公开(公告)号：WO2018191022A1

公开(公告)日：2018-10-18

申请号：PCT/US2018/025052

申请日：2018-03-29

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： KENWORTHY, Michael, W. ,  GANELIN, Boris

IPC: F04D29/22 ,  F04D29/42 ,  F04D29/66

Abstract: An improved rotary machine of the invention may include a rotor 30 with an impeller 20 mounted thereon. A side cavity may be formed between the impeller 20 and the housing 8. The rotary machine may be further equipped with an annular subdividing disk 1 12, 122, 132, 142 for segmenting a fluid flow in the cavity into a first fluid flow between the disc and the impeller 20, and a second fluid flow on the other side of the disk between the disc and the housing 8. The rotary machine of the invention also features a peripheral annular space formed in the periphery of the housing in the cavity at a location adjacent to a peripheral region of the annular subdividing disk 1 12, 122, 132, 142. Importantly, this peripheral annular space is void of restrictions to circumferential fluid flow therein so as to alter the second fluid flow in the cavity in order to reduce pressure variations and flow disturbances along the circumference of the rotary machine. This in turn improves rotational balance of the rotary machine.

公开(公告)号：WO2003079976A3

公开(公告)日：2003-10-02

申请号：PCT/US2003/007827

申请日：2003-03-14

Applicant: TECHNOLOGY COMMERCIALIZATION CORP. ,  KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

Inventor： KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

IPC: A61F13/00

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, especially for patients addicted to opioid-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

公开(公告)号：WO2003079976A2

公开(公告)日：2003-10-02

申请号：PCT/US2003/007827

申请日：2003-03-14

Applicant: TECHNOLOGY COMMERCIALIZATION CORP. ,  KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

Inventor： KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

IPC: A61K

CPC classification number: A61K31/35 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/0073

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, especially for patients addicted to opioid-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

Abstract translation: 具有镇静作用的物质在药学上可接受的载体中包含治疗有效量的γ-吡喃酮，例如科美酸，肉碱酸，螯合酸等。 当以每千克体重患者的5至200mg活性成分的日剂量施用时，该物质可用于治疗各种神经性疾病，例如失眠，焦虑，神经症，抑郁症以及戒断症状 药物成瘾患者，特别是对于以阿片样物质为主的药物上瘾的患者。 该物质可以以多种方式递送，包括口服，胃肠外，透皮和经粘膜给药的药物的全身给药。 对于吸毒成瘾患者，优选的给药方法包括皮下植入物，其在5至30天，优选13至20天的整个治疗期间以有效的每日速率持续释放活性成分。

公开(公告)号：WO2011068831A3

公开(公告)日：2011-10-06

申请号：PCT/US2010058498

申请日：2010-12-01

Applicant: TECHNOLOGY COMMERCIALIZATION CORP

Inventor： GANELIN BORIS ,  KENWORTHY MICHAEL W

IPC: E21B15/02 ,  E21B17/01

CPC classification number: E21B17/203 ,  E21B17/01 ,  F16L11/133 ,  F16L11/22 ,  F16L41/03

Abstract: Disclosed is a tubing system for transporting a gas-liquid flow from a well to a production platform or processing facility. It includes a dual pathway section between the well and the production point having a first tubing portion and a second tubing portion. The second tubing portion includes a plurality of parallel channels so as to divide the multi-phase flow into a plurality of flows through individual channels. This is done to reduce flow slippage of the lower viscosity portion of the flow, which may lead to inefficiencies in flow characteristics, and often, undesirable cyclical variations in pressure and fluid volume. This is especially useful in inclined portions of the petroleum flow pipe system and along hilly terrain. The first round tubing portion is used for transporting the gas-liquid flow as well as for maintenance purposes, such as for pigging, fishing or coiled tubing operations.

Abstract translation: 公开了一种用于将气液流从井输送到生产平台或处理设施的管道系统。 它包括井和生产点之间的双通道部分，其具有第一管部分和第二管部分。 第二管道部分包括多个平行通道，以便将多相流分成通过各个通道的多个流。 这样做是为了减少流动的较低粘度部分的流动滑动，这可能导致流动特性的低效率，并且通常会导致压力和流体体积的不希望的周期性变化。 这在石油管道系统的倾斜部分和丘陵地带尤其有用。 第一圆管部分用于输送气液流动以及用于维护目的，例如用于清管，捕鱼或连续油管作业。

公开(公告)号：WO2011068831A2

公开(公告)日：2011-06-09

申请号：PCT/US2010/058498

申请日：2010-12-01

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： GANELIN, Boris ,  KENWORTHY, Michael, W.

CPC classification number: E21B17/203 ,  E21B17/01 ,  F16L11/133 ,  F16L11/22 ,  F16L41/03

Abstract: Disclosed is a tubing system for transporting a gas-liquid flow from a well to a production platform or processing facility. It includes a dual pathway section between the well and the production point having a first tubing portion and a second tubing portion. The second tubing portion includes a plurality of parallel channels so as to divide the multi-phase flow into a plurality of flows through individual channels. This is done to reduce flow slippage of the lower viscosity portion of the flow, which may lead to inefficiencies in flow characteristics, and often, undesirable cyclical variations in pressure and fluid volume. This is especially useful in inclined portions of the petroleum flow pipe system and along hilly terrain. The first round tubing portion is used for transporting the gas-liquid flow as well as for maintenance purposes, such as for pigging, fishing or coiled tubing operations.

Abstract translation: 公开了一种用于将气体 - 液体流从井输送到生产平台或处理设施的管道系统。 它包括井和生产点之间的双通道部分，其具有第一管部分和第二管部分。 第二管道部分包括多个并行通道，以便将多相流分成多个通过各个通道的流。 这是为了减少流动的较低粘度部分的流动滑移，这可能导致流动特性的低效率，并且通常是压力和流体体积的不期望的周期性变化。 这在石油流管系统的倾斜部分和丘陵地带特别有用。 第一圆管部分用于输送气液流以及用于维护目的，例如用于清管，钓鱼或连续油管操作。

公开(公告)号：WO2008038160A2

公开(公告)日：2008-04-03

申请号：PCT/IB2007/004218

申请日：2007-06-21

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

CPC classification number: A61K31/351

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma- pyrone such as comenic acid, meconic acid, 5-methoxy-gamma-pyrone-2-carboxylic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 0.05 mg to about 10,000 mg of active ingredient per unit dose of a patient, the substance can be used to treat various disorders of a nervous system such as pain, insomnia, anxiety, neurosis, depression, as well as withdrawal symptoms experienced by drug addiction patients, especially for patients addicted to opiate-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

Abstract translation: 具有镇静作用的物质在药学上可接受的载体中包含治疗有效量的γ-吡喃酮，例如康宁酸，麦康酸，5-甲氧基-γ-吡喃酮-2-羧酸。 当以每单位剂量的患者的0.05mg至约10,000mg活性成分的日剂量施用时，该物质可用于治疗神经系统的各种疾病，例如疼痛，失眠，焦虑，神经症，抑郁症，如 以及吸毒成瘾患者的戒断症状，​​特别是对于以鸦片类为主的药物成瘾的患者。 物质可以以多种方式递送，包括口服，胃肠外，透皮和经粘膜给药的药物的全身给药。 对于吸毒成瘾患者，优选的给药方法包括皮下植入物，其在5至30天，优选13至20天的整个治疗期间以有效的每日速率持续释放活性成分。

公开(公告)号：WO2004000038A1

公开(公告)日：2003-12-31

申请号：PCT/US2003/018831

申请日：2003-06-13

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： SOBOL, Constantin, V. ,  SOBOL, Yuzefa, T.

IPC: A23K3/03

CPC classification number: A23C9/133 ,  A23L7/104 ,  A23L19/20 ,  A23L33/135 ,  A23L33/17 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  Y02A50/401 ,  Y02A50/406 ,  Y02A50/471 ,  Y02A50/473

Abstract: A method of producing a hydrolyzed fermented medium containing microorganisms such as bacteria or yeast and the products of their metabolism in high concentration, the method includes providing at least one solid plant product reduced to small pieces and mixed with sugar and a biocompatible liquid such as milk for fermentation at a temperature of between 35 and 58 degrees C until the acidity of the medium reaches the range of 300 to 900 in Terner degrees. In an alternative embodiment, the medium is prepared by mixing in predetermined amounts of sprouted grains, biocompatible liquid inoculated with at least one of a variety of non-pathogenic microorganisms, vegetables, fruits, berries, high protein products, herbs, sugar, and a chemical element such as potassium. The mixture is then fermented at a selected temperature for a specified length of time to reach high acidity and high concentration of products of bacterial metabolism. A liquid phase is separated from a solid sediment phase and can be used to treat a wide variety of diseases including HIV/AIDS, viral infections, cardiovascular diseases, Alzheimer's and others as well as for other applications.

Abstract translation: 一种生产含有细菌或酵母等微生物及其高代谢产物的水解发酵培养基的方法，该方法包括提供至少一种还原成小片的固体植物产品，并与糖和生物相容性液体如牛奶混合 在35至58摄氏度的温度下进行发酵，直到培养基的酸度达到Terner度的300至900的范围。 在另一个实施方案中，通过将预定量的发芽谷物，接种有多种非病原微生物，蔬菜，水果，浆果，高蛋白质产品，草药，糖和至少一种的非生物相容性液体 化学元素如钾。 然后将混合物在选定温度下发酵一段特定的时间以达到高酸度和高浓度的细菌代谢产物。 液相从固体沉淀相分离，可用于治疗各种疾病，包括艾滋病毒/艾滋病，病毒感染，心血管疾病，阿尔茨海默氏症等，以及其他应用。

公开(公告)号：WO2009042708A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077555

申请日：2008-09-24

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： LOPATINA, Ekaterina, V. ,  KARETSKIY, Andrey, V. ,  KRYLOV, Boris, Vladimirovich

IPC: C07D315/00

CPC classification number: A61K31/351

Abstract: A regenerative anti-inflammatory composition is described to include 1 to 2 percent of comenic acid and 0.55 to 1.1 percent of sodium hydrocarbonate in a water solution, with an optional additive of up to 2.5 percent of benzyl-comenic acid. A method of treating a retinal dystrophy by injecting this composition parabulbarly or intravenously in appropriate amounts is also described. A non-peptide nature of the compound allows reducing side effects commonly associated with peptide-based compounds presently used for treatment of such dystrophy. Water-based solution of the composition is stable and amenable for storage in ampoules ready for injection thus obviating a need to make a solution from a powder, which is a common step with current treatment compounds.

Abstract translation: 描述了一种再生性抗炎组合物，其在水溶液中包含1至2％的共聚酸和0.55至1.1％的碳酸氢钠，其中任选的添加剂高达2.5％的苄基 - 苯甲酸。 还描述了通过以适量的方式或静脉内注射该组合物来治疗视网膜营养不良的方法。 化合物的非肽性质允许减少通常与目前用于治疗这种营养不良的基于肽的化合物相关的副作用。 组合物的水基溶液是稳定的并且适于储存在准备好注射的安瓿中，从而避免需要从粉末中制备溶液，这是当前处理化合物的常见步骤。

公开(公告)号：WO2008094801A2

公开(公告)日：2008-08-07

申请号：PCT/US2008/051806

申请日：2008-01-23

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： GANELIN, Boris ,  KENWORTHY, Michael, W.

CPC classification number: F01D3/00 ,  F01D11/02 ,  F04D29/0416 ,  F04D29/046 ,  F04D29/0513 ,  F04D29/056 ,  F05D2240/52 ,  F05D2240/53

Abstract: A method and apparatus to reduce the axial thrust in rotary machines such as compressors, centrifugal pumps, turbines, etc. includes providing additional peripheral restrictive means (7) attached at the peripheral portion of the disk forming the subdividing means (4) on the side facing the rotating rotor (2). An additional ring element at the periphery of the subdividing means forms additional radial (11) and axial restrictive means (15). Such peripheral restrictive means (7, 11 and 15) function as sealing dams, which combined with the outward flow induced by the rotating impeller, form self-pressurizing hydrodynamic bearings in the axial and radial planes, improving rotordynamic stability. Additionally, a stationary ring element in the center of the cavity forms a seal with the rotor, reducing leakage to suction.

Abstract translation: 减小旋转机器例如压缩机，离心泵，涡轮机等中的轴向推力的方法和装置包括提供附加的外围限制装置（7），所述外围限制装置附接在盘的外围部分，形成 细分装置（4）在面向旋转转子（2）的一侧上。 细分装置周边的附加环形元件形成附加的径向（11）和轴向限制装置（15）。 这种外围限制装置（7,11和15）用作密封坝，其与旋转叶轮引起的向外流动相结合，在轴向和径向平面中形成自增压流体动力轴承，从而改善转子动力学稳定性。 另外，空腔中心的静环元件与转子形成密封，减少泄漏到吸力。

公开(公告)号：CA2484639C

公开(公告)日：2012-01-24

申请号：CA2484639

申请日：2003-06-13

Applicant: TECHNOLOGY COMMERCIALIZATION CORP

Inventor： SOBOL CONSTANTIN V ,  SOBOL YUZEFA T

IPC: C12P1/00 ,  A23C9/12 ,  A23C9/133 ,  A23K1/00 ,  A23L1/30 ,  A23L1/305 ,  A23L7/104 ,  A23L19/20 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  C12N1/00 ,  C12N1/20

Abstract: A method of producing a hydrolyzed fermented medium containing microorganisms such as bacteria or yeast and the products of their metabolism in high concentration, the method includes providing at least one solid plant product reduced to small pieces and mixed with sugar and a biocompatible liquid such as milk for fermentation at a temperature of between 35 and 58 degrees C until the acidity of the medium reaches the range of 300 to 900 in Terner degrees. In an alternative embodiment, the medium is prepared by mixing in predetermined amounts of sprouted grains, biocompatible liquid inoculated with at least one of a variety of non-pathogenic microorganisms, vegetables, fruits, berries, high protein products, herbs, sugar, and a chemical element such as potassium. The mixture is then fermented at a selected temperature for a specified length of time to reach high acidity and high concentration of products of bacterial metabolism. A liquid phase is separated from a solid sediment phase and can be used to treat a wide variety of diseases including HIV/AIDS, viral infections, cardiovascular diseases, Alzheimer's and others as well as for other applications.