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公开(公告)号：KR1020110128068A
公开(公告)日：2011-11-28
申请号：KR1020100047683
申请日：2010-05-20
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A61P29/00 , A23L33/00 , A23L1/30
Abstract: PURPOSE: A composition containing Hopea odorata Roxb. extract with anti-inflammation is provided to control macrophage function and to prevent and treat acure/chronic inflammation immunity and autoimmune response. CONSTITUTION: A pharmaceutical composition contains Hopea odorata Roxb. extract as an active ingredient. The extract is isolated using methanol, ethanol, or water. The extract is prepared by isolating Hopea odorata Roxb. with ethanol, suspending with water, and fractioning with n-hexane, ethyl acetate, and n-butanol. The extract is prepared in the form of a carrier, excipient, or diluent. The extract suppresses NO generation and pro-inflammatory cytokines(IL-6, GM-CSF, IL-1β and TNF-alpha). A neutraceutical food contains the hot water extract of Hopea odorata Roxb. as an active ingredient.
Abstract translation: 目的：含有Hopea odorata Roxb的组合物。 提供具有抗炎作用以控制巨噬细胞功能并预防和治疗急性/慢性炎症免疫和自身免疫应答。 组成：药物组合物含有Hopea odorata Roxb。 提取物作为活性成分。 使用甲醇，乙醇或水分离提取物。 提取物通过分离Hopea odorata Roxb制备。 用乙醇悬浮，用正己烷，乙酸乙酯和正丁醇分级。 提取物以载体，赋形剂或稀释剂的形式制备。 提取物抑制NO产生和促炎细胞因子（IL-6，GM-CSF，IL-1β和TNF-α）。 一种中性食品含有Hopea odorata Roxb的热水提取物。 作为活性成分。
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公开(公告)号：KR101084727B1
公开(公告)日：2011-11-22
申请号：KR1020090043098
申请日：2009-05-18
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61K8/97 , A61P17/04 , A23L1/30
Abstract: 본 발명은 더덕 추출물 또는 더덕 사포닌을 유효성분으로 포함하는 비만세포로부터 히스타민의 분비를 억제하는 효과를 갖는 조성물에 관한 것이다.
본 발명의 조성물과 이를 포함하는 제품은 소양증을 비롯하여 발적, 화끈거리는 열감, 두드러기, 재채기, 맑은 콧물, 코막힘, 객담증가, 흉부압박감, 호흡곤란, 순환기계의 빈맥, 저혈압, 전신 무기력증, 어지러움증과 같은 히스타민의 필요이상의 분비로 인하여 발생되는 질병이나 증상의 예방 또는 치료용도로 사용될 수 있다.
본 발명의 조성물 및 이를 함유하는 제품은 사람뿐만 아니라 동물에도 적용할 수 있다.
더덕, 사포닌, 소양증, 비만세포, 탈과립, 히스타민-
3.发明授权
公开(公告)号：KR101141779B1
公开(公告)日：2012-05-03
申请号：KR1020090035529
申请日：2009-04-23
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61P17/14 , A23L1/30 , A61K8/97
Abstract: 본 발명은 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 발모 또는 양모 촉진용 조성물 및 이를 포함하는 피부외용제 또는 기능성 식품에 관한 것이다.
본 발명은 또한 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 조성물을 사용하여 발모 또는 양모를 촉진하는 방법을 제공한다.
본 발명의 조성물 및 이를 함유하는 제품은 사람 뿐만 아니라 애완동물이나, 털을 채취하거나 모피를 이용하는 동물에 적용할 수 있다.
더덕, 사포닌, 발모, 양모-
4.发明公开
公开(公告)号：KR1020090015766A
公开(公告)日：2009-02-12
申请号：KR1020070080366
申请日：2007-08-09
Applicant: 강원대학교산학협력단
IPC: A61K31/435 , A61P29/00 , A61P37/02 , A61P35/00
CPC classification number: Y02A50/409 , A61K31/435 , Y10S514/814 , Y10S514/824 , Y10S514/825 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/925
Abstract: A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.
Abstract translation: 提供了包含8-（甲苯磺酰氨基）喹啉的组合物以抑制一氧化氮的产生，癌细胞和C6胶质瘤细胞的生长，PGE2（前列腺素2）的产生以及IKK（IκBα激酶）和Src激酶的活性， 从而预防或治疗炎性疾病，免疫疾病或肿瘤。 用于预防或治疗炎性疾病，免疫疾病或肿瘤的组合物包含8-（甲苯磺酰氨基）喹啉或其药学上可接受的盐，包括选自盐酸，氢溴酸，膦酸，硫酸，酒石酸，乙酸， 柠檬酸，苹果酸，甲磺酸和葡萄糖酸。
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5.发明公开5-[4’-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-에이]이소퀴놀린을 함유하는 염증성 질병 또는 면역질환의예방 또는 치료용 조성물 有权包含（5- [4' - （哌啶子基）苯基] -2,3-二氢吡啶并[2,1-A]异喹啉）的组合物，用于预防或治疗炎症或免疫疾病
公开(公告)号：KR1020090007655A
公开(公告)日：2009-01-20
申请号：KR1020070070926
申请日：2007-07-15
Applicant: 강원대학교산학협력단
IPC: A61K31/47 , A61K31/4184 , A61P37/02
CPC classification number: Y02A50/409 , Y02A50/423 , A61K31/4745 , Y10S424/13 , Y10S514/814 , Y10S514/824 , Y10S514/825 , Y10S514/866 , Y10S514/886 , Y10S514/893 , Y10S514/925
Abstract: A composition comprising 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline is provided to inhibit inflammation and regulate immune responses in macrophages, thereby preventing and treating the inflammatory or immune diseases. The composition for prevention and treatment of inflammatory or immune diseases comprises 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline or its pharmaceutically acceptable salt, and inhibits the expression of any one proinflammatory cytokine selected from the group consisting of IL-1(interleukin) beta, IL-6 and TNF-alpha(tumor necrosis factor-alpha).
Abstract translation: 提供包含5- [4' - （哌啶子基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉的组合物，以抑制炎症和调节巨噬细胞中的免疫应答，从而预防和治疗炎症或免疫疾病。 用于预防和治疗炎症或免疫疾病的组合物包括5- [4' - （哌啶基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉或其药学上可接受的盐，并且抑制任何一种 选自IL-1（白介素）β，IL-6和TNF-α（肿瘤坏死因子-α）的促炎细胞因子。
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Patent Agency Ranking
公开(公告)号：KR100840558B1
公开(公告)日：2008-06-23
申请号：KR1020070022768
申请日：2007-03-08
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A61P29/00 , A61P37/02
Abstract: An extract of Hibiscus cannabinus L., Malvaceae is provided to control the function of macrophage by inhibiting generation of TNF-alpha, mRNA expression of interleukin(IL)-3 and IL-12, and generation of nitric oxide(NO), prostaglandin(PGE2) and reactive oxygen species(PROS), thereby being useful for preventing and treating diseases by immuno-reaction. A pharmaceutical composition for preventing and treating inflammation comprises an extract of Hibiscus cannabinus L. Malvaceae as an effective ingredient, wherein the extract is prepared by extracting the Hibiscus cannabinus L. with at least one solvent selected from the group consisting of water, C1-4 alcohol, glycerol, propylene glycol, 1,3-butyleneglycol, ethylacetate, benzene, hexane, diethyl ether and dichloromethane, filtering the extract and concentrating the filtrate.
Abstract translation: 提供芙蓉大麻提取物，通过抑制TNF-α的产生，白细胞介素（IL）-3和IL-12的mRNA表达以及一氧化氮（NO），前列腺素（NO）的产生来控制巨噬细胞的功能， PGE2）和活性氧（PROS），因此可用于通过免疫反应预防和治疗疾病。 用于预防和治疗炎症的药物组合物包含芙蓉大戟科的提取物作为有效成分，其中所述提取物是通过用至少一种选自水，C 1-4的溶剂萃取木槿大麻制备的 醇，甘油，丙二醇，1,3-丁二醇，乙酸乙酯，苯，己烷，乙醚和二氯甲烷，过滤提取物并浓缩滤液。
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公开(公告)号：KR1020100124054A
公开(公告)日：2010-11-26
申请号：KR1020090043098
申请日：2009-05-18
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61K8/97 , A61P17/04 , A23L1/30
Abstract: PURPOSE: A composition containing Codonopis lanceolata extract or Codonopis lanceolata saponin is provided to prevent or treat diseases or symptom caused by excessive histamine secretion. CONSTITUTION: A composition for suppressing histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. A composition for preventin or treating disease or symptom caused by excessive histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. The diseases or symptom caused by excessive histamine secretion is pruritus, rhinorrhea, nasal obstruction, idle talk increase, chest pressure feeling, respiratory distress, circulating machine, and hypotension. A pharmaceutical composition for preventing or treating pruritus contains Codonopis lanceolata saponin as an active ingredient.
Abstract translation: 目的：提供含有Codonopis lanceolata提取物或Codonopis lanceolata皂苷的组合物，用于预防或治疗由过量组胺分泌引起的疾病或症状。 构成：用于抑制组胺分泌的组合物含有爪蟾属（Codonopis lanceolata）或爪蟾属（Codonopis lanceolata saponin）作为活性成分。 用于预防或治疗由过度组胺分泌引起的疾病或症状的组合物含有角叉菜（Cloonopis lanceolata）或爪蟾属（Codonopis lanceolata saponin）作为活性成分。 由组胺分泌过多引起的疾病或症状是瘙痒，鼻漏，鼻塞，空闲谈话增加，胸压感，呼吸窘迫，循环机和低血压。 用于预防或治疗瘙痒症的药物组合物含有作为活性成分的角叉菜皂甙皂甙。
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公开(公告)号：KR100954103B1
公开(公告)日：2010-04-23
申请号：KR1020090115946
申请日：2009-11-27
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A hydroquinone(HQ) derivative having anti-inflammation and immunity properties is provided to reduce NO generation by suppressing PDK1/Akt(protein kinase B) and to treat or prevent inflammation and septic shock. CONSTITUTION: A hydroquinone derivative compound is denoted by chemical formula 1. The hydroquinone derivative compound is 2-Allylbenzene-1,4-diol, (E)-2-(4-Hydroxy-3-methylbut-2-enyl)benzene-1,4-diol, (E)-2-(3-Methylnon-2-enyl)benzene-1,4-diol, (E)-2-(9-Hydroxy-3-methylnon-2-enyl) benzene-1,4-diol, and (E) -2 - (3-Methylhex-2-enyl) benzene-1,4-diol. A composition for preventing or treating septic shock contains the hydroquinone derivative compound of chemical formula 1. A health food for preventing or treating septic shock contains the hydroquinone derivative compound and a sitologically acceptable food supplement.
Abstract translation: 目的：提供具有抗炎和免疫性质的氢醌（HQ）衍生物，通过抑制PDK1 / Akt（蛋白激酶B）和治疗或预防炎症和败血性休克来减少NO产生。 构成：氢醌衍生物化合物由化学式1表示。氢醌衍生物化合物为2-烯丙基苯-1,4-二醇，（E）-2-（4-羟基-3-甲基丁-2-烯基）苯-1 ，（E）-2-（3-甲基壬-2-烯基）苯-1,4-二醇，（E）-2-（9-羟基-3-甲基壬-2-烯基）苯-1 ，4-二醇和（E）-2-（3-甲基己-2-烯基）苯-1,4-二醇。 用于预防或治疗脓毒性休克的组合物含有化学式1的氢醌衍生物化合物。用于预防或治疗败血性休克的保健食品含有氢醌衍生物化合物和可食用的食品补充剂。
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9.发明授权조혈모세포 증식을 갖는 더덕의 부탄올 분획을 함유하는 건강식품 조성물 失效包含丁醇溶液提取物的健康食品的组合物具有HEMATOPOIETIC STEM细胞增殖活性的腐败性土耳其BENTH ET HOOK
公开(公告)号：KR100921909B1
公开(公告)日：2009-10-16
申请号：KR1020080134155
申请日：2008-12-26
Applicant: 강원대학교산학협력단
CPC classification number: A23L2/38 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2200/324 , A23V2250/21
Abstract: PURPOSE: A health food composition containing the butanol fraction of Condonopsis lanceolata is provided to ensure immunological enhancement and anticancer activity. CONSTITUTION: A method for preparing a health food composition containing the butanol fraction of Condonopsis lanceolata comprises the following steps of: extracting Condonopsis lanceolata roots in 5-10 times the amount of hot water and suspending the Condonopsis lanceolata extract in 5-10 times the amount of water; and fraction-extracting it in 5-10 times the amount of hexane, 5-10 times the amount of ethylacetate, and 5-10 times the amount of butanol in sequential order.
Abstract translation: 目的：提供一种保健食品组合物，其中含有黄连杆菌的丁醇馏分，以确保免疫增强和抗癌活性。 构成：一种制备含有堇菜多糖的丁醇馏分的保健食品组合物的方法，包括以下步骤：以5-10倍量的热水提取堇菜根，并将康宁茯苓提取物悬浮5-10倍量 的水; 并以5-10倍量的己烷分数提取5-10倍量乙酸乙酯，按顺序加入5-10倍量的丁醇。
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10.发明授权5-[4’-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-에이]이소퀴놀린을 함유하는 염증성 질병 또는 면역질환의예방 또는 치료용 조성물 有权包含5- [4'-哌啶基甲基苯基] -2,3-二氢咪唑并[2,1-a]异喹啉的组合物，用于预防或治疗炎性或免疫疾病
公开(公告)号：KR100888706B1
公开(公告)日：2009-03-16
申请号：KR1020070070926
申请日：2007-07-15
Applicant: 강원대학교산학협력단
IPC: A61K31/47 , A61K31/4184 , A61P37/02
CPC classification number: Y02A50/409 , Y02A50/423
Abstract: 본 발명은 5-[4'-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-a]이소퀴놀린의 신규한 의약용도에 관한 것으로서, 더욱 상세하게는 염증반응인자로서의 종양괴사인자 (TNF)-알파의 생성 억제, 종양괴사인자 (TNF)-알파, 인터류킨(IL)-1 베타 및 인터류킨-6의 mRNA 발현 억제, 식세포 작용 능력 억제 및 산화질소(nitric oxide, NO) 생성 억제의 효과를 기초 한 염증성 질병 또는 면역질환의 예방 또는 치료용도에 관한 것이다.
5-[4'-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-a]이소퀴놀린, 항염증활성, 대식세포, 사이토카인
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