公开(公告)号：KR1020140102456A

公开(公告)日：2014-08-22

申请号：KR1020130015768

申请日：2013-02-14

Applicant: 재단법인대구경북과학기술원

Inventor： 이가현 ,  정상원 ,  이세근 ,  이성준 ,  김은주 ,  김현철 ,  최진현 ,  서송이

IPC: A61K47/48 ,  A61K47/38 ,  A61K9/127 ,  A61K31/573

CPC classification number: A61K47/61 ,  A61K9/127 ,  A61K31/573 ,  A61K2121/00

Abstract: The present invention relates to a polymer micelle-medicine complex based on a cellulose-graft-polylactide-based amphiphilic polymer and to a method for producing the same. More specifically, the polymer micelle-medicine complex includes an amphiphilic copolymer having a hydrophilic block including cellulose and a hydrophobic block including polylactide and is formed in a core-shell structure consisting of a hydrophobic core unit and a hydrophilic shell unit. Prednisolone acetate which is a refractory drug is encapsulated in the core unit of the core-shell structure so as to constitute the polymer micelle-medicine complex. The polymer micelle-medicine complex according to the present invention effectively solubilizes the refractory drug and changes the molecular variants of the amphiphilic copolymer so that a micelle having improved stability is produced. Accordingly, the encapsulation efficiency of the refractory drug is maximized and releasing behavior can be easily controlled.

Abstract translation: 本发明涉及基于纤维素接枝聚丙交酯的两亲聚合物的聚合物胶束 - 药物复合物及其制备方法。 更具体地，聚合物胶束 - 药物复合物包括具有包含纤维素的亲水性嵌段和包含聚丙交酯的疏水性嵌段的两亲共聚物，并且形成在由疏水性核心单元和亲水性壳单元组成的核 - 壳结构中。 作为难治性药物的醋酸泼尼松龙被封装在芯 - 壳结构的核心单元中，以构成聚合物胶束 - 药物复合物。 根据本发明的聚合物胶束 - 药物复合物有效地溶解耐火药物并改变两亲性共聚物的分子变体，从而产生具有改善的稳定性的胶束。 因此，耐火药物的包封效率最大化，并且可以容易地控制释放行为。

公开(公告)号：KR1020100027568A

公开(公告)日：2010-03-11

申请号：KR1020080086537

申请日：2008-09-03

Applicant: 재단법인대구경북과학기술원

Inventor： 이성준 ,  이세근 ,  김현철 ,  정상원 ,  최진현 ,  이가현

IPC: C08F263/04 ,  C08J3/12

CPC classification number: C08F263/04 ,  C08F8/12 ,  C08F261/04 ,  C08J3/075 ,  C08J3/12

Abstract: PURPOSE: A fabrication method of monodisperse microball-shaped hydrogel particles is provided to prepare polymer particles using relatively inexpensive water-soluble dispersing stabilizers and a large amount of water as a polymerization solvent through a single process. CONSTITUTION: A fabrication method of monodisperse microball-shaped hydrogel particles comprises the steps of: forming monodispersed polyvinyl acetate microspheres using dispersion polymerization of vinyl acetate monomers; and saponifying the polyvinyl acetate microspheres from a dispersing medium in the same arrangement state so that the polyvinyl acetate microspheres have a dual structure of a polyvinyl acetate/polyvinyl alcohol shell.

Abstract translation: 目的：提供单分散微球形水凝胶颗粒的制造方法，通过单一工艺使用相对便宜的水溶性分散稳定剂和大量的水作为聚合溶剂制备聚合物颗粒。 构成：单分散微球状水凝胶颗粒的制造方法包括以下步骤：使用乙酸乙烯酯单体的分散聚合形成单分散的聚乙酸乙烯酯微球; 并以相同的布置状态从分散介质中皂化聚乙酸乙烯酯微球，使得聚乙酸乙烯酯微球具有聚乙酸乙烯酯/聚乙烯醇壳的双重结构。

公开(公告)号：KR100996610B1

公开(公告)日：2010-11-25

申请号：KR1020080086537

申请日：2008-09-03

Applicant: 재단법인대구경북과학기술원

Inventor： 이성준 ,  이세근 ,  김현철 ,  정상원 ,  최진현 ,  이가현

IPC: C08F263/04 ,  C08J3/12

Abstract: 아세트산비닐 단량체의 분산중합법을 이용해 단분산성 폴리아세트산비닐 미세구를 형성하는 단계, 및 상기 폴리아세트산비닐 미세구를 분산매로부터 분리하지 않고 일 배치 상태에서 비누화함으로써 상기 폴리아세트산비닐 미세구가 폴리아세트산비닐 코어/폴리비닐알코올 쉘의 2중 구조를 갖도록 하는 단계를 포함하는 단분산성 미세구형 수화겔 입자의 제조방법이 제공된다.

公开(公告)号：KR1020100022237A

公开(公告)日：2010-03-02

申请号：KR1020080080813

申请日：2008-08-19

Applicant: 재단법인대구경북과학기술원 ,  주식회사 메타바이오메드

Inventor： 유연춘 ,  박흥수 ,  이세근 ,  이성준 ,  정상원 ,  김현철 ,  이가현 ,  최진현 ,  김한도 ,  김영진

IPC: A61L17/00 ,  A61L31/00 ,  A61L17/10

CPC classification number: A61L17/005 ,  A61L17/10 ,  A61L31/00

Abstract: PURPOSE: A surgical mesh and a method for manufacturing the mesh are provided to obtain an operation convenience by maintaining an initial strength and a rigidity of a conventional polypropylene surgical mesh, to minimize inflammation caused by neophobia after the operation, and obtain excellent biocompatibility by helping a fast growth of a cell. CONSTITUTION: A surgical mesh comprises: a mesh main body; and a coating layer which is coated on the surface of the mesh main body and includes a bioactive substance. The coating layer more includes an adhesive material. The adhesive material is a biodegradable polymer. The bioactive substance is an anti-inflammatory agent, an antioxidant or a mixture of the anti-inflammatory agent and the antioxidant. The anti-inflammatory agent is dexamethasone, prednisolone, aspirin, ibuprofen, indomethacin or naproxen.

Abstract translation: 目的：提供外科手术网及其制造方法，通过维持常规聚丙烯外科手术网的初始强度和刚度，使操作后由于恐惧症引起的炎症减到最小，从而获得操作便利性，并通过帮助获得优异的生物相容性 细胞生长快速。 构成：外科手术网包括：网状主体; 以及涂布在网状物主体的表面上并包含生物活性物质的涂层。 涂层更包括粘合剂材料。 粘合剂材料是可生物降解的聚合物。 生物活性物质是抗炎剂，抗氧化剂或抗炎剂和抗氧化剂的混合物。 抗炎剂是地塞米松，泼尼松龙，阿司匹林，布洛芬，吲哚美辛或萘普生。

公开(公告)号：KR1020100021028A

公开(公告)日：2010-02-24

申请号：KR1020080079723

申请日：2008-08-14

Applicant: 재단법인대구경북과학기술원

Inventor： 이성준 ,  이세근 ,  정상원 ,  김현철 ,  이가현 ,  최진현 ,  김윤미 ,  김한도 ,  김영진

IPC: B82B3/00 ,  B82Y40/00

CPC classification number: C01B33/12 ,  B82Y30/00 ,  B82Y40/00 ,  C01B33/14 ,  C01P2004/64

Abstract: PURPOSE: A method for preparing silica nanoparticles imparting thermal stability and mechanical strength by encapsulating aromatic oil with silica. CONSTITUTION: A method for preparing silica nanoparticles comprises the steps of: (i) forming an emulsion solution by adding surfactant, cosurfactant and aromatic oil to water; and (ii) adding a silica precursor to an emulsion solution to obtain silica nanoparticles. The surfactant is added in the amount of 1-4 weight% based on water. The cosurfactant is added in the amount of 1-10 volume % based on water.

Abstract translation: 目的：制备二氧化硅纳米粒子的方法，通过用二氧化硅包封芳香油赋予热稳定性和机械强度。 构成：制备二氧化硅纳米粒子的方法包括以下步骤：（i）通过向水中加入表面活性剂，辅助表面活性剂和芳香油形成乳液; 和（ii）向乳液溶液中加入二氧化硅前体以获得二氧化硅纳米颗粒。 表面活性剂的添加量为1-4重量％，基于水。 辅助表面活性剂的添加量为1-10体积％，基于水。