公开(公告)号：KR100840558B1

公开(公告)日：2008-06-23

申请号：KR1020070022768

申请日：2007-03-08

Applicant: 강원대학교산학협력단

Inventor： 조동하 ,  조재열 ,  이용규 ,  김주영 ,  변세은 ,  박형재 ,  유창연 ,  이한신 ,  김성무

IPC: A61K36/185 ,  A61P29/00 ,  A61P37/02

Abstract: An extract of Hibiscus cannabinus L., Malvaceae is provided to control the function of macrophage by inhibiting generation of TNF-alpha, mRNA expression of interleukin(IL)-3 and IL-12, and generation of nitric oxide(NO), prostaglandin(PGE2) and reactive oxygen species(PROS), thereby being useful for preventing and treating diseases by immuno-reaction. A pharmaceutical composition for preventing and treating inflammation comprises an extract of Hibiscus cannabinus L. Malvaceae as an effective ingredient, wherein the extract is prepared by extracting the Hibiscus cannabinus L. with at least one solvent selected from the group consisting of water, C1-4 alcohol, glycerol, propylene glycol, 1,3-butyleneglycol, ethylacetate, benzene, hexane, diethyl ether and dichloromethane, filtering the extract and concentrating the filtrate.

Abstract translation: 提供芙蓉大麻提取物，通过抑制TNF-α的产生，白细胞介素（IL）-3和IL-12的mRNA表达以及一氧化氮（NO），前列腺素（NO）的产生来控制巨噬细胞的功能， PGE2）和活性氧（PROS），因此可用于通过免疫反应预防和治疗疾病。 用于预防和治疗炎症的药物组合物包含芙蓉大戟科的提取物作为有效成分，其中所述提取物是通过用至少一种选自水，C 1-4的溶剂萃取木槿大麻制备的 醇，甘油，丙二醇，1,3-丁二醇，乙酸乙酯，苯，己烷，乙醚和二氯甲烷，过滤提取物并浓缩滤液。