公开(公告)号：KR101145175B1

公开(公告)日：2012-05-14

申请号：KR1020100013110

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  이상효

IPC: C08F299/04 ,  A61K9/127 ,  A61K31/765

Abstract: PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.

公开(公告)号：KR1020110093211A

公开(公告)日：2011-08-18

申请号：KR1020100013110

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강윤미 ,  이상효

IPC: C08F299/04 ,  A61K9/127 ,  A61K31/765

CPC classification number: C08F299/04 ,  A61K31/765 ,  A61K47/30

Abstract: PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.

Abstract translation: 目的：提供生物相容性和温度敏感性的聚乙烯异二聚体/聚酯嵌段共聚物以形成人体内的凝胶，因为通过温度变化能够实现相变，并且能够用作细胞和组织培养的不同形式的底物 。 构成：生物相容性和温度敏感性的聚乙烯亚乙基/聚酯嵌段共聚物包括亲水部分，其包括聚乙二醇和生物相容性聚酯基疏水部分，同时包括己内酯链段和丙交酯链段，其中己内酯片段的摩尔比 丙交酯链段为94：6〜99：1。共聚物在室温下为溶胶相，在30〜50℃下为凝胶相。

公开(公告)号：KR101270159B1

公开(公告)日：2013-05-31

申请号：KR1020100013109

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  이상효 ,  손진수 ,  김재일

IPC: A61K9/16 ,  A61K47/30 ,  A61K31/573

Abstract: 본발명은 C~ C의알코올또는분자량이 350 ~ 5,000 g/mole인폴리알킬렌글리콜로구성된친수성부와, 고리형에스터세그먼트와락타이드세그먼트가동시에함유된생분해성폴리에스터계소수성부로구성된중합체에약물이혼입된약물함유고분자미립구및 상기중합체의용융점을제어하여유기용매를적게사용하면서도미립구의수율및 약물의봉입률을증가시킬수 있는상기미립구의제조방법에관한것이다.

公开(公告)号：KR1020110093210A

公开(公告)日：2011-08-18

申请号：KR1020100013109

申请日：2010-02-12

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  이상효 ,  손진수 ,  김재일

IPC: A61K9/16 ,  A61K47/30 ,  A61K31/573

CPC classification number: A61K9/1641 ,  A61K9/1682 ,  A61K31/192 ,  A61K31/216 ,  A61K31/573

Abstract: PURPOSE: A drug-containing polymer microsphere and a method for manufacturing the same are provided to enhance molecular motion and to enhance yield of microsphere. CONSTITUTION: A drug-containing polymer microsphere comprises: a hydrophilic part C2-C10 alcohol or polyalkylene glycol; a biodegradable polyester hydrophobic part containing cyclic ester segment and lactide segment; and a drug. A method for manufacturing the microsphere comprises: a step of polymerizing polyalkylene glycol or C2-C10 alcohol with cyclic ester and lactide at 90-150 °C to prepare a polymer having 1,000-100,000 g/mole of molecular weight; a step of adding drug to the polymer; and a step of dispersing drug in an emulsifier to form a microsphere.

Abstract translation: 目的：提供含药聚合物微球及其制造方法，以增强分子运动并提高微球的产量。 构成：含药聚合物微球包含：亲水部分C 2 -C 10醇或聚亚烷基二醇; 含有环酯段和丙交酯链段的可生物降解的聚酯疏水部分; 和一种药物。 微球的制造方法包括：在90-150℃下使环状酯和丙交酯与聚亚烷基二醇或C 2 -C 10醇进行聚合以制备分子量为1,000-100,000g / mol的聚合物的步骤; 向聚合物中加入药物的步骤; 以及将药物分散在乳化剂中以形成微球的步骤。