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    ATRIAL PEPTIDE DERIVATIVES
    3.
    发明申请
    ATRIAL PEPTIDE DERIVATIVES 审中-公开
    ATRIAL肽衍生物

    公开(公告)号：WO1990014362A1

    公开(公告)日：1990-11-29

    申请号：PCT/US1990002917

    申请日：1990-05-23

    Applicant: ABBOTT LABORATORIES ,  LUCAS, Scott, D. ,  ROCKWAY, Todd, W. ,  DAVIDSEN, Steven, K. ,  THOMAS, A., Mitchell ,  VON GELDERN, Thomas, W.

    Inventor： ABBOTT LABORATORIES

    IPC: C07K07/08

    CPC classification number: C07K14/58 ,  A61K38/00

    Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

    Abstract translation: 本发明提供了具有有用的低血压，利尿钠，利尿剂，改善释放，肾保护，平滑肌松弛剂和血管舒张活性的新型肽。 本发明的新型心房肽包括式（I）或其药学上可接受的盐，酯或酰胺，其中R 1选自氢，乙酰基氨基，氨基，Arg，Cit，His，Lys，Orn和 丝氨酸 - 丝氨酸; R 2是含硫基团; R 3是疏水性氨基酸或二肽; R 4是二肽间隔物或式X-Y的三肽，其中X是二肽间隔物，Y是碱性氨基酸; R 5是疏水性氨基酸; R 6是多至三个氨基酸的肽; R 7选自Cha，Phe，Cha-Arg，Phe-Arg，（D）Phe-Arg，Phe-（D）Arg，Phe> Arg，Leu-Arg，Ala-Arg，Arg和Gly -翼; R 8为含硫基团。

    ATRIAL PEPTIDE DERIVATIVES
    7.
    发明申请
    ATRIAL PEPTIDE DERIVATIVES 审中-公开
    ATRIAL肽衍生物

    公开(公告)号：WO1989010935A1

    公开(公告)日：1989-11-16

    申请号：PCT/US1989001928

    申请日：1989-05-05

    Applicant: ABBOTT LABORATORIES ,  ROCKWAY, Todd, W. ,  KISO, Yoshiaki ,  DAVIDSEN, Steven, K. ,  LUCAS, Scott, D. ,  THOMAS, A., Mitchell ,  VON GELDERN, Thomas, W.

    Inventor： ABBOTT LABORATORIES

    IPC: C07K07/08

    CPC classification number: C07K14/582 ,  A61K38/00

    Abstract: Atrial peptides comprising the amino acid sequence (I), wherein R1 is hydrogen, Ser, Cit, SerSer, Arg, Carbamoyl Ser, Guanido-Ser-Ser, Amcca, Guanido-Amcca, Lys, ArgArg, Ser-Arg, Ser-Lys, Acetyl-Ser-Ser, D-Ser-Ser, Ser-D-Ser, Guanido-Aocta, Aunda, Aocta, Ahexa, HSer, Apenta, Papaa, Abuta, Mamba, Orn, D-Orn or Acetyl-apenta, Acetyl-Ahexa, Guanido; R2 is Cys, D-Cys or Pen; R3 is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, beta-Ala or Gly; R4 is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA; R5 is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa; R6 is Arg, D-Arg or Cit; R7 is Ile, Leu, D-Leu or Met; R8 is Asp, Asn, beta-methylAsp, cycloAsp, Gly or Ser; R9 is Arg, D-Arg or Ala; R10 is Ile, Leu or Phe; R11 is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline; R12 is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or beta-NA1; R13 is OH, Arg, Arg-NH2, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.

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