Abstract:
PURPOSE: A composition containing Hopea odorata Roxb. extract with anti-inflammation is provided to control macrophage function and to prevent and treat acure/chronic inflammation immunity and autoimmune response. CONSTITUTION: A pharmaceutical composition contains Hopea odorata Roxb. extract as an active ingredient. The extract is isolated using methanol, ethanol, or water. The extract is prepared by isolating Hopea odorata Roxb. with ethanol, suspending with water, and fractioning with n-hexane, ethyl acetate, and n-butanol. The extract is prepared in the form of a carrier, excipient, or diluent. The extract suppresses NO generation and pro-inflammatory cytokines(IL-6, GM-CSF, IL-1β and TNF-alpha). A neutraceutical food contains the hot water extract of Hopea odorata Roxb. as an active ingredient.
Abstract:
본 발명은 더덕 추출물 또는 더덕 사포닌을 유효성분으로 포함하는 비만세포로부터 히스타민의 분비를 억제하는 효과를 갖는 조성물에 관한 것이다. 본 발명의 조성물과 이를 포함하는 제품은 소양증을 비롯하여 발적, 화끈거리는 열감, 두드러기, 재채기, 맑은 콧물, 코막힘, 객담증가, 흉부압박감, 호흡곤란, 순환기계의 빈맥, 저혈압, 전신 무기력증, 어지러움증과 같은 히스타민의 필요이상의 분비로 인하여 발생되는 질병이나 증상의 예방 또는 치료용도로 사용될 수 있다. 본 발명의 조성물 및 이를 함유하는 제품은 사람뿐만 아니라 동물에도 적용할 수 있다. 더덕, 사포닌, 소양증, 비만세포, 탈과립, 히스타민
Abstract:
본 발명은 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 발모 또는 양모 촉진용 조성물 및 이를 포함하는 피부외용제 또는 기능성 식품에 관한 것이다. 본 발명은 또한 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 조성물을 사용하여 발모 또는 양모를 촉진하는 방법을 제공한다. 본 발명의 조성물 및 이를 함유하는 제품은 사람 뿐만 아니라 애완동물이나, 털을 채취하거나 모피를 이용하는 동물에 적용할 수 있다. 더덕, 사포닌, 발모, 양모
Abstract:
A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.
Abstract:
A composition comprising 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline is provided to inhibit inflammation and regulate immune responses in macrophages, thereby preventing and treating the inflammatory or immune diseases. The composition for prevention and treatment of inflammatory or immune diseases comprises 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline or its pharmaceutically acceptable salt, and inhibits the expression of any one proinflammatory cytokine selected from the group consisting of IL-1(interleukin) beta, IL-6 and TNF-alpha(tumor necrosis factor-alpha).
Abstract:
An extract of Hibiscus cannabinus L., Malvaceae is provided to control the function of macrophage by inhibiting generation of TNF-alpha, mRNA expression of interleukin(IL)-3 and IL-12, and generation of nitric oxide(NO), prostaglandin(PGE2) and reactive oxygen species(PROS), thereby being useful for preventing and treating diseases by immuno-reaction. A pharmaceutical composition for preventing and treating inflammation comprises an extract of Hibiscus cannabinus L. Malvaceae as an effective ingredient, wherein the extract is prepared by extracting the Hibiscus cannabinus L. with at least one solvent selected from the group consisting of water, C1-4 alcohol, glycerol, propylene glycol, 1,3-butyleneglycol, ethylacetate, benzene, hexane, diethyl ether and dichloromethane, filtering the extract and concentrating the filtrate.
Abstract:
PURPOSE: A composition containing Codonopis lanceolata extract or Codonopis lanceolata saponin is provided to prevent or treat diseases or symptom caused by excessive histamine secretion. CONSTITUTION: A composition for suppressing histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. A composition for preventin or treating disease or symptom caused by excessive histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. The diseases or symptom caused by excessive histamine secretion is pruritus, rhinorrhea, nasal obstruction, idle talk increase, chest pressure feeling, respiratory distress, circulating machine, and hypotension. A pharmaceutical composition for preventing or treating pruritus contains Codonopis lanceolata saponin as an active ingredient.
Abstract:
PURPOSE: A hydroquinone(HQ) derivative having anti-inflammation and immunity properties is provided to reduce NO generation by suppressing PDK1/Akt(protein kinase B) and to treat or prevent inflammation and septic shock. CONSTITUTION: A hydroquinone derivative compound is denoted by chemical formula 1. The hydroquinone derivative compound is 2-Allylbenzene-1,4-diol, (E)-2-(4-Hydroxy-3-methylbut-2-enyl)benzene-1,4-diol, (E)-2-(3-Methylnon-2-enyl)benzene-1,4-diol, (E)-2-(9-Hydroxy-3-methylnon-2-enyl) benzene-1,4-diol, and (E) -2 - (3-Methylhex-2-enyl) benzene-1,4-diol. A composition for preventing or treating septic shock contains the hydroquinone derivative compound of chemical formula 1. A health food for preventing or treating septic shock contains the hydroquinone derivative compound and a sitologically acceptable food supplement.
Abstract:
PURPOSE: A health food composition containing the butanol fraction of Condonopsis lanceolata is provided to ensure immunological enhancement and anticancer activity. CONSTITUTION: A method for preparing a health food composition containing the butanol fraction of Condonopsis lanceolata comprises the following steps of: extracting Condonopsis lanceolata roots in 5-10 times the amount of hot water and suspending the Condonopsis lanceolata extract in 5-10 times the amount of water; and fraction-extracting it in 5-10 times the amount of hexane, 5-10 times the amount of ethylacetate, and 5-10 times the amount of butanol in sequential order.
Abstract:
본 발명은 5-[4'-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-a]이소퀴놀린의 신규한 의약용도에 관한 것으로서, 더욱 상세하게는 염증반응인자로서의 종양괴사인자 (TNF)-알파의 생성 억제, 종양괴사인자 (TNF)-알파, 인터류킨(IL)-1 베타 및 인터류킨-6의 mRNA 발현 억제, 식세포 작용 능력 억제 및 산화질소(nitric oxide, NO) 생성 억제의 효과를 기초 한 염증성 질병 또는 면역질환의 예방 또는 치료용도에 관한 것이다. 5-[4'-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-a]이소퀴놀린, 항염증활성, 대식세포, 사이토카인