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公开(公告)号：KR1020140147281A
公开(公告)日：2014-12-30
申请号：KR1020130070245
申请日：2013-06-19
Applicant: 강원대학교산학협력단
IPC: C07C43/23 , C07C43/205 , A61K31/09 , A61P35/00
Abstract: The present invention relates to (2R,3R,4R,5R)-1,6-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)hexane-2,3,4,5-tetraol which is a novel anti-cancer functional substance unknown until now and which is manufactured by being designed by using militarin of Cordyceps militaris, and identifies anti-cancer mechanism of the compound by using various assays. The compound has an excellent effect of providing a biopharmaceutical material as an anti-cancer drug.
Abstract translation: 本发明涉及（2R，3R，4R，5R）-1,6-双（4-（2,4,4-三甲基戊-2-基）苯氧基）己烷-2,3,4,5-四醇，其中 是迄今为止未知的新型抗癌功能物质，其通过使用冬虫夏草的军药进行设计制造，并通过使用各种测定法鉴定化合物的抗癌机制。 该化合物具有提供生物药物作为抗癌药物的优异效果。
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公开(公告)号：KR1020080069414A
公开(公告)日：2008-07-28
申请号：KR1020070007103
申请日：2007-01-23
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
CPC classification number: A23L33/105 , A23L33/17 , A23V2002/00 , A23V2200/308 , A23V2250/21
Abstract: A method of manufacturing a health supplementary food using ultra-fine powder of Cordyceps sinensis obtained is provided to maximize pharmacological activity such as antioxidant, anti-inflammatory and anti-cancer effect and increase unsaturated fatty acid. Ultra-fine powder of Cordyceps sinensis is mixed with lactose in a weight ratio of 1:2 and granulated. The ultra-fine powder of Cordyceps sinensis is obtained by the steps of: drying Cordyceps sinensis at 125deg.C to a moisture content of 20% in a far infrared ray dryer in a first step and to a moisture content of less than 5% and grinding to a particle size of less than 44 micrometers at grinding speed of 80 to 90m/s.
Abstract translation: 提供使用所得冬虫夏草超细粉制造健康补充食品的方法，以最大化药理活性，如抗氧化，抗炎和抗癌作用，增加不饱和脂肪酸。 将冬虫夏草的超细粉与重量比为1：2的乳糖混合并造粒。 冬虫夏草的超细粉末通过以下步骤获得：在第一步骤中，在远红外线干燥器中将冬虫夏草在125℃干燥至含水量为20％，水分含量小于5％， 在80至90m / s的研磨速度下研磨至小于44微米的粒度。
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公开(公告)号：KR1020050092852A
公开(公告)日：2005-09-23
申请号：KR1020040017959
申请日：2004-03-17
Applicant: 강위수 , 강원대학교산학협력단 , 주식회사머쉬텍
IPC: A23L1/29
Abstract: 본 발명은 번데기 및 곡류(현미, 옥수수 등)를 첨가한 배지에서 재배한 동충하초 인공 자실체를 이용한, 물에 대한 용해도와 수용성 식이 섬유 함량이 우수한 동충하초-함유식품을 제공한다. 상기 동충하초-함유 식품은 인공 재배한 동충하초를 조파쇄한 후 탈수나 건조하여 조분말을 제조하고; 상기 조분말을 고온 고압하에서 압출성형하여 호화 및 팽화하고; 상기 압출 성형물을 분쇄하여 초미분말화하는 공정을 거쳐 다양한 분말 및 과립 제품으로 제조한다.
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公开(公告)号：KR1020090050159A
公开(公告)日：2009-05-20
申请号：KR1020070116443
申请日：2007-11-15
Applicant: 강원대학교산학협력단
IPC: A61K36/068 , A61P35/00
Abstract: 본 발명은 붉은자루동충하초 추출물을 유효성분으로 하는 항암 치료제에 관한 것으로, 붉은자루 동충하초의 부탄올 분획물은 카스파아제 경로를 통한 아폽토시스뿐만 아니라, Bax 및 Bad의 발현을 증가시키고, Bcl-2의 발현을 억제하며, 카스파아제 비의존경로인 AIF의 핵 내로의 전달(translocation)작용을 통해 항암작용을 하는 뛰어난 효과가 있다.
붉은자루동충하초, 부탄올 분획물, 카스파아제, Bax,Bad, Bcl-2, AIF-
公开(公告)号：KR1020150014033A
公开(公告)日：2015-02-06
申请号：KR1020130088704
申请日：2013-07-26
Applicant: 강원대학교산학협력단
IPC: A61K36/066 , A61K36/068 , A61P1/16
Abstract: 본 발명은 지금까지 알려지지 않은 신규 항암기능성 물질인 번데기동충하초 물추출물인 CMWE를 제조하고 상기 화합물의 간암세포 억제 효과를 다양한 실험을 통해 규명한 발명에 관한 것으로 항암제로서 생물 의약 소재를 제공하는 뛰어난 효과가 있다.
Abstract translation: 本发明涉及通过各种实验研究的作为新型抗癌功能物质的冬虫夏草（CMWE）的水提取物对肝细胞癌细胞的抑制作用。 本发明提供了作为抗肿瘤剂的生物药物。 制备CMWE的方法包括以下步骤：从冬虫夏草提取和纯化功能物质; 培养正常细胞的人肝癌细胞株（HepG2）和人肝细胞系（Chang）; 用肝毒性诱导物质处理人肝细胞系，培养人肝细胞系，测定细胞活力; 使用高效液相色谱（HPLC）进行分析; 并使用流式细胞仪分析，并进行蛋白质印迹检测CMWE对肝细胞损伤的保护作用的生化机制。
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Patent Agency Ranking6.发明公开
公开(公告)号：KR1020140081958A
公开(公告)日：2014-07-02
申请号：KR1020120150243
申请日：2012-12-21
Applicant: 강원대학교산학협력단
IPC: A61K36/068 , A61K36/066 , A61P29/00
Abstract: The present invention relates to an anti-inflammatory active composition containing a Beauveria sungii butanol fraction (BSBF) as an active ingredient. The BSBF according to the present invention inhibits the activation of NFkB by controlling the generation of NO caused by iNOS and COX-2 which are known as important factors of inflammatory reaction and by controlling the phoshorylation of IkB so that COX-2 expression is controlled. The BSBF also controls ROS generation so that the expressions of NFKB and p38 are controlled and inflammation can be effectively controlled.
Abstract translation: 本发明涉及含有白色念珠菌丁醇级分（BSBF）作为活性成分的抗炎活性组合物。 根据本发明的BSBF通过控制由已知作为炎性反应的重要因子的iNOS和COX-2引起的NO的产生以及通过控制IkB的磷酸化从而抑制NFκB的活化，从而控制COX-2的表达。 BSBF还控制ROS产生，从而控制NFκB和p38的表达并有效控制炎症。
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公开(公告)号：KR1020100100489A
公开(公告)日：2010-09-15
申请号：KR1020090019407
申请日：2009-03-06
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
Inventor： 김태웅
IPC: A61K36/066 , A61P29/00 , A23L1/30
Abstract: PURPOSE: A pharmaceutical composition containing Cordyceps Bassiana extract for anti-inflammatory activity is provided to suppress IkB, p-Akt, p-p38, Erk, and JNK. CONSTITUTION: A pharmaceutical composition for anti-inflammatory activity contains Cordyceps bassiana extract as an active ingredient. The Cordyceps bassiana extract is a butanol fraction. The Cordyceps bassiana butanol fraction is obtained by extracting Cordyceps bassiana fruit body with ethanol and fractioning with butanol. A health food composition with anti-inflammatory activity contains Cordyceps bassiana extract as an active ingredient.
Abstract translation: 目的：提供含有冬虫夏草提取物抗炎活性的药物组合物，以抑制IkB，p-Akt，p-p38，Erk和JNK。 构成：抗炎活性药物组合物含有冬虫夏草提取物作为活性成分。 冬虫夏草提取物是丁醇级分。 冬虫夏草丁酸丁酯级分用乙醇提取冬虫夏草果实，用丁醇分馏得到。 具有抗炎活性的保健食品组合物含有冬虫夏草提取物作为活性成分。
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公开(公告)号：KR1020090036925A
公开(公告)日：2009-04-15
申请号：KR1020070102227
申请日：2007-10-10
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
IPC: A61K36/066 , A61P29/00
Abstract: An anti-inflammatory agent comprising cordyceps militaris extracts as an active ingredient is provided to suppress an inflammation-inducing material through the route of PI3k/AKT/IkB and the route of suppressing phosphorylation of p38 by using butanol fraction of methanol extract and cordycepin purified therefrom. A method for manufacturing butanol fraction for treating inflammation from Cordyceps militaris comprises the steps of: (a) melting methanol extract of Cordyceps militaris in water; (b) fractionating hexane, butanol, ethylacetate and water; and (c) removing solvent by decompressing the butanol fraction.
Abstract translation: 提供包含冬虫夏草提取物作为活性成分的抗炎剂，以通过使用PI3K / AKT / IkB的途径抑制炎症诱导物质，并通过使用甲醇提取物的丁醇级分和从其中纯化的冬虫夏草来抑制磷酸化p38的途径 。 制备用于治疗冬虫夏草炎症的丁醇级分的方法包括以下步骤：（a）在水中熔化冬虫夏草的甲醇提取物; （b）分馏己烷，丁醇，乙酸乙酯和水; 和（c）通过减压丁醇馏分除去溶剂。
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公开(公告)号：KR100852464B1
公开(公告)日：2008-08-18
申请号：KR1020070007103
申请日：2007-01-23
Applicant: 강원대학교산학협력단 , 주식회사머쉬텍
Abstract: 본 발명은 동충하초의 초미분을 이용한 건강보조식품 및 그 제조방법에 관한 것으로, 원적외선 건조기를 통해 건조된 동충하초를 초미분쇄하여 수용성이 증대되고, 불포화지방산이 증가되고, 항산화, 항염증 및 항암효과가 증가된 기능성 제품을 제조함으로써 종래의 티백제품보다 약리활성이 극대화된 제품을 제공하는 뛰어난 효과가 있다.
동충하초, 원적외선 건조, 초미분쇄, 생리활성-
10.发明授权2,6-Dibenzyl-4-chlorophenol 화합물을 유효성분으로 하는 암예방 및 치료용 약학적 조성물 有权26-二苄基-4-氯苯酚用于预防或治疗癌症的药物组合物包含26-二苄基-4-氯苯酚化合物
公开(公告)号：KR101699201B1
公开(公告)日：2017-01-24
申请号：KR1020160006228
申请日：2016-01-19
Applicant: 강원대학교산학협력단
Abstract: 본발명은 2,6-Dibenzyl-4-chlorophenol 화합물을유효성분으로함유하는암 예방및 치료용조성물에관한것으로, 2,6-Dibenzyl-4-chlorophenol 화합물이 A549세포, DU145세포, Hela세포및 HepG2세포에서농도의존적으로암세포의증식을억제하였으므로본 발명의 2,6-Dibenzyl-4-chlorophenol 화합물은암 예방및 치료용약학적조성물로유용하게사용될수 있다.
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