公开(公告)号：KR1020040080160A

公开(公告)日：2004-09-18

申请号：KR1020030015037

申请日：2003-03-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김영신 ,  오기봉 ,  강헌중

IPC: C07J71/00 ,  C07J63/00 ,  C07J41/00

Abstract: PURPOSE: Provided is a scalaraminal compound which has excellent antibiotic activity and stability. A process for preparing such compound from a poriferan is also provided. CONSTITUTION: The scalaraminal compound is represented by the formula 1, and is prepared by the process comprising the steps of: lyophilizing a poriferan to completely remove the moisture therefrom; extracting the lyophilized poriferan with methanol and dichloromethane; evaporating the solvents under the reduced pressure; fractionally extracting the obtained residue with methanol and n-hexane; evaporating the resulting methanol layer; fractionally extracting the obtained residue with ethylacetate and water; and purifying the resulting ethylacetate layer using a chromatography.

Abstract translation: 目的：提供具有优异抗生素活性和稳定性的标量化合物。 还提供了一种从苜蓿粉制备这种化合物的方法。 构成：标量化合物由式1表示，并且通过包括以下步骤的方法制备：冻干罂粟籽以从其中完全除去水分; 用甲醇和二氯甲烷萃取冻干的poriferan; 在减压下蒸发溶剂; 用甲醇和正己烷分馏得到的残渣; 蒸发所得甲醇层; 用乙酸乙酯和水分级提取所得残余物; 并使用色谱法纯化所得的乙酸乙酯层。