公开(公告)号：KR1020110093211A

公开(公告)日：2011-08-18

申请号：KR1020100013110

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  이상효

IPC: C08F299/04 ,  A61K9/127 ,  A61K31/765

CPC classification number: C08F299/04 ,  A61K31/765 ,  A61K47/30

Abstract: PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.

Abstract translation: 目的：提供生物相容性和温度敏感性的聚乙烯异二聚体/聚酯嵌段共聚物以形成人体内的凝胶，因为通过温度变化能够实现相变，并且能够用作细胞和组织培养的不同形式的底物 。 构成：生物相容性和温度敏感性的聚乙烯亚乙基/聚酯嵌段共聚物包括亲水部分，其包括聚乙二醇和生物相容性聚酯基疏水部分，同时包括己内酯链段和丙交酯链段，其中己内酯片段的摩尔比 丙交酯链段为94：6〜99：1。共聚物在室温下为溶胶相，在30〜50℃下为凝胶相。

公开(公告)号：KR101331136B1

公开(公告)日：2013-11-26

申请号：KR1020110003271

申请日：2011-01-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  김다연 ,  권두연

IPC: A61K9/16 ,  A61K9/06 ,  A61K47/30 ,  A61K47/38

CPC classification number: A61K9/10 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/00 ,  A61K47/34

Abstract: 본 발명은 약물의 초기 방출 제어를 위한 약물전달 시스템에 관한 것으로서, 보다 구체적으로는 생분해성 고분자와 약물을 함유하는 과립; 및 온도감응 하이드로젤을 포함하는 것을 특징으로 하는 약물전달 제형 및 이의 제조방법을 제공하며, 본 발명에 따른 약물전달 제형은 비교적 간단한 단일 공정법에 의하여 제조할 수 있으며, 초반의 약물의 과도한 방출이 없이 일정한 속도로 서서히 방출되어 혈중 약물 농도를 장시간 일정하게 유지시켜 주므로 종래의 주사형 약물전달 제형 및 서방형 과립이 지닌 과도한 초기 방출을 방지하며, 시간 경과에 따른 방출량의 지속성 등 원하는 방출 거동을 쉽게 얻을 수 있다.

公开(公告)号：KR101145175B1

公开(公告)日：2012-05-14

申请号：KR1020100013110

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  이상효

IPC: C08F299/04 ,  A61K9/127 ,  A61K31/765

Abstract: PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.

公开(公告)号：KR1020120081890A

公开(公告)日：2012-07-20

申请号：KR1020110003271

申请日：2011-01-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  김다연 ,  권두연

IPC: A61K9/16 ,  A61K9/06 ,  A61K47/30 ,  A61K47/38

CPC classification number: A61K9/10 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/00 ,  A61K47/34

Abstract: PURPOSE: A drug delivery system for controlling initial drug release is provided to constantly maintain the drug concentration in blood and to prevent excessive drug release at an initial phase. CONSTITUTION: A drug delivery system for controlling initial drug release contains: granules containing biodegradable polymers and drugs; and temperature-sensitive hydrogel. The drug includes drugs for arthiritis, hormone, bone metabolic formulation, immunosuppressant, vitamin, protein or peptide drugs, anticancer agent, analgesic, anti-inflammatory agent, anti-ulcer agent, or diabetes therapeutic agent. The temperature-sensitive hydrogel is poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide)(pluronic), polycarprolactone, polyethylene glycol, algin, alginic acid and alginate, polypeptides and proteins, gelatin and casein, chitin derivatives, and chitosan.

Abstract translation: 目的：提供用于控制初始药物释放的药物递送系统，以不断维持血液中的药物浓度，并防止初始阶段过量的药物释放。 构成：用于控制初始药物释放的药物输送系统包含：含有可生物降解聚合物和药物的颗粒剂; 和温敏水凝胶。 该药物包括用于治疗关节炎，激素，骨代谢制剂，免疫抑制剂，维生素，蛋白质或肽类药物，抗癌剂，止痛剂，抗炎剂，抗溃疡剂或糖尿病治疗剂的药物。 温度敏感的水凝胶是聚（环氧乙烷）聚（环氧丙烷）聚（环氧乙烷）（普朗尼克），聚己内酯，聚乙二醇，藻酸，藻酸和藻酸盐，多肽和蛋白质，明胶和酪蛋白，壳多糖衍生物和壳聚糖 。