公开(公告)号：WO2010144646A3

公开(公告)日：2010-12-16

申请号：PCT/US2010/038077

申请日：2010-06-10

Applicant: ABBOTT LABORATORIES ,  DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachin V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  SOLTWEDEL, Todd N. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  MARING, Clarence J. ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  ROCKWAY, Todd W. ,  LIU, Dachun ,  PRATT, John K. ,  LAVIN, Michael J. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Seble H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel, D. ,  BELLIZZI, Mary, E.

Inventor： DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachin V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  SOLTWEDEL, Todd N. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  MARING, Clarence J. ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  ROCKWAY, Todd W. ,  LIU, Dachun ,  PRATT, John K. ,  LAVIN, Michael J. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Seble H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel, D. ,  BELLIZZI, Mary, E.

IPC: C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：WO2010075380A1

公开(公告)日：2010-07-01

申请号：PCT/US2009/069188

申请日：2009-12-22

Applicant: ABBOTT LABORATORIES ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  HUTCHINS, Charles, W. ,  KRUEGER, Allan, C. ,  RANDOLPH, John, T. ,  MOTTER, Christopher, E. ,  KRISHNAN, Preethi ,  MISTRY, Neeta, C. ,  PILOT-MATIAS, Tami, J. ,  PATEL, Sachin, V. ,  LI, Xiaoyan ,  SOLTWEDEL, Todd, N. ,  NELSON, Lissa, T.

Inventor： DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  HUTCHINS, Charles, W. ,  KRUEGER, Allan, C. ,  RANDOLPH, John, T. ,  MOTTER, Christopher, E. ,  KRISHNAN, Preethi ,  MISTRY, Neeta, C. ,  PILOT-MATIAS, Tami, J. ,  PATEL, Sachin, V. ,  LI, Xiaoyan ,  SOLTWEDEL, Todd, N. ,  NELSON, Lissa, T.

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/519 ,  A61P31/14

CPC classification number: C07D471/04 ,  C07D239/48

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：WO2010144646A2

公开(公告)日：2010-12-16

申请号：PCT/US2010038077

申请日：2010-06-10

Applicant: ABBOTT LAB ,  DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  SOLTWEDEL TODD N ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  LAVIN MICHAEL J ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  SOLTWEDEL TODD N ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  LAVIN MICHAEL J ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE

IPC: C07D403/14

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010120935A1

公开(公告)日：2010-10-21

申请号：PCT/US2010/031102

申请日：2010-04-14

Applicant: ABBOTT LABORATORIES ,  DEGOEY, David, A. ,  HUTCHINS, Charles, W. ,  KATI, Warren, M. ,  DONNER, Pamela, L. ,  NELSON, Lissa, T. ,  JINKERSON, Tammie, K. ,  KEDDY, Ryan, G. ,  MOTTER, Christopher, E. ,  MATULENKO, Mark, A. ,  KRUEGER, Allan, C. ,  PATEL, Sachin, V. ,  RANDOLPH, John, T. ,  SOLTWEDEL, Todd, N.

Inventor： DEGOEY, David, A. ,  HUTCHINS, Charles, W. ,  KATI, Warren, M. ,  DONNER, Pamela, L. ,  NELSON, Lissa, T. ,  JINKERSON, Tammie, K. ,  KEDDY, Ryan, G. ,  MOTTER, Christopher, E. ,  MATULENKO, Mark, A. ,  KRUEGER, Allan, C. ,  PATEL, Sachin, V. ,  RANDOLPH, John, T. ,  SOLTWEDEL, Todd, N.

IPC: C07D205/02 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/454 ,  A61P29/00

CPC classification number: C07D207/16 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/5377 ,  A61K38/00 ,  C07D205/04 ,  C07D207/22 ,  C07D209/52 ,  C07D211/60 ,  C07D263/06 ,  C07D277/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07K5/06034 ,  C07K5/06043 ,  C07K5/0606 ,  C07K5/06069 ,  C07K5/06078 ,  C07K5/06139

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.