooves, each of which interlock with a corresponding inward protruding member of a plurality of longitudinally extending inward protruding members defined by an inner surface of the outer sidewall. A longitudinally extending lumen of the device, which may accommodate delivery of an implantable medical device, is defined, at least in part, by the inner surface of the inner sidewall. A slitting zone of the device, for example, provided by one of the sidewalls extending less than 360 degrees about a longitudinal axis of the device, enables removal of the delivery device from around the delivered device.

Abstract translation: 输送装置包括外侧壁和在其中延伸的内侧壁。 内侧壁的外表面限定多个纵向延伸的槽，每个槽与由外侧壁的内表面限定的多个纵向延伸的向内突出构件的相应向内突出构件互锁。 至少部分地由内侧壁的内表面限定可容纳可植入医疗装置的输送的装置的纵向延伸的内腔。 例如，由围绕装置的纵向轴线延伸小于360度的侧壁之一提供的装置的切割区域使得能够从输送装置周围移除输送装置。

公开(公告)号：WO2011025708A2

公开(公告)日：2011-03-03

申请号：PCT/US2010/046066

申请日：2010-08-20

Applicant: MEDTRONIC, INC. ,  MARKOWITZ, Toby, H. ,  GARDESKI, Kenneth, C. ,  CARVER, Jean, M. ,  YASGER, Kendra ,  NEIDERT, Michael, R. ,  VERARD, Laurent ,  HARTMANN, Steven, L. ,  BZOSTEK, Andrew ,  JASCOB, Bradley, A.

Inventor： MARKOWITZ, Toby, H. ,  GARDESKI, Kenneth, C. ,  CARVER, Jean, M. ,  YASGER, Kendra ,  NEIDERT, Michael, R. ,  VERARD, Laurent ,  HARTMANN, Steven, L. ,  BZOSTEK, Andrew ,  JASCOB, Bradley, A.

IPC: A61B19/00

CPC classification number: A61B90/13 ,  A61B18/1492 ,  A61B34/20 ,  A61B34/25 ,  A61B2017/00026 ,  A61B2034/2051 ,  A61B2090/0818

Abstract: A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.

公开(公告)号：WO2011008332A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/034834

申请日：2010-05-14

Applicant: MEDTRONIC, INC. ,  BONNER, Matthew ,  GARDESKI, Kenneth C. ,  MEHDIZADEH, Bruce R. ,  CHRISTOPHERSON, Roger ,  NEIDERT, Michael R.

Inventor： BONNER, Matthew ,  GARDESKI, Kenneth C. ,  MEHDIZADEH, Bruce R. ,  CHRISTOPHERSON, Roger ,  NEIDERT, Michael R.

IPC: A61B19/00 ,  A61B17/00 ,  A61M25/02

CPC classification number: A61B5/06 ,  A61B5/0538 ,  A61B5/061 ,  A61B5/062 ,  A61B5/065 ,  A61B5/067 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61M25/0194 ,  A61M25/02 ,  A61M2025/0166 ,  A61M2025/026

Abstract: An apparatus for subcutaneous lead guidance includes a flexible guide strap (130), a navigation catheter (150) and a tunneling tool (110). The guide strap includes an upper layer (134) having a plurality of retainer formations (136) and a substrate (132) attachable on a patient's skin extending between an incision (80) and a target site (84). The navigation catheter is coupled to the upper layer via the retainer formations from a first end (130a) to a second end (130b) of the guide strap. The navigation catheter includes a plurality of position sensors (140) for generating a subcutaneous navigation volume (170) between the incision and the target site when the navigation catheter is coupled to a navigation system (10). The tunneling tool has a distal portion (116) with a leading end (112) and at least one position sensor on the distal portion for viewing digital representation of the distal portion in relation to the navigation volume on a display (36) coupled to the navigation system.

Abstract translation: 用于皮下引导引导的装置包括柔性引导带（130），导航导管（150）和隧道工具（110）。 引导带包括具有多个保持架结构（136）的上层（134）和可在切口（80）和目标部位（84）之间延伸的病人皮肤上的基底（132）。 导航导管经由保持器结构从上层与第二端（130a）连接到导带的第二端（130b）。 导航导管包括多个位置传感器（140），用于当导航导管联接到导航系统（10）时，在切口和目标部位之间产生皮下导航体积（170）。 隧道工具具有远端部分（116），其具有前端（112）和远端部分上的至少一个位置传感器，用于在显示器（36）上相对于导航体积观察远端部分的数字表示，所述显示器（36） 导航系统。

公开(公告)号：WO2009135083A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042439

申请日：2009-04-30

Applicant: MEDTRONIC, INC. ,  BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

Inventor： BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

IPC: A61M25/06 ,  A61B17/34 ,  A61N1/05 ,  A61M25/00

CPC classification number: A61N1/36053 ,  A61M25/09 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/36085 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36128

Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. This disclosure is directed to a system for implantation of an implantable medical lead within a lumen of a blood vessel within a patient for delivery of electrical stimulation to nerve tissue located adjacent to and outside of the blood vessel, the system comprising: a catheter adapted to be positioned within the blood vessel lumen adjacent the nerve tissue; an electrode configured to be advanced toward a wall of the blood vessel lumen; and a sensor configured to detect the relative positions of the nerve tissue outside of the blood vessel and the electrode within the blood vessel lumen.

Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 本公开涉及一种用于在患者体内的血管的腔内植入可植入医疗引线的系统，用于将电刺激递送到位于血管附近和外部的神经组织，所述系统包括：适于 定位在与神经组织相邻的血管腔内; 构造成朝向血管腔的壁前进的电极; 以及传感器，被配置为检测血管外部的神经组织和血管腔内的电极的相对位置。

公开(公告)号：WO2007079352A2

公开(公告)日：2007-07-12

申请号：PCT/US2006/062150

申请日：2006-12-15

Applicant: MEDTRONIC, INC. ,  NEIDENT, Michael, R. ,  GOODE, Johnson, E. ,  SCHNEIDER, Mark, D. ,  GARDESKI, Kenneth, C.

Inventor： NEIDENT, Michael, R. ,  GOODE, Johnson, E. ,  SCHNEIDER, Mark, D. ,  GARDESKI, Kenneth, C.

IPC: A61B17/32 ,  A61B19/00 ,  G01R33/28

CPC classification number: A61B19/5244 ,  A61B5/0084 ,  A61B5/055 ,  A61B5/6852 ,  A61B10/04 ,  A61B17/1214 ,  A61B17/3478 ,  A61B18/1492 ,  A61B18/18 ,  A61B34/20 ,  A61B34/25 ,  A61B90/36 ,  A61B90/39 ,  A61B2018/00071 ,  A61B2018/00839 ,  A61B2034/2051 ,  A61B2090/3958

Abstract: An electromagnetic receiver assembly is included in a navigation element for a therapy delivery system, if the system is modular, the navigation element may he an insert-able module thereof and/or include a lumen to receive another insertable module.

Abstract translation: 如果系统是模块化的，则导航元件可以是其可插入模块和/或包括内腔以接收另一个导管元件，而电磁接收器组件包括在治疗输送系统的导航元件中 可插入模块。