公开(公告)号：WO2017159912A1

公开(公告)日：2017-09-21

申请号：PCT/KR2016/003209

申请日：2016-03-29

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은정 ,  안은영 ,  전영희

IPC: A23L1/30 ,  A61K36/605 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K9/20 ,  A61K9/48 ,  A61K36/605

Abstract: 본 발명은 상지 열수추출물 및 상지 지표성분인 ORT를 함유하는 항당뇨 조성물에 관한 것으로 Streptozotocin 유도 당뇨쥐에 투여하여 상백피 열수추출물과 비교했을 때 소장 이당류분해효소 활성을 억제하여 혈당을 낮추고 혈장 내 지질 개선 효과가 더 뛰어날 뿐만 아니라 간 조직 내로 포도당 유입을 증가시키고 글리코겐 합성을 증가시켜 혈당강하 효과를 확인함으로써 상지 열수추출물 및 상지 지표성분인 ORT를 함유하는 당뇨 예방 및 치료 기능성 의약품 및 식품 조성물로 이용할 수 있는 뛰어난 효과가 있다.

Abstract translation:

抑制本发明的上肢热水提取物和小肠二糖裂合酶活性的上肢表面组分当给予链脲佐菌素诱导的糖尿病大鼠涉及含有ORT抗糖尿病组合物与森皮质热水提取物相比 通过增加葡萄糖流入肝脏组织以降低血液葡萄糖血浆以及脂质更通过验证含有的官能上肢热水提取物和ORT糖尿病预防上肢表面组分和治疗的降血糖作用练成改进和增加的糖原合成 有很好的效果，可用于药品和食品组合物。

公开(公告)号：KR1020170108222A

公开(公告)日：2017-09-27

申请号：KR1020160031775

申请日：2016-03-17

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은정 ,  안은영 ,  전영희

IPC: A23L1/30 ,  A61K36/605 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K9/20 ,  A61K9/48 ,  A61K36/605

Abstract: 본발명은상지열수추출물및 상지지표성분인 ORT를함유하는항당뇨조성물에관한것으로 Streptozotocin 유도당뇨쥐에투여하여상백피열수추출물과비교했을때 소장이당류분해효소활성을억제하여혈당을낮추고혈장내 지질개선효과가더 뛰어날뿐만아니라간 조직내로포도당유입을증가시키고글리코겐합성을증가시켜혈당강하효과를확인함으로써상지열수추출물및 상지지표성분인 ORT를함유하는당뇨예방및 치료기능성의약품및 식품조성물로이용할수 있는뛰어난효과가있다.

Abstract translation: 本发明上肢热水提取物和链脲佐菌素通过向小鼠施用诱导的糖尿病桑热水提取物的脂质相比，通过在含有ORT上肢指示器部件的抗糖尿病组合物抑制小肠二糖分解酶的活性提高了血浆降低血糖 效果更练成不仅增加了葡萄糖流入肝组织以及与增加的糖原合成通过检查血糖降低作用，这将能够使用它作为糖尿病预防和治疗功能的药物和含有所述上肢，所述热水提取物和上肢表面部件ORT的食物组合物 它有很好的效果。

公开(公告)号：KR1020130093372A

公开(公告)日：2013-08-22

申请号：KR1020120014928

申请日：2012-02-14

Applicant: 대구가톨릭대학교산학협력단 ,  최상원

Inventor： 최상원 ,  김은옥 ,  임현희

IPC: A61K36/605 ,  A61K36/60 ,  A61K31/045 ,  A61K31/05

CPC classification number: A61K8/97 ,  A61K36/605 ,  A61K2236/10 ,  A61K2236/19 ,  A61K2236/33 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/844 ,  Y10S514/857

Abstract: PURPOSE: A method for preparing a mulberry branch extract is provided to produce a large amount of purified powder containing oxyresveratrol with anti-inflammatory and antiaging functions and to use trans-rasveratrol and moracin as a novel material for functional foods and cosmetic products. CONSTITUTION: A method for preparing a mulberry branch extract containing oxyresveratrol comprises the steps of: steaming mulberry branches for one hour and drying; adding 650 kg of a 75-95% ethanol solution to 100 kg of the dried mulberry branches and extracting by ultrasonic wave at 40-50°C for 12 hours; concentrating the extract by reduced pressure; dissolving the concentrate in a 80% ethanol solution and incubating at room temperature; removing precipitate, adding normal-hexane, and fractioning; removing an upper layer oil and concentrating the lower layer; adding a 20% ethanol solution to the defatted ethanol extract of mulberry branches and suspending; treating the defatted ethanol extract with 10% pectinase and hydrolyzing at 30-40°C for 12 hours to obtain a hydrolysate; fractioning the hydrolysate with an ethyl acetate solvent and concentrating the upper layer by reduced pressure; dissolving the concentrate using the 20% ethanol solution and adsorbing onto diaion HP-20 adsorption ion exchange column; washing the resultant with the 20% ethanol solution; and eluting the resultant with a 40% ethanol solution and concentrating. [Reference numerals] (AA) Dried mulberry branches(100kg); (BB) CNCNF(650kg, 80% ethanol solution, ultrasonic extractor, 50°C, 12 hours, twice); (CC) Filter; (DD) Filtered liquid; (EE, LL) Concentrate by reduced pressure; (FF) Ethanol extract of the mulberry branches(10kg); (GG) Re-dissolve(50kg, ethanol solution); (HH) Incubate day and night; (II) Supernatant; (JJ) Defatting(100kg, normal-hexane); (KK) Lower layer; (MM) Defatted ethanol extract of mulberry branches(8.5kg); (NN) Suspend(50kg, 20% ethanol solution); (OO) Enzyme treatment(4L, pectinex 5 XL, 30~40°C, 12 hours); (PP) Cooling; (QQ) Fraction with a solvent(100kg, ethyl acetate, twice); (RR) Dehydrate(10kg, sodium sulfate anhydrous); (SS) Filter and concentrate by reduced pressure; (TT) Ethyl acetate extract(2.1kg); (UU) Diaion HP-20 column chromatography; (VV) Fraction with 40% ethanol solution; (WW) Fraction with 60% ethanol solution; (XX) Mulberry branch extract I(1.2kg); (YY) Mulberry branch extract II(110g)

Abstract translation: 目的：提供一种桑树枝提取物的制备方法，以产生大量具有抗炎和抗衰老作用的含有羟基维生素的纯化粉末，并使用反式西伐他汀和莫拉辛作为功能性食品和化妆品的新型材料。 构成：含有羟基维生素的桑树分枝提取物的制备方法，包括：蒸桑桑干1小时，干燥; 向100公斤干桑树中加入650公斤75-95％乙醇溶液，超声波在40-50℃下萃取12小时; 减压浓缩提取物; 将浓缩物溶解在80％乙醇溶液中并在室温下孵育; 除去沉淀，加正己烷，分馏; 去除上层油并浓缩下层; 向桑树脱脂乙醇提取物中加入20％乙醇溶液悬浮; 用10％果胶酶处理脱脂乙醇提取物，并在30-40℃下水解12小时，得到水解产物; 用乙酸乙酯溶剂分级水解产物，减压浓缩上层; 使用20％乙醇溶液溶解浓缩物，并吸附在悬浮HP-20吸附离子交换柱上; 用20％乙醇溶液洗涤所得物; 并用40％乙醇溶液洗脱所得物并浓缩。 （附图标记）（AA）干桑树枝（100kg）; （BB）CNCNF（650kg，80％乙醇溶液，超声波提取器，50℃，12小时，两次）; （CC）过滤器; （DD）过滤液体; （EE，LL）减压浓缩; （FF）桑树分支乙醇提取物（10kg）; （GG）再溶解（50kg，乙醇溶液）; （HH）昼夜孵化; （二）上清液; （JJ）脱脂（100kg，正己烷）; （KK）下层; （MM）桑叶脱乙醇提取物（8.5kg）; （NN）悬浮液（50kg，20％乙醇溶液）; （OO）酶处理（4L，pectinex 5 XL，30〜40℃，12小时）; （PP）冷却; （QQ）用溶剂（100kg，乙酸乙酯，2次）分级; （RR）脱水（10kg，无水硫酸钠）; （SS）通过减压过滤和浓缩; （TT）乙酸乙酯提取物（2.1kg）; （UU）Diaion HP-20柱色谱; （VV）用40％乙醇溶液分级; （WW）用60％乙醇溶液分级; （XX）桑树枝提取物I（1.2kg）; （YY）桑树枝提取物II（110g）

公开(公告)号：KR1020130000114A

公开(公告)日：2013-01-02

申请号：KR1020110060606

申请日：2011-06-22

Applicant: 서미자 ,  대구가톨릭대학교산학협력단

Inventor： 서미자 ,  최상원 ,  김은옥 ,  임현희

IPC: A61K36/234 ,  A61K36/232 ,  A61P29/00

Abstract: PURPOSE: An herbal mist for treating inflammation using a steam distilled extract of various medicinal herbs is provided to ensure excellent antioxidative and anti-inflammatory effects. CONSTITUTION: A cosmetic composition for preventing and treating skin inflammatory diseases contains a volatile perfume ingredient as an active ingredient, contained in a steam distilled extract of Cnidium officinale Makino and Angelica gigas Nakai. The volatile perfume ingredient is eugenol and acetyl eugenol. A health functional food and a cosmetic composition for preventing or treating skin inflammatory diseases contain the extract as an active ingredient. A functional cosmetic composition for antioxidation or anti-aging contains the extract as an active ingredient. [Reference numerals] (AA) Naturally drying medicinal herbs; (BB) Maturing in a traditional pot; (CC) Heating in a heating tank; (DD) Distillation in a distillation facility; (EE) Cooling in a cooling tank; (FF) Storing in a storage tank; (GG) Packaging in a container; (HH) Products

Abstract translation: 目的：提供使用各种药草蒸汽蒸馏提取物治疗炎症的草药雾，以确保优异的抗氧化和抗炎作用。 构成：用于预防和治疗皮肤炎性疾病的化妆品组合物含有作为活性成分的挥发性香料成分，其包含在C ale Mak a a a a a distilled distilled distilled。。。。。 挥发性香料成分是丁子香酚和乙酰丁香酚。 用于预防或治疗皮肤炎性疾病的健康功能食品和化妆品组合物含有提取物作为活性成分。 用于抗氧化或抗衰老的功能性化妆品组合物含有提取物作为活性成分。 [参考号]（AA）天然干草药; （BB）成熟在传统的锅; （CC）在加热罐中加热; （DD）蒸馏设备中的蒸馏; （EE）冷却箱中的冷却; （FF）储存在储罐中; （GG）包装在容器中; （HH）产品

公开(公告)号：KR1020120118379A

公开(公告)日：2012-10-26

申请号：KR1020110035901

申请日：2011-04-18

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원

IPC: C12G3/04 ,  C12G3/02 ,  C12H1/07

CPC classification number: C12G3/04 ,  C12G3/02 ,  C12H1/063

Abstract: PURPOSE: An anti-diabetic functional mulberry extracted liquor and a manufacturing method thereof are provided to reduce blood sugar level, serum insulin level, serum cholesterol and neutral lipid level. CONSTITUTION: A manufacturing method of anti-diabetic functional mulberry extracted liquor comprises the following steps: adjusting the pH of extracted liquid as 5.5 and the sweetness degree as 6 by putting the alive mulberry into potassium metabisulphite containing ionized water; adjusting the pH as 3.6 by adding citric acid and edible sulfuric acid solution; adding sugar(18 Brix) in order to adjust the alcohol concentration as 12% and the sweetness as 24 Brix and agitating thereof and adding yeast; primary fermenting for 2-3 days at 23 deg. Celsius by adding ionized water; compress filtering with non-woven fabric when the specific gravicy becomes 1.02(4.6 Brix) by maturing for 4 days; adding sugar and dissolving thereof and secondary fermenting for 10 days at 18 deg. Celsius; crude filtering after centrifuging at a speed of 8000 rpm for 30 minutes and maturing for 6 months at 18 deg. Celsius; and adjusting the alcohol concentration as 6% and diluting the mulberry wine(alcohol concentration 12%) and acetate agitating and culturing thereof by inoculating acetobacter.

Abstract translation: 目的：提供一种抗糖尿病功能桑叶提取液及其制备方法，以降低血糖水平，血清胰岛素水平，血清胆固醇和中性脂质水平。 构成：抗糖尿病功能桑叶提取液的制备方法包括以下步骤：通过将活性桑树置于含有离子水的偏亚硫酸氢钾中，将提取液的pH值调至5.5，甜度为6; 通过加入柠檬酸和可食用硫酸溶液调节pH为3.6; 加入糖（18白利糖度）以调节酒精浓度为12％，甜度为24白利糖度并搅拌并加入酵母; 主要发酵2-3天，23度。 摄氏度加入电离水; 当比重达到1.02（4.6白利糖度）时通过熟化4天，用无纺布进行压缩过滤; 加入糖并溶解，并在18度二次发酵10天。 摄氏度; 以8000rpm的速度离心30分钟后粗品过滤，并在18℃成熟6个月。 摄氏度; 并调节酒精浓度为6％，稀释桑酒（酒精浓度为12％），乙酸盐通过接种醋杆菌搅拌培养。

公开(公告)号：KR101908772B1

公开(公告)日：2018-10-16

申请号：KR1020160031775

申请日：2016-03-17

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은정 ,  안은영 ,  전영희

IPC: A23L1/30 ,  A61K36/605 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K9/20 ,  A61K9/48 ,  A61K36/605

Abstract: 본발명은상지열수추출물및 상지지표성분인 ORT를함유하는항당뇨조성물에관한것으로 Streptozotocin 유도당뇨쥐에투여하여상백피열수추출물과비교했을때 소장이당류분해효소활성을억제하여혈당을낮추고혈장내 지질개선효과가더 뛰어날뿐만아니라간 조직내로포도당유입을증가시키고글리코겐합성을증가시켜혈당강하효과를확인함으로써상지열수추출물및 상지지표성분인 ORT를함유하는당뇨예방및 치료기능성의약품및 식품조성물로이용할수 있는뛰어난효과가있다.

公开(公告)号：KR101814867B1

公开(公告)日：2018-01-05

申请号：KR1020150024257

申请日：2015-02-17

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  이유진

IPC: C12G3/02 ,  C12J1/00

Abstract: 본발명은발효탱크에서오디즙또는오디에설탕을가하여발효하여제조하는기존의오디와인및 오디식초와달리전통항아리를이용하여오디를가당하여저온숙성시킨후 상엽및 상지추출물을가하여발효하여기능성및 기호성을배가시킨고품질의기능성발효오디와인및 발효오디식초제조방법에관한것으로더욱상세하게는, 뽕나무열매오디를흑설탕과올리고당으로저온숙성하여만든오디청에상엽및 상지물추출액을가하여 24˚Brix로조정한후 알코올및 초산발효하여만든발효오디와인및 발효오디식초의제조방법에관한것이다.

公开(公告)号：KR1020150088414A

公开(公告)日：2015-08-03

申请号：KR1020140008692

申请日：2014-01-24

Applicant: 대구가톨릭대학교산학협력단 ,  서미자 ,  최상원

Inventor： 최상원 ,  남연정 ,  황유경

IPC: A61K36/237 ,  A61K36/9062 ,  A61K36/282 ,  A61P17/00 ,  A61P29/00

Abstract: 한약재추출물을유효성분으로함유하는염증예방또는치료용조성물에관한것으로비발효한약재및 발효한약재의수증기증류추출물을제조하고상기한약재추출물의수율을측정한후 COX-2 저해활성, 5-LOX 저해활성, NO 생성억제능측정하여염증예방의효과를확인하였으며본 발명에따른한약재추출물을유효성분으로함유하는염증예방또는치료용조성물은염증예방에효과가뛰어나고부작용없이안전하게사용할수 있는뛰어난효과가있다.

Abstract translation: 本发明涉及含有药草提取物作为预防或治疗炎症的活性成分的组合物。 证实本发明通过制备未蒸发药草提取物和通过蒸汽蒸馏提取的发酵药草，测定药草提取物的产量，然后测定COX-2抑制活性，具有炎症的预防作用，5-LOX 抑制活性和NO产生抑制活性。 含有药草提取物作为预防或治疗炎症的活性成分的组合物在预防炎症中非常有效，并且可以安全使用而没有副作用。

公开(公告)号：KR1020160101795A

公开(公告)日：2016-08-26

申请号：KR1020150024257

申请日：2015-02-17

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  이유진

IPC: C12G3/02 ,  C12J1/00

CPC classification number: C12G3/02 ,  C12J1/00

Abstract: 본발명은발효탱크에서오디즙또는오디에설탕을가하여발효하여제조하는기존의오디와인및 오디식초와달리전통항아리를이용하여오디를가당하여저온숙성시킨후 상엽및 상지추출물을가하여발효하여기능성및 기호성을배가시킨고품질의기능성발효오디와인및 발효오디식초제조방법에관한것으로더욱상세하게는, 뽕나무열매오디를흑설탕과올리고당으로저온숙성하여만든오디청에상엽및 상지물추출액을가하여 24˚Brix로조정한후 알코올및 초산발효하여만든발효오디와인및 발효오디식초의제조방법에관한것이다.

Abstract translation: 本发明涉及一种制造高品质功能发酵桑果水果酒和发酵桑果醋的方法，其功能性和适口性通过传统罐加入糖进行倍增，进行低温成熟，并加入桑叶和桑树提取物 与传统的桑树果酒和桑果水果醋相比，通过在发酵罐中将桑果汁或桑果添加糖进行发酵而制造发酵。 更具体地说，本发明涉及通过将桑叶和桑叶的水提取物加入桑叶水果糖浆中制造发酵桑果果酒和发酵桑果醋的方法，其是通过在低温下成熟桑树果实制造的 用红糖和寡糖，将糖含量调节至24白利糖度并使用酒精和乙酸进行发酵。

公开(公告)号：KR1020150102833A

公开(公告)日：2015-09-08

申请号：KR1020140024531

申请日：2014-02-28

Applicant: 대구가톨릭대학교산학협력단 ,  영천양잠농업협동조합 ,  최상원

Inventor： 최상원 ,  장연정 ,  이유진 ,  하세비 ,  전영희

IPC: A61K36/605 ,  A61P3/10 ,  B01J19/10

CPC classification number: A61K36/605 ,  B01J19/10

Abstract: 상백피 추출물로부터 분리한 화합물을 유효성분으로 함유하는 당뇨병 예방 및 치료용 조성물에 관한 것으로 뽕나무의 부위별 에탄올 추출물을 제조하고 상기 뽕나무 부위별 추출물의 항당뇨, 항산화, 항노화, 항염증 활성을 측정하여 항당뇨 효능이 높은 상백피 추출물을 크로마토그래피를 이용하여 분리 및 정제한 다음 항당뇨 화합물을 얻은 후 화합물의 α-glucosidase 저해활성을 측정하여 항당뇨 효과를 확인하였으며 본 발명에 따른 상백피 추출물로부터 분리한 화합물은 당뇨병을 예방하고 치료할 수 있으며 부작용에 대한 우려 없이 안전하게 사용할 수 있는 뛰어난 효과가 있다.

Abstract translation: 本发明涉及含有从Mori Radicis Cortex提取物中分离出的化合物作为预防或治疗糖尿病的有效成分的组合物。 纯化该化合物的方法包括：制备桑树的乙醇提取物。 L部分; 测定桑measuring的抗糖尿病，抗氧化，抗衰老和抗炎活性。 L部分提取; 使用色谱仪分离和纯化具有良好抗糖尿病作用的Mori Radicis Cortex提取物后得到抗糖尿病化合物; 并通过测定化合物的α-葡糖苷酶抑制活性来证实抗糖尿病作用。 根据本发明的从Mori Radicis Cortex提取物分离的化合物可以预防和治疗糖尿病，可以安全使用而不考虑副作用并具有优异的效果。